Jeffrey K Watkins

US Patent:

20080213281, Sep 4, 2008

Filed:

Dec 4, 2003

Appl. No.:

10/535441

Inventors:

Jeffrey D. Watkins - Encinitas CA, US

Assignee:

Applied Molecular Evolution, Inc. c/o Eli Lilly and Company Patent Division - Indianapolis IN

International Classification:

A61K 39/395
A61K 38/43
C12N 9/00
C07D 471/04
C07H 19/00
A61P 35/00

US Classification:

4241581, 435183, 536 232, 424 941, 546 48

Abstract:

The invention provides a butyrylchinesterase variant, a method of converting a camptothecin derivative to a topoisomerase inhibitor by contacting the camptothecin derivative with a butyrylcholinesterase variant and a method of treating cancer by administering to an individual an effective amount a butyrylcholinesterase variant exhibiting increased capability to convert a camptothecin derivative to a topoisomerase inhibitor compared to butyrylcholinesterase.

US Patent:

55143156, May 7, 1996

Filed:

Jul 29, 1994

Appl. No.:

8/282576

Inventors:

Jeffrey K. Watkins - Rancho Santa Fe CA
Walter R. Cumiskey - Vista CA
Victor B. McCarthy - Vista CA

Assignee:

Watkins Manufacturing Corporation - Vista CA

International Classification:

B29C 5110
B29C 5114

US Classification:

264 80

Abstract:

A process of forming a spa shell by selecting a coextruded polypropylene sheet, selectively heating the sheet, vacuum forming the heated sheet on a deep draw female mold to form a molded spa shell shape, flame treating one surface of the molded shell shape, heating the flame-treated surface, and applying a layer of polyurethane foam to the heated surface.

US Patent:

56154216, Apr 1, 1997

Filed:

Nov 3, 1995

Appl. No.:

8/552884

Inventors:

Jeffrey K. Watkins - Rancho Santa Fe CA
Walter R. Cumiskey - Vista CA
Phillip D. Loizeaux - San Marcos CA

Assignee:

Watkins Manufacturing Corporation - Vista CA

International Classification:

A47K 302

US Classification:

4506

Abstract:

A portable spa including a cover having two rigidly molded, interlocking halves, designed to conform with the contour of the rim of the spa. The rim includes a vertical extension which interfits with an extrusion used to attach an interchangeable decorative vinyl-covered skirt about the side surface of the spa. The spa structure is supported by an integral molded bottom pan, which provides an upper edge or rim against which the lower edge of the skirt is secured.

US Patent:

55641377, Oct 15, 1996

Filed:

Dec 16, 1994

Appl. No.:

8/357414

Inventors:

Jeffrey K. Watkins - Rancho Santa Fe CA
Walter R. Cumiskey - Vista CA
Phillip D. Loizeaux - San Marcos CA

Assignee:

Watkins Manufacturing Corporation - Vista CA

International Classification:

A47K 302
E04H 414

US Classification:

4506

Abstract:

A portable spa including a cover having two rigidly molded, interlocking halves, designed to conform with the contour of the rim of the spa. The rim includes a vertical extension which interfits with an extrusion used to attach an interchangeable decorative vinyl-covered skirt about the side surface of the spa. The spa structure is supported by an integral molded bottom pan, which provides an upper edge or rim against which the lower edge of the skirt is secured.

US Patent:

53983505, Mar 21, 1995

Filed:

Mar 3, 1994

Appl. No.:

8/205609

Inventors:

Jeffrey K. Watkins - Rancho Santa Fe CA
Walter R. Cumiskey - Vista CA

Assignee:

Watkins Manufacturing Corporation - Vista CA

International Classification:

E04H 408

US Classification:

4498

Abstract:

A portable spa including a cover having two semi-circular, rigidly molded, interlocking halves, designed to conform with the contour of the rim of the spa. The cover halves each have an undersurface and outer surface with a plurality of radial support ribs being formed in the undersurface to provide strength and rigidity. Elongated, tapered male and female hinge members are integrally molded as part of the respective cover halves and permit the cover halves to be engaged and disengaged from one another when at an angle with respect to each other, while remaining firmly locked together when each half lies horizontally. The horizontal engagement is further facilitated by resilient fingers which extend out from the male projection at intervals along the cover edge and provide a resiliently biased interlocking mechanism.

US Patent:

56850310, Nov 11, 1997

Filed:

May 2, 1996

Appl. No.:

8/643229

Inventors:

Jeffrey King Watkins - Rancho Santa Fe CA
Walter Richard Cumiskey - Vista CA

Assignee:

Watkins Manufacturing Corporation - Vista CA

International Classification:

E04H 408

US Classification:

4498

Abstract:

A portable spa cover having three rigidly molded, interlocking pieces including two mirror image end pieces and a center piece and designed to conform with the contour of the rim of a spa. Each cover piece has an undersurface and outer surface with a plurality of radial support ribs being formed in the undersurface to provide strength and rigidity. Elongated, tapered male and female hinge members are integrally molded as part of the respective end pieces and center piece and permit the cover pieces to be engaged and disengaged from one another when at an angle with respect to one another, while remaining firmly locked together when the pieces all lie horizontally. The horizontal engagement is further facilitated by resilient fingers which extend out from the male projection at intervals along the cover edge and provide a resiliently biased interlocking mechanism.

US Patent:

54288495, Jul 4, 1995

Filed:

Mar 3, 1994

Appl. No.:

8/205624

Inventors:

Jeffrey K. Watkins - Rancho Santa Fe CA
Walter R. Cumiskey - Vista CA
Phillip D. Loizeaux - San Marcos CA

Assignee:

Watkins Manufacturing Corporation - Vista CA

International Classification:

A47K 302

US Classification:

45411

Abstract:

A portable spa including a cover having two rigidly molded, interlocking halves, designed to conform with the contour of the rim of the spa. The rim includes a vertical extension which interfits with an extrusion used to attach an interchangeable decorative vinyl-covered skirt about the side surface of the spa. The spa structure is supported by an integral molded bottom pan, which provides an upper edge or rim against which the lower edge of the skirt is secured.

US Patent:

D3677087, Mar 5, 1996

Filed:

Mar 3, 1994

Appl. No.:

D/019456

Inventors:

Michael E. Lawing - San Diego CA
Walter R. Cumiskey - Vista CA
Jeffrey K. Watkins - Rancho Santa Fe CA

Assignee:

Watkins Manufacturing Corporation - Vista CA

US Classification:

D24204