Jennifer L Foley

US Patent:

8436185, May 7, 2013

Filed:

Jan 8, 2009

Appl. No.:

12/811922

Inventors:

Jennifer R. Foley - Garwood NJ, US
Robert Darrin Wilson - Hoddesdon Herts, GB

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 211/32
A61K 31/445

US Classification:

546199, 514322

Abstract:

The present invention relates to pharmaceutically acceptable salts of an amide substituted indazole which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl) transferase. The compounds of the present invention are useful as mono-therapies in tumors with specific defects in DNA-repair pathways and as enhancers of certain DNA-damaging agents such as anticancer agents and radiotherapy. Further, the compounds of the present invention are useful for reducing cell necrosis (in stroke and myocardial infarction), down regulating inflammation and tissue injury, treating retroviral infections and protecting against the toxicity of chemotherapy.

US Patent:

20090131465, May 21, 2009

Filed:

Oct 27, 2008

Appl. No.:

12/290062

Inventors:

Alex M. Chen - Edison NJ, US
Jennifer R. Foley - Garwood NJ, US
John Limanto - Rahway NJ, US
Robert M. Wenslow - Cream Ridge NJ, US
Karen C. Thompson - Lansdale PA, US
Andrey V. Peresypkin - Cambridge MA, US

International Classification:

A61K 31/438
C07D 401/06
A61P 3/04
A61P 3/10
A61P 15/10

US Classification:

514278, 546 17

Abstract:

The present invention relates to a process for producing crystalline N-[1-((3R)-1′-{[(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidine-3-yl]carbonyl}-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4′-piperidine]-3-yl)-1-methylethyl]acetamide, and novel salts, solvates, hydrates and polymorphs thereof.

US Patent:

20090182002, Jul 16, 2009

Filed:

Dec 17, 2008

Appl. No.:

12/316868

Inventors:

Paolo Avalle - Hertford, GB
Jennifer R. Foley - Garwood NJ, US
Peter Mullens - Welwyn Garden City, GB
Yaling Wang - Westfield NJ, US
Peter Yehl - Cranbury NJ, US

International Classification:

A61K 31/435
C07D 221/16
A61P 35/00

US Classification:

514290, 546 93

Abstract:

This invention relates to salt forms of the compound N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N′-[3-(1-methyl-H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide, an inhibitor of tyrosine kinases, in particular the receptor tyrosine kinase MET, that are useful in the treatment of cellular proliferative diseases, for example cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation. in particular, the invention relates to the sodium salt of N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N′-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfamide.

US Patent:

20100292282, Nov 18, 2010

Filed:

Oct 20, 2008

Appl. No.:

12/681797

Inventors:

Kevin R. Campos - Berkeley Heights NJ, US
Cheng-Yi Chen - Plainsboro NJ, US
Jennifer R. Foley - Garwood NJ, US
Michael Hillier - Libertyville IL, US
Wendy S. Jen - Fanwood NJ, US
Amude M. Kassim - Monmouth Junction NJ, US
Artis Klapars - Edison NJ, US
Andrey V. Peresypkin - Cambridge MA, US
Thorsten Rosner - Berkeley Heights NJ, US
Cecile G. Savarin - Newbury Park CA, US
Matthew Tudge - Chatham NJ, US
Narayan Variankaval - Plainsboro NJ, US
Vicky Vydra - Tinton Falls NJ, US
Dalian Zhao - Fanwood NJ, US

International Classification:

A61K 31/4245
C07D 413/10
C07D 271/113
C07C 255/53
A61P 3/04
A61P 3/10
A61P 25/28

US Classification:

514364, 548144, 558423

Abstract:

The present invention relates to a process for producing crystalline 3-[(1S)-1-(1-{(S)-(4-chlorophenyl)[3-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]methyl}azetidin-3-yl)-2-fluoro-2-methyl-propyl]-5-fluorobenzonitrile, and novel salts, solvates, hydrates and polymorphs thereof.

US Patent:

20210403448, Dec 30, 2021

Filed:

Jun 4, 2021

Appl. No.:

17/339896

Inventors:

- Waltham MA, US
- Rahway NJ, US
Arlene E. McKeown - Rahway NJ, US
Jennifer R. Foley - Rahway NJ, US

International Classification:

C07D 401/10
A61K 9/00
A61K 9/20
A61K 9/48

Abstract:

The present invention relates to compositions comprising the compound niraparib, in particular certain solid forms of niraparib.