Jennifer C Chen

US Patent:

7109307, Sep 19, 2006

Filed:

Nov 20, 2001

Appl. No.:

09/989350

Inventors:

Lih-Ling Lin - Concord MA, US
Jennifer Chen - Chestnut Hill MA, US
Andrea R. Schievella - Winchester MA, US
James Graham - Somerville MA, US

Assignee:

Genetics Institute, LLC - Cambridge MA

International Classification:

C07K 16/28

US Classification:

5303882, 4241391

Abstract:

Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

US Patent:

20060188957, Aug 24, 2006

Filed:

Oct 7, 2005

Appl. No.:

11/245950

Inventors:

Lih-Ling Lin - Concord MA, US
Jennifer Chen - Chestnut Hill MA, US
Andrea Schievella - Winchester MA, US
James Graham - Somerville MA, US

International Classification:

C12P 21/06
C07H 21/04
C07K 14/715
C07K 16/30

US Classification:

435069100, 435320100, 435325000, 530350000, 530388220, 536023500

Abstract:

Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

US Patent:

20090092613, Apr 9, 2009

Filed:

Feb 11, 2008

Appl. No.:

12/069735

Inventors:

Lih-Ling Lin - Concord MA, US
Jennifer Chen - Chestnut Hill MA, US
Andrea R. Schievella - Winchester MA, US
James Graham - Somerville MA, US

International Classification:

A61K 39/395
C12N 15/11
C12N 5/06
C12P 21/04
C07K 14/00
C12Q 1/68
A61K 38/16
C07K 16/18
G01N 33/566

US Classification:

4241391, 536 231, 435325, 435 691, 530350, 514 12, 5303879, 436501, 435 6

Abstract:

Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

US Patent:

20130347136, Dec 26, 2013

Filed:

Apr 11, 2013

Appl. No.:

13/861227

Inventors:

Jennifer Chen - Watertown MA, US
Oliver D. King - Cambridge MA, US

International Classification:

C12Q 1/68
A01K 67/027
C12N 5/077

US Classification:

800 9, 435 613, 435 61, 435325, 435 612, 435 71, 506 9

Abstract:

Compositions and methods for identifying new treatments for Facioscapulohumeral muscular dystrophy (FSHD), and uses thereof.

US Patent:

58495010, Dec 15, 1998

Filed:

Jun 19, 1995

Appl. No.:

8/494440

Inventors:

Lih-Ling Lin - Concord MA
Jennifer Chen - Chestnut Hill MA
Andrea R. Schievella - Winchester MA

Assignee:

Genetics Institute, Inc. - Cambridge MA

International Classification:

G01N 33566
C07K 1471
C07K 14475

US Classification:

435 71

Abstract:

Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

US Patent:

58470999, Dec 8, 1998

Filed:

May 17, 1996

Appl. No.:

8/649341

Inventors:

Lih-Ling Lin - Concord MA
Jennifer Chen - Chestnut Hill MA

Assignee:

Genetics Institute, Inc. - Cambridge MA

International Classification:

C12N 1512
C12N 510
C12N 1563
C07K 1447

US Classification:

536 235

Abstract:

Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

US Patent:

63229722, Nov 27, 2001

Filed:

Nov 2, 1998

Appl. No.:

9/185258

Inventors:

Lih-Ling Lin - Concord MA
Jennifer Chen - Chestnut Hill MA
Andrea R. Schievella - Winchester MA
James Graham - Somerville MA

Assignee:

Genetics Institute, Inc. - Cambridge MA

International Classification:

C12Q 168
G01N 3353

US Classification:

435 6

Abstract:

Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.

US Patent:

58521739, Dec 22, 1998

Filed:

Sep 26, 1995

Appl. No.:

8/533901

Inventors:

Lih-Ling Lin - Concord MA
Jennifer Chen - Chestnut Hill MA
Andrea R. Schievella - Winchester MA
James Graham - Somerville MA

Assignee:

Genetics Institute, Inc. - Cambridge MA

International Classification:

C07K 1747
C07K 1452
C12N 1510

US Classification:

530350

Abstract:

Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.