Jennifer E Brockman

US Patent:

20070109542, May 17, 2007

Filed:

Aug 2, 2004

Appl. No.:

10/566303

Inventors:

David Tracy - Norwalk CT, US
Jennifer Brockman - Arlington MA, US
Keith Ferrara - Stratford CT, US
Martin Shenker - New York NY, US
Robert Kersten - Granby CT, US
Steven Cohen - South Windsor CT, US
Gary Bodley - Colchester CT, US
Patrick Tuxbury - Wallingford CT, US
Paul Hetherington - Brewster NY, US
Enrico Picozza - Hopkinton MA, US

International Classification:

G01N 21/55

US Classification:

356445000

Abstract:

An optical analysis unit especially suitable for performing grating coupled surface plasmon resonance (SPR) imaging features a pivoting light source capable of scanning through a range of angles of incident light projected onto a stationary target sensor, such as an SPR sensor. The reflected image from the illuminated sensor is detected, e.g., by a CCD camera and the image and angular scan data are processed, for example by a fitting algorithm, to provide real time analysis of reactions taking place on the surface of the sensor.

US Patent:

20090213382, Aug 27, 2009

Filed:

Dec 9, 2008

Appl. No.:

12/330930

Inventors:

David H. Tracy - Norwalk CT, US
Jennifer M. Brockman - Arlington MA, US
Keith S. Ferrara - Stratford CT, US
Martin Shenker - New York NY, US
Robert Kersten - Granby CT, US
Steven E. Cohen - South Windsor CT, US
Gary Bodley - Colchester CT, US
Patrick Tuxbury - Wallingford CT, US
Paul Hetherington - Brewster NY, US
Enrico Picozza - Hopkinton MA, US

Assignee:

GE HEALTHCARE BIO-SCIENCES AB - UPPSALA

International Classification:

G01N 21/55

US Classification:

356445, 13756517

Abstract:

An array surface plasmon resonance (SPR) analysis instrument comprising a reflective SPR sensor array, a light source assembly arranged to project a collimated beam of light onto the reflective SPR sensor array to provide a reflected array image of the sensor array, and to scan the incident angle of the collimated beam of light over an angular range, and a detector assembly oriented to receive the reflected array image of the sensor array over the angular range, the detector assembly comprises a two-dimensional detector sensing element that is tilted with respect to the optical axis of the lens assembly in accordance with the Scheimpflug condition, and a lens assembly for focusing the reflected array image of said SPR sensor array onto said tilted detector sensing element. The lens assembly comprises an objective section which is arranged to produce a virtual image of the tilted reflected array at infinity, followed by an imaging section arranged to transform the virtual image of the tilted reflected array into a real tilted image on the tilted detector sensing element.