Jeffrey W Speakman

US Patent:

20080281341, Nov 13, 2008

Filed:

May 12, 2008

Appl. No.:

12/119456

Inventors:

Jason Miller - West Newton PA, US
Jeffrey W. Speakman - Saxonburg PA, US
Ahmed Al-Ghoul - Calgary CA, US
Deepinder Dhaliwal - Pittsburgh PA, US

Assignee:

ENSION, INC. - Pittsburgh PA
UPMC - Pittsburgh PA

International Classification:

A61F 9/007

US Classification:

606166

Abstract:

A method for endothelial keratoplasty donor tissue transport and delivery to a recipient's eye, such as in DLEK, DSEK and DSAEK procedures, comprises the steps of: attaching endothelial keratoplasty donor tissue to a tissue holder, wherein the attachment between the tissue holder and the donor tissue is not on the endothelial layer of the endothelial keratoplasty donor tissue; placing the tissue holder and the attached donor tissue within a surrounding insertion tip; transporting the insertion tip to a position adjacent an access opening in the recipient's eye; inserting the tissue holder with the attached donor tissue through the opening and extending the tissue holder from within the insertion tip to position the donor tissue within the recipient's eye; and separating the attached donor tissue from the tissue holder with the tissue holder within the recipient's eye. An associated apparatus is disclosed.

US Patent:

20130110137, May 2, 2013

Filed:

Oct 1, 2012

Appl. No.:

13/632197

Inventors:

Enrico Nicolo - Jefferson Hill PA, US
Linda Cahalan - Cape Coral FL, US
Greg Johnson - Pittsburgh PA, US
Mark Gartner - Wexford PA, US
Patrick Cahalan - Cape Coral FL, US
Brian J Fill - Pittsburgh PA, US
Ali HUSSAIN - Cape Coral FL, US
Jeffrey W. Speakman - Saxonburg PA, US

Assignee:

Ension, Inc. - Pittsburgh PA

International Classification:

A61L 27/24
A61L 27/22

US Classification:

606151

Abstract:

A variety of polymeric synthetic hernia mesh prosthesis with surface treatment on at least one tissue-facing surface to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm, and ii) a thrombin deactivation of at least 0.2 IU/cm; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment. The synthetic hernia mesh may be formed of monofilament or multifilament polypropylene or polyester, and may be formed as a multi-layer prosthesis with an outer layer formed of a polymeric synthetic hernia mesh with surface treatment to control tissue adhesion coupled to one or more polymeric synthetic hernia meshes without such surface treatments.

US Patent:

20180125620, May 10, 2018

Filed:

Jul 3, 2017

Appl. No.:

15/640873

Inventors:

- Pittsburgh PA, US
Linda Cahalan - Cape Coral FL, US
Greg Johnson - Pittsburgh PA, US
Mark Gartner - Wexford PA, US
Patrick Cahalan - Cape Coral FL, US
Brian J. Fill - Pittsburgh PA, US
Jeffrey W. Speakman - Saxonburg PA, US

International Classification:

A61C 15/04
A61L 31/04
A61B 17/06

Abstract:

A method of treating a tubular medical device with a biomolecule comprises the steps of: a) providing a polyolefin tubular substrate forming a tubular medical device; b) cleaning the tubular polyolefin substrate; c) exposing the tubular polyolefin substrate to a reactive gas containing at least one of acrylic acid and siloxane and to plasma energy to yield a plasma-deposited coating on at least one surface of the tubular polyolefin substrate; and d) attaching a biomolecule to the polyolefin substrate following formation of the plasma-deposited coating on at least one surface of the tubular polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, protein, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.

US Patent:

20140288592, Sep 25, 2014

Filed:

Mar 14, 2014

Appl. No.:

14/214248

Inventors:

Ali HUSSAIN - Cape Coral FL, US
Linda Cahalan - Cape Coral FL, US
Greg Johnson - Pittsburgh PA, US
Mark Gartner - Wexford PA, US
Patrick Cahalan - Cape Coral FL, US
Brian J. Fill - Pittsburgh PA, US
Jeffrey W. Speakman - Saxonburg PA, US

Assignee:

ENSION, INC. - Pittsburgh PA

International Classification:

A61L 31/04
A61C 15/04
A61L 17/00
A61B 17/06
A61B 17/064

US Classification:

606219, 606228, 606230, 427 21, 427 229

Abstract:

A variety of medical devices including staples sutures and dental floss with surface treatment on at least one tissue-facing surface to improve biologic function such as to control tissue adhesion are disclosed including heparin surface treatment which provides heparin present in an amount to yield heparin bioactivity of at least one of i) an ATIII binding of at least 2 pmol/cm, and ii) a thrombin deactivation of at least 0.2 IU/cm; an acrylic surface treatment for coupling thereto of a heparin surface treatment, a collagen surface treatment or both; and an amino-functional polysiloxane surface treatment for coupling thereto of a heparin surface treatment.