Jennifer Ann Murphy

US Patent:

20130336883, Dec 19, 2013

Filed:

Mar 8, 2012

Appl. No.:

14/002964

Inventors:

Caius G. Radu - Los Angeles CA, US
Johannes Czernin - Pacific Palisades CA, US
Jennifer M. Murphy - Los Angeles CA, US
David A. Nathanson - Los Angeles CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

C07D 417/12
C07D 417/14
G01N 33/50

US Classification:

424 111, 544317, 514274, 435184

Abstract:

The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.

US Patent:

20230114064, Apr 13, 2023

Filed:

Sep 19, 2022

Appl. No.:

17/933234

Inventors:

- Oakland CA, US
- Pasanda CA, US
Jennifer Marie Murphy - Los Angeles CA, US
Robert H. Grubbs - South Pasadena CA, US

International Classification:

C07F 7/12
C07B 59/00
A61K 51/10

Abstract:

The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit.

US Patent:

20200377529, Dec 3, 2020

Filed:

Aug 19, 2020

Appl. No.:

16/997240

Inventors:

- Oakland CA, US
- Pasenda CA, US
Jennifer Marie Murphy - Los Angeles CA, US
Robert H. Grubbs - South Pasadena CA, US

International Classification:

C07F 7/12
C07B 59/00
A61K 51/10

Abstract:

The present disclosure sets forth novel compounds and compositions including heteroaromatic silicon-fluoride-acceptors, which are useful for PET scanning. The present disclosure further includes novel methods of F imaging for PET scanning, the methods comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic silicon-fluoride-acceptors. In certain embodiments the invention is practiced in the form of a kit.

US Patent:

20200106133, Apr 2, 2020

Filed:

Sep 25, 2019

Appl. No.:

16/582540

Inventors:

- Pasadena CA, US
- Oakland CA, US
Christopher M. BATES - Pasadena CA, US
Nebojsa MOMCILOVIC - Pasadena CA, US
Brett M. SAVOIE - Pasadena CA, US
Michael A. WEBB - Pasadena CA, US
Robert H. GRUBBS - Pasadena CA, US
Jennifer M. MURPHY - Pasadena CA, US

Assignee:

CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

H01M 10/0568
H01M 10/0525
H01M 10/0569
H01M 10/054
C07C 209/68

Abstract:

Processes and reaction mixtures including non-aqueous solvent mixtures are presented. Non-aqueous solvent mixtures including fluoride salt and non-aqueous solvent combinations are provided that possess high fluoride ion concentrations useful for a range of applications, including organic synthesis. Further non-aqueous solvent mixtures are provided including a salt possessing a non-fluoride anion and a non-aqueous solvent that, when contacted with aqueous fluoride-containing reagents, extract fluoride ions to form non-aqueous fluoride-ion solutions possessing high fluoride-ion concentrations. The salts include an organic cation that does not possess a carbon in the β-position or does not possess a carbon in the β-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. The combination of these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents.

US Patent:

20180346491, Dec 6, 2018

Filed:

May 24, 2016

Appl. No.:

15/575979

Inventors:

- Oakland CA, US
- Pasadena CA, US
Jennifer Marie MURPHY - Los Angeles CA, US
Robert H GRUBBS - South Pasadena CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
CALIFORNIA INSTITUTE OF THCHNOLOGY - Pasadena CA

International Classification:

C07F 7/12
C07B 59/00

Abstract:

The present invention includes novel compounds and compositions including heteroaromatic Silicon-Fluoride-Acceptors, which are useful for PET scanning. The present invention further includes a novel method of 18F imaging for PET scanning, the method comprising the preparation of conjugates and bioconjugates of biological ligands of interest with heteroaromatic SiFAs. In one embodiment the invention is practiced in the form of a kit.

US Patent:

20170204090, Jul 20, 2017

Filed:

Jan 31, 2017

Appl. No.:

15/421258

Inventors:

- OAKLAND CA, US
- URBANA IL, US
RAYMOND M. GIPSON - LOS ANGELES CA, US
JUE WANG - LOS ANGELES CA, US
ARNON LAVIE - CHICAGO IL, US
JENNIFER M. MURPHY - LOS ANGELES CA, US
DAVID A. NATHANSON - LOS ANGELES CA, US
MICHAEL E. JUNG - LOS ANGELES CA, US

International Classification:

C07D 417/14
C07B 59/00
C07D 417/12

Abstract:

Provided herein are compounds that bind to dCK and methods for treating cancer.

US Patent:

20170057908, Mar 2, 2017

Filed:

Aug 4, 2016

Appl. No.:

15/229026

Inventors:

- Pasadena CA, US
- Oakland CA, US
Christopher M. BATES - Monrovia CA, US
Nebojsa MOMCILOVIC - Vienna VA, US
Brett M. SAVOIE - Pasadena CA, US
Michael A. WEBB - Pasadena CA, US
Robert H. GRUBBS - South Pasadena CA, US
Jennifer M. MURPHY - Los Angeles CA, US

International Classification:

C07C 209/68

Abstract:

Processes and reaction mixtures including non-aqueous solvent mixtures are presented. Non-aqueous solvent mixtures including fluoride salt and non-aqueous solvent combinations are provided that possess high fluoride ion concentrations useful for a range of applications, including organic synthesis. Further non-aqueous solvent mixtures are provided including a salt possessing a non-fluoride anion and a non-aqueous solvent that, when contacted with aqueous fluoride-containing reagents, extract fluoride ions to form non-aqueous fluoride-ion solutions possessing high fluoride-ion concentrations. The salts include an organic cation that does not possess a carbon in the β-position or does not possess a carbon in the β-position having a bound hydrogen. This salt structure facilitates its ability to be made anhydrous without decomposition. Example anhydrous fluoride salts include (2,2-dimethylpropyl)trimethylammonium fluoride and bis(2,2-dimethylpropyl)dimethylammonium fluoride. The combination of these fluoride salts with at least one fluorine-containing non-aqueous solvent (e.g., bis(2,2,2-trifluoroethyl)ether; (BTFE)) promotes solubility of the salt within the non-aqueous solvents.