Phillip Burwell - Snohomish WA, US Zihong Guo - Bellevue WA, US Jennifer Kristine Matson - Renton WA, US Steven Ross Daly - Sammamish WA, US David B. Shine - Sammamish WA, US Gary Lichttenegger - Woodinville WA, US Jean Bishop - Bothell WA, US Nick Yeo - Great Bookham, GB Hugh Narciso - Santa Barbara CA, US
Assignee:
Light Sciences Oncology, Inc. - Bellevue WA
International Classification:
A61B 19/00
US Classification:
128898, 606 7, 606 15
Abstract:
Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
Phillip Burwell - Snohomish WA, US Zihong Guo - Bellevue WA, US Jennifer Matson - Renton WA, US Steven Daly - Sammamish WA, US David Shine - Sammamish WA, US Gary Lichttenegger - Woodinville WA, US Jean Bishop - Bothell WA, US Nick Yeo - Surrey, GB Hugh Narciso - Santa Barbara CA, US
International Classification:
A61N001/00
US Classification:
600408000
Abstract:
Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
Phillip Burwell - Snohomish WA, US Zihong Guo - Bellevue WA, US Jennifer Matson - Renton WA, US Steven Daly - Sammamish WA, US David Shine - Sammamish WA, US Gary Lichttenegger - Woodinville WA, US Jean Bishop - Bothell WA, US Nick Yeo - Barns Green, GB Hugh Narciso - Santa Barbara CA, US
Assignee:
Light Sciences Oncology, Inc. - Snoqualmie WA
International Classification:
A61N 1/05 A61M 29/02 F21S 2/00
US Classification:
607122000, 362227000, 606194000
Abstract:
Light sources are incorporated into a guidewire for enabling the ability to render light therapy be added to catheters that do not have that capability. In one exemplary embodiment, a solid guidewire includes a conductive core, and light sources are added to compartments formed in a distal end of the guidewire. In another exemplary embodiment, a light source array is included in a distal end of a hollow guidewire. A plurality of openings are formed into the walls of the hollow guidewire surrounding the array, enabling light to pass through the openings. Conductors extend from the array though the hollow center of the guidewire, to a proximal end of the hollow guidewire. The hollow guidewire can be coated with a conductive material, so that the coating on the guidewire serves as a conductor.
Medical Apparatus Employing Flexible Light Structures And Methods For Manufacturing Same
Phillip Burwell - Snohomish WA, US James C. Chen - Clyde Hill WA, US Zihong Guo - Bellevue WA, US Steven R. Daly - Sammamish WA, US David B. Shine - Littleton CO, US Gary Lichttenegger - Woodinville WA, US Jennifer K. Matson - Renton WA, US Jean Bishop - Issaquah WA, US Nick Yeo - Horsham, GB Hugh Narciso - Santa Barbara CA, US
Assignee:
Light Sciences Oncology, Inc. - Bellevue WA
International Classification:
A61B 1/06
US Classification:
600160
Abstract:
A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
Medical Apparatus Employing Flexible Light Structures
Phillip Burwell - Snohomish WA, US James C. Chen - Clyde Hill WA, US Zihong Guo - Bellevue WA, US Steven R. Daly - Sammamish WA, US David B. Shine - Littleton CO, US Jennifer K. Matson - Renton WA, US Jean Bishop - Issaquah WA, US Nick YEO - Horsham, GB Hugh Narciso - Santa Barbara CA, US
Assignee:
Light Sciences Oncology, Inc. - Bellevue WA
International Classification:
A61B 1/06
US Classification:
600178
Abstract:
A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
Method And Apparatus For Treating Benign Prostatic Hyperplasia With Light-Activated Drug Therapy
- STAMFORD CT, US Zihong Guo - Bellevue WA, US Jennifer K. Matson - Renton WA, US Steven Ross Daly - Sammamish WA, US David B. Shine - Sammamish WA, US Gary Lichttenegger - Woodinville WA, US Jean Bishop - Issaquah WA, US Nick Yeo - Great Bookham, GB Hugh Narciso - Santa Barbara CA, US Llew Keltner - Portland OR, US Jay Winship - Bellevue WA, US Erik Hagstrom - Woodinville WA, US Frank Zheng - Kirkland WA, US James C. Chen - Clyde Hill WA, US Joseph M. Hobbs - Issaquah WA, US
Assignee:
PURDUE PHARMACEUTICAL PRODUCTS L.P. - STAMFORD CT
International Classification:
A61N 5/06
Abstract:
A photoreactive agent and a drug therapy device including a support member configured to pass through a urethra having proximal and distal ends and a longitudinal internal lumen. A light generator carried by the support member, potted within the lumen, and positioned within the urethra to deliver light to the prostate. The light generator generates a light band with a peak at a preselected wavelength. A power source external to the support member powers the light generator. The positioning element locates the support member within the urethra. A transparent/translucent, integral window is positioned proximate to the prostate and allows light to pass through. The window extends 360 degrees radially from the support member. The light generator has at least LEDs or LOs having a dimension of approximately 0.3 mm×0.3 mm×0.1 mm (length×width×thickness).