Jennifer Marie Allen

US Patent:

7276516, Oct 2, 2007

Filed:

Dec 13, 2004

Appl. No.:

10/596495

Inventors:

Jennifer Rebecca Allen - Indianapolis IN, US
Albert Kudzovi Amegadzie - Indianapolis IN, US
Kevin Matthew Gardinier - Indianapolis IN, US
George Stuart Gregory - Fishers IN, US
Steven Andrew Hitchcock - Westlake Village CA, US
Paul J. Hoogestraat - Indianapolis IN, US
Daryl Lynn Smith - Fishers IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A01N 43/42
A01N 43/38
A61K 31/44
C07D 471/02
C07D 491/02

US Classification:

514300, 514414, 514418, 514404, 546113, 5462771, 548469, 5483611

Abstract:

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e. g. , multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.

US Patent:

7326731, Feb 5, 2008

Filed:

Sep 9, 2002

Appl. No.:

10/488519

Inventors:

Jennifer Rebecca Allen - Indianapolis IN, US
Stephen Andrew Hitchcock - Carmel IN, US
James Andrew Jamison - Indianapolis IN, US
Bin Liu - Fishers IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31/16
C07C 233/00

US Classification:

514613, 564161

Abstract:

The present invention relates to compounds of Formula I: Formula I which are agonists of the M-1 muscarinic receptor.

US Patent:

7378447, May 27, 2008

Filed:

Mar 12, 2004

Appl. No.:

10/546906

Inventors:

Jennifer Rebecca Allen - Indianapolis IN, US
Stephen Andrew Hitchcock - New Bury Park CA, US
William Wilson Turner - Lawai HI, US
Bin Liu - Fishers IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A01N 37/18
A01N 31/165

US Classification:

514621, 514319, 564147, 564309, 546205

Abstract:

The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

US Patent:

7595339, Sep 29, 2009

Filed:

Aug 17, 2007

Appl. No.:

11/840417

Inventors:

Jennifer Rebecca Allen - Indianapolis IN, US
Albert Kudzovi Amegadzie - Indianapolis IN, US
Kevin Matthew Gardinier - Indianapolis IN, US
George Stuart Gregory - Fishers IN, US
Stephen Andrew Hitchcock - Westlake Village CA, US
Paul J. Hoogestraat - Indianapolis IN, US
Daryl Lynn Smith - Fishers IN, US

Assignee:

Eli Lilly and Company - Indianapolis IN

International Classification:

A61K 31/40

US Classification:

514418

Abstract:

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e. g. , multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.

US Patent:

7854934, Dec 21, 2010

Filed:

Jul 31, 2002

Appl. No.:

10/209618

Inventors:

Samuel J. Danishefsky - Englewood NJ, US
Don M. Coltart - New York NY, US
Stacy J. Keding - New York NY, US
Kaustav Biswas - Thousand Oaks CA, US
Philip O. Livingston - New York NY, US
Jennifer R. Allen - Indianapolis IN, US
Lawrence Williams - Edison NJ, US

Assignee:

Sloan-Kettering Institute For Cancer Research - New York NY

International Classification:

A01N 43/04
A61K 39/385
A61K 31/70
A61K 31/715

US Classification:

4241931, 514 8, 514 23, 514 25, 514 42, 514 53, 514 54, 514 62, 530322, 5361231

Abstract:

The present invention provides novel glycosides and glycoconjugates, glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides novel clustered glycopeptides and methods for the synthesis thereof. In still another aspect, the present invention provides methods for the treatment of cancer, preferably for the prevention of recurrence of cancer, and methods for inducing antibodies in a subject, comprising administering to a subject in need, an effective amount of any of the inventive glycopeptides as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier.

US Patent:

7879335, Feb 1, 2011

Filed:

Aug 18, 2000

Appl. No.:

09/641742

Inventors:

Samuel J. Danishefsky - Englewood NJ, US
Jennifer R. Allen - Indianapolis IN, US
Philip O. Livingston - New York NY, US
Lawrence Williams - New York NY, US

Assignee:

Sloan-Kettering Institute For Cancer Research - New York NY

International Classification:

A01N 43/04
A61K 39/385
A61K 31/70
A61K 31/715

US Classification:

4241931, 514 8, 514 23, 514 25, 514 42, 514 53, 514 54, 514 62, 530322, 5361231

Abstract:

The present invention provides novel n-alkenyl glycosides and glycoconjugates, n-alkyl glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides novel clustered glycopeptides and methods for the synthesis thereof. In still another aspect, the present invention provides methods for the treatment of cancer, preferably for the prevention of recurrence of cancer, and methods for inducing antibodies in a subject, comprising administering to a subject in need, an effective amount of any of the inventive glycoconjugates as disclosed herein.

US Patent:

8623378, Jan 7, 2014

Filed:

Jan 31, 2011

Appl. No.:

13/018249

Inventors:

Samuel J. Danishefsky - Englewood NJ, US
Jennifer R. Allen - Indianapolis IN, US
Philip O. Livingston - New York NY, US
Lawrence Williams - New York NY, US

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

A01N 43/04
A61K 39/385
A61K 31/70
A61K 31/715

US Classification:

4241931, 4241941, 514 193, 514 23, 514 25, 514 42, 514 53, 514 54, 514 62, 530322, 5361231

Abstract:

The present invention provides novel n-alkenyl glycosides and glycoconjugates, n-alkyl glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides novel clustered glycopeptides and methods for the synthesis thereof. In still another aspect, the present invention provides methods for the treatment of cancer, preferably for the prevention of recurrence of cancer, and methods for inducing antibodies in a subject, comprising administering to a subject in need, an effective amount of any of the inventive glycoconjugates as disclosed herein.

US Patent:

20060154922, Jul 13, 2006

Filed:

Mar 12, 2004

Appl. No.:

10/546910

Inventors:

Jennifer Allen - Indianapolis IN, US
Stephen Hitchcock - New Bury Park CA, US
William Turner - Lawai HI, US
Bin Liu - Fishers IN, US

Assignee:

ELILILLY AND COMPANY - Indianapolis IN

International Classification:

A61K 31/54
A61K 31/537
C07D 279/12
C07D 211/06
C07D 265/30
A61K 31/445

US Classification:

514227500, 514237500, 514319000, 544059000, 544159000, 546205000

Abstract:

The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.