Adnan Mjalli - Jamestown NC, US Jeffrey Webster - Jamestown NC, US
Assignee:
TRANSTECH PHARMA, INC. - HIGH POINT NC PFIZER INC. - NEW YORK NY
International Classification:
G01N 33/567 C12M 1/34
US Classification:
435007200, 435287200
Abstract:
Disclosed are methods and systems that use fluorescence polarization to identify compounds that have the ability to bind to, and/or modulate, the activity of the Receptor for Advanced Glycated Endproducts (RAGE). Compounds identified using the methods and systems of the present invention may comprise small organic molecule RAGE antagonists. The small organic molecule RAGE antagonists identified using the methods and systems of the present invention may be used to treat RAGE-mediated diseases, such as, but not limited to, diabetes or Alzheimer's disease.
Rage Fusion Protein Compositions And Methods Of Use
Jeffrey C. Webster - Jamestown NC, US Gregory T. Bleck - Cross Plains WI, US Madan Katragadda - Bedford MA, US Manoj Rajadhyaksha - Colchester CT, US Bernard N. Violand - Wildwood MO, US Jo-Ann Wentland - Pawcatuck CT, US Linda Marie Rothlein - Greensboro NC, US
Disclosed are fusion proteins comprising a RAGE polypeptide, wherein the RAGE polypeptide comprises a fragment of a mammalian wild type RAGE peptide and at least one point mutation in the RAGE polypeptide portion of the fusion protein relative to the wild type RAGE peptide. The point mutation may remove and/or alter a glycosylation site or an enzyme cleavage site. Also disclosed are nucleic acids encoding such proteins as well as methods of using such proteins for treating RAGE-mediated pathologies.
Isbn (Books And Publications)
Critical Advances in Reminisence Work: From Theory to Application
Banner Medical Group Corporate CenterBanner Medical Group Orthopedic Clinic 801 E Williams Ave STE 3301, Fallon, NV 89406 7758677757 (phone), 7754238871 (fax)
Education:
Medical School Wayne State University School of Medicine Graduated: 1986
Procedures:
Arthrocentesis Carpal Tunnel Decompression Hip Replacement Hip/Femur Fractures and Dislocations Knee Arthroscopy Knee Replacement Lower Arm/Elbow/Wrist Fractures and Dislocations Lower Leg/Ankle Fractures and Dislocations Shoulder Arthroscopy Shoulder Surgery
Conditions:
Fractures, Dislocations, Derangement, and Sprains Internal Derangement of Knee Internal Derangement of Knee Cartilage Internal Derangement of Knee Ligaments Intervertebral Disc Degeneration
Languages:
English
Description:
Dr. Webster graduated from the Wayne State University School of Medicine in 1986. He works in Reno, NV and 1 other location and specializes in Orthopaedic Surgery. Dr. Webster is affiliated with Banner Churchill Community Hospital, Northern Nevada Medical Center, Renown Regional Medical Center and Saint Marys Reno Regional Medical Center.
This organization talks about and looks at youth education, diversity and racial reconciliation, and those are the same things Nissan looks at, said Jeffrey Webster, director of human resources for Nissan North America in Canton, near Jackson. He said the gift can be used however the institute see
Date: Apr 12, 2013
Category: U.S.
Source: Google
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