Jennifer M Lo

US Patent:

20220213091, Jul 7, 2022

Filed:

Nov 9, 2021

Appl. No.:

17/522628

Inventors:

- Foster City CA, US
Mark J. Bartlett - Castro Valley CA, US
Jayaraman Chandrasekhar - Redmond WA, US
Julian A. Codelli - Seattle WA, US
John H. Conway - Somerville MA, US
Jennifer L. Cosman - Foster City CA, US
Rao V. Kalla - Cupertino CA, US
Zachary A. Kasun - Seattle WA, US
Musong Kim - Bellevue WA, US
Seung H. Lee - Sammamish WA, US
Jennifer R. Lo - Seattle WA, US
Jennifer A. Loyer-Drew - Seattle WA, US
Scott A. Mitchell - Kenmore WA, US
Thao D. Perry - San Jose CA, US
Gary B. Phillips - Issaquah WA, US
Patrick J. Salvo - Burien WA, US
Sundaramoorthi Swaminathan - Burlingame CA, US
Joshua J. Van Veldhuizen - Seattle WA, US
Suet C. Yeung - Redmond WA, US
Jeff Zablocki - Los Altos CA, US

International Classification:

C07D 471/04
C07D 519/00

Abstract:

The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

US Patent:

20230079863, Mar 16, 2023

Filed:

Mar 25, 2022

Appl. No.:

17/704440

Inventors:

- Foster City CA, US
Daniel H. Byun - Foster City CA, US
Christopher T. Clark - Seattle WA, US
Petr Jansa - Foster City CA, US
Joshua A. Kaplan - Foster City CA, US
Zachary A. Kasun - Seattle WA, US
Jennifer R. Lo - Seattle WA, US
Megan E. Neubig - San Diego CA, US
Nathaniel H. Stanley - San Francisco CA, US
Kirk L. Stevens - Bothell WA, US

International Classification:

C07D 409/14
C07D 405/14
C07D 403/14
C07D 401/14
C07D 495/04
C07D 513/04
C07D 493/10
C07D 491/107
C07D 413/14
C07D 403/04
A61K 45/06

Abstract:

Compounds of formula:wherein the variable substituents are defined herein.

US Patent:

20230013585, Jan 19, 2023

Filed:

May 27, 2021

Appl. No.:

17/331900

Inventors:

- Foster City CA, US
Mark J. Bartlett - Castro Valley CA, US
Jayaraman Chandrasekhar - Redmond WA, US
Julian A. Codelli - Seattle WA, US
John H. Conway - Somerville MA, US
Jennifer L. Cosman - Foster City CA, US
Rao V. Kalla - Cupertino CA, US
Musong Kim - Bellevue WA, US
Seung H. Lee - Sammamish WA, US
Jennifer R. Lo - Seattle WA, US
Jennifer A. Loyer-Drew - Seattle WA, US
Scott A. Mitchell - Kenmore WA, US
Thao D. Perry - San Jose CA, US
Gary B. Phillips - Issaquah WA, US
Patrick J. Salvo - Burien WA, US
Joshua J. Van Veldhuizen - Seattle WA, US
Suet C. Yeung - Redmond WA, US
Jeff Zablocki - Los Altos CA, US

International Classification:

A61K 31/4545
A61K 31/444
A61K 31/5386
C07D 471/04
C07D 519/00

Abstract:

The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

US Patent:

20210115037, Apr 22, 2021

Filed:

Oct 30, 2019

Appl. No.:

16/669346

Inventors:

- Foster City CA, US
Mark J. Bartlett - Castro Valley CA, US
Jayaraman Chandrasekhar - Redmond WA, US
Julian A. Codelli - Seattle WA, US
John H. Conway - Seattle WA, US
Jennifer L. Cosman - Foster City CA, US
Rao V. Kalla - Cupertino CA, US
Zachary A. Kasun - Seattle WA, US
Musong Kim - Bellevue WA, US
Seung H. Lee - Sammamish WA, US
Jennifer R. Lo - Seattle WA, US
Jennifer A. Loyer-Drew - Seattle WA, US
Scott A. Mitchell - Kenmore WA, US
Thao D. Perry - San Jose CA, US
Gary B. Phillips - Issaquah WA, US
Patrick J. Salvo - Burien WA, US
Sundaramoorthi Swaminathan - Burlingame CA, US
Joshua J. Van Veldhuizen - Seattle WA, US
Suet C. Yeung - Redmond WA, US
Jeff Zablocki - Los Altos CA, US

International Classification:

C07D 471/04
C07D 519/00

Abstract:

The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

US Patent:

20210060011, Mar 4, 2021

Filed:

Oct 28, 2020

Appl. No.:

17/082595

Inventors:

- San Mateo CA, US
Kevin S. Currie - North Bend WA, US
Jeffrey E. Kropf - Issaquah WA, US
Seung H. Lee - Sammamish WA, US
Jennifer R. Lo - Seattle WA, US
Scott A. Mitchell - Kenmore WA, US
Aaron C. Schmitt - Hamden CT, US
Sundaramoorthi Swaminathan - Burlingame CA, US
Jin-Ming Xiong - Bel Air MD, US
Jianjun Xu - Belevue WA, US
Zhongdong Zhao - Bellevue WA, US

International Classification:

A61K 31/4985
C07D 487/04
A61K 9/00
A61K 31/5377

Abstract:

The present disclosure relates to compounds that are Syk inhibitors or pharmaceutically acceptable salts or co-crystals thereof, and pharmaceutical compositions thereof, and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, a Syk inhibitor is a crystalline monomesylate salt of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo-[1,2-a]pyrazin-8-amine of formula 2:

US Patent:

20200171020, Jun 4, 2020

Filed:

Oct 30, 2019

Appl. No.:

16/668732

Inventors:

- Foster City CA, US
Mark J. Bartlett - Castro Valley CA, US
Jayaraman Chandrasekhar - Redmond WA, US
Julian A. Codelli - Seattle WA, US
John H. Conway - Seattle WA, US
Jennifer L. Cosman - Foster City CA, US
Rao V. Kalla - Cupertino CA, US
Musong Kim - Bellevue WA, US
Seung H. Lee - Sammamish WA, US
Jennifer R. Lo - Seattle WA, US
Jennifer A. Loyer-Drew - Seattle WA, US
Scott A. Mitchell - Kenmore WA, US
Thao D. Perry - San Jose CA, US
Gary B. Phillips - Issaquah WA, US
Patrick J. Salvo - Burien WA, US
Joshua J. Van Veldhuizen - Seattle WA, US
Suet C. Yeung - Redmond WA, US
Jeff Zablocki - Los Altos CA, US

International Classification:

A61K 31/4545
C07D 471/04
A61K 31/444
A61K 31/5386
C07D 519/00

Abstract:

The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

US Patent:

20190388419, Dec 26, 2019

Filed:

May 15, 2019

Appl. No.:

16/413458

Inventors:

- Foster City CA, US
Kevin S. Currie - North Bend WA, US
Jeffrey E. Kropf - Issaquah WA, US
Seung H. Lee - Sammamish WA, US
Jennifer R. Lo - Seattle WA, US
Scott A. Mitchell - Kenmore WA, US
Aaron C. Schmitt - Hamden CT, US
Sundaramoorthi Swaminathan - Burlingame CA, US
Jin-Ming Xiong - Bel Air MD, US
Jianjun Xu - Bellevue WA, US
Zhongdong Zhao - Bellevue WA, US

International Classification:

A61K 31/4985
A61K 31/5377
A61K 9/00
C07D 487/04

Abstract:

The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I:wherein R, R, R, and Rare as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.

US Patent:

20180280387, Oct 4, 2018

Filed:

Feb 28, 2018

Appl. No.:

15/907858

Inventors:

- Foster City CA, US
Astrid Clarke - Bainbridge Island WA, US
Kevin S. Currie - North Bend WA, US
Julie A. Di Paolo - San Francisco CA, US
Jeffrey E. Kropf - Issaquah WA, US
Seung H. Lee - Sammamish WA, US
Jennifer R. Lo - Seattle WA, US
Scott A. Mitchell - Kenmore WA, US
Aaron C. Schmitt - Hamden CT, US
Sundaramoorthi Swaminathan - Burlingame CA, US
Jin-Ming Xiong - Guilford CT, US
Jianjun Xu - Seattle WA, US
Zhongdong Zhao - Bellevue WA, US

International Classification:

A61K 31/4985
A61K 31/5377
A61K 31/519
A61K 31/475

Abstract:

The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I:wherein R, R, R, and Rare as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk. In certain embodiments, also disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, in combination with a vinca-alkaloid, or a pharmaceutically acceptable salt thereof.