Jeffrey S Weber

US Patent:

20060057626, Mar 16, 2006

Filed:

Aug 31, 2005

Appl. No.:

11/218284

Inventors:

Geoffrey Nichol - Short Hills NJ, US
Michael Yellin - Upper Montclair NJ, US
Steven Fischkoff - Short Hills NJ, US
Jeffrey Weber - Los Angeles CA, US

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

The invention provides methods for predicting responsiveness of a subject to therapy with a CTLA-4 blocking agent. The methods involve assaying for at least one CTLA-4 polymorphism in the subject and predicting responsiveness of the subject to therapy with a CTLA-4 blocking agent based on presence or absence of a CTLA-4 polymorphic allele in the subject. The methods can further comprise selecting a treatment regimen with a CTLA-4 blocking agent in a subject based upon presence or absence of a CTLA-4 polymorphic allele in the subject. The methods can further comprise administering a CTLA-4 blocking agent to the subject according to the selected treatment regimen. Kits comprising a CTLA-4 blocking agent and means for assaying one or more CTLA-4 polymorphisms, optionally including a vaccine, are also provided.

US Patent:

20070023436, Feb 1, 2007

Filed:

Aug 1, 2005

Appl. No.:

11/193614

Inventors:

Gladys Sierra-Gomez - Woodbridge NJ, US
Eva Peters - Cedar Grove NJ, US
Thomas Tedeschi - Brewster NY, US
Jeffrey Weber - Lake Zurich IL, US
Stuart Paterson - Fox River Grove IL, US

International Classification:

B65D 17/34

US Classification:

220359200, 220270000

Abstract:

A polygonal shaped container is provided which includes a wrapper surrounding a food product. The shape of the container is defined by either a frame containing a food product or rigid material incorporated with the wrapper. Access to contents in the container is provided by withdrawing a resealable sealing layer sealed to the top or side surface of the container and withdrawing the sealing layer from the container or by pivoting a rigid lid away from the top of the container.

US Patent:

20220246233, Aug 4, 2022

Filed:

Feb 3, 2021

Appl. No.:

17/166483

Inventors:

- Armonk NY, US
Jeffrey Kurt Weber - Brooklyn NY, US
Sugato Bagchi - White Plains NY, US
Wendy Dawn Cornell - Warren NJ, US

International Classification:

G16B 15/30
G06N 3/04
G06N 3/08

Abstract:

A system and method for structure-based, small molecule activity prediction using binding mode prediction information. Binding scores between ligands and target molecules, (e.g. proteins, RNA, DNA, lipids, sugars) are first generated using molecular docking. A first machine learned deep neural network (DNN) model is developed using data representing the molecular ligand-target pair 3D structures and docking features to predict binding modes. Using transfer learning, weights of layers learned in the first machine learned model are used as weights in layers of a second machine learned DNN model used to more accurately improve the performance of activity prediction of the second machine learned model. For a target newly paired ligand-target complex, the method further implements a binding mode selector for selecting one or more particular binding poses for input to the activity prediction model for use in activity mode prediction of an activity of the target paired ligand-protein complex.

US Patent:

20200342953, Oct 29, 2020

Filed:

Apr 29, 2019

Appl. No.:

16/397003

Inventors:

- ARMONK NY, US
Jeffrey Kurt Weber - Brooklyn NY, US
Wendy Dawn Cornell - Warren NJ, US

International Classification:

G16B 15/30
G16B 45/00
G16B 20/30
G16B 40/00
G16B 5/00
G06N 3/08

Abstract:

A computer-implemented method is described. The method includes generating, by a ligand bond graph generator, a first graph based on bond connectivity within a ligand molecule that is specified as input. The method further includes generating, by a ligand-protein graph generator, a second graph based on a contact map of the ligand molecule and a target molecule that is specified as another input. The method further includes receiving docking prediction metrics for the ligand molecule and the target molecule. The method further includes inputting, to a deep neural network, as input features, the first graph, the second graph, and the docking prediction metrics. The method further includes determining, using the deep neural network, a binding mode prediction that characterizes a set of potential interactions between the ligand molecule and the target molecule.

US Patent:

20190329954, Oct 31, 2019

Filed:

Aug 14, 2017

Appl. No.:

16/324095

Inventors:

- East Hanover NJ, US
Ronald H. Exner - Munich, DE
Ying (Lora) Liang - East Hanover NJ, US
Jeffrey T. Weber - Deerfield IL, US
Paul A. Zerfas - East Hanover NJ, US
Evan Michael Ziolkowski - Deerfield IL, US

International Classification:

B65D 77/20

Abstract:

A multi-layer film and a film package made from the film are described herein that provide resealing capabilities by utilizing a tacky layer within the multi-layer film. The multi-layer film can include an outer film portion including the embedded tacky layer and an inner film portion. An opening feature formed in the multi-layer film includes a flap configured to be manipulated by a user to create an opening through the multi-layer film. The inner film portion can include a release layer configured specifically to interact with the tacky layer to provide a desired separation peel force and resealing functionalities. The outer film portion can include an outer film layer disposed on an opposite side of the tacky layer from the release layer that is configured to permanently adhere to the tacky layer.

US Patent:

20170267428, Sep 21, 2017

Filed:

Aug 13, 2015

Appl. No.:

15/503668

Inventors:

- East Hanover NJ, US
Ronald H. Exner - East Hanover NJ, US
Jeffrey T. Weber - East Hanover NJ, US
Leonard S. Scarola - East Hanover NJ, US
Vinay Bhatnagar - East Hanover NJ, US

International Classification:

B65D 75/58
B65B 51/22
B65B 11/48
B65D 85/60
B65D 75/14

Abstract:

A package includes a first pouch and either a second pouch or a cover, where the pouches are configured to contain a product, such as a food product, and attached relative to each other about a hinge. The package includes at least one closure flap. The first and second pouches or first pouch and cover are movable about the hinge from a closed position where access is at least partially blocked by the closure flap when in the closed position and wherein the closure flap is separated to allow greater access when in an open position. Methods of manufacturing such packages are also provided.

US Patent:

20170039345, Feb 9, 2017

Filed:

Jul 12, 2016

Appl. No.:

15/207825

Inventors:

- Boulder CO, US
Krista Meyer - Steamboat Springs CO, US
Julia Grigorieva - Steamboat Springs CO, US
Maxim Tsypin - Steamboat Springs CO, US
Carlos Oliveira - Steamboat Springs CO, US
Arni Steingrimsson - Steamboat Springs CO, US
Heinrich Röder - Steamboat Springs CO, US
Senait Asmellash - Denver CO, US
Kevin Sayers - Denver CO, US
Caroline Maher - Denver CO, US
Jeffrey Weber - New York NY, US

International Classification:

G06F 19/00
G01N 33/68

Abstract:

A method is disclosed of predicting cancer patient response to immune checkpoint inhibitors, e.g., an antibody drug blocking ligand activation of programmed cell death 1 (PD-1) or CTLA4. The method includes obtaining mass spectrometry data from a blood-based sample of the patient, obtaining integrated intensity values in the mass spectrometry data of a multitude of pre-determined mass-spectral features; and operating on the mass spectral data with a programmed computer implementing a classifier. The classifier compares the integrated intensity values with feature values of a training set of class-labeled mass spectral data obtained from a multitude of melanoma patients with a classification algorithm and generates a class label for the sample. A class label “early” or the equivalent predicts the patient is likely to obtain relatively less benefit from the antibody drug and the class label “late” or the equivalent indicates the patient is likely to obtain relatively greater benefit from the antibody drug.

US Patent:

20160016714, Jan 21, 2016

Filed:

Mar 10, 2014

Appl. No.:

14/773016

Inventors:

- East Hanover NJ, US
Rachel LEICHTE - East Hanover NJ, US
Jeffrey Thomas WEBER - East Hanover NJ, US
Evan ZIOLKOWSKI - East Hanover NJ, US

International Classification:

B65D 75/58
B65D 75/30
B65B 61/04
B32B 27/32
B32B 27/08
B32B 27/36
B32B 27/30
B65D 65/40
B65B 61/18

Abstract:

Flexible film packages having an easily opened package feature incorporated therein and method of producing such packages are provided. The package opening feature may be incorporated into a variety of package formats such as flow wrapped packages having a longitudinal seal (including fin seals or lap seals) or packages with side seals (including two-, three-, or four-side seal pouches). In one illustrative approach, the package opening feature is disposed adjacent or at a package seal, such as, for example, an end seal, a top seal, a bottom seal, a side seal, or a longitudinal seal. The flexible film laminate has at least first and second film layers, and at least one of the film layers defining an interior cavity configured to hold food products. In a number of configurations, the flexible film packages may be reclosable or resealable.