Jennifer S Richardson

US Patent:

6485921, Nov 26, 2002

Filed:

Dec 24, 1998

Appl. No.:

09/220399

Inventors:

Andrew W. Shyjan - Nahant MA
Jennifer Richardson - Boston MA
John Vassiliadis - Marlborough MA

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

G01N 33574

US Classification:

435 723, 435 4, 435 72, 435 721, 435 681, 530300

Abstract:

The invention concerns ubiquitin-conjugating enzyme-like protein (UBCLP) nucleic acid molecules, polypeptides, antibodies, and modulators. The invention also concerns screening assays which can be used to identify compounds useful for the treatment of prostate cancer and diagnostic assays which can be used to detect prostate cancer, and prognostic assays which can be used to monitor prostate cancer therapy.

US Patent:

20020123081, Sep 5, 2002

Filed:

Sep 28, 2001

Appl. No.:

09/967305

Inventors:

Jennifer Richardson - Boston MA, US
John Monahan - Walpole MA, US

International Classification:

G01N033/574
C12Q001/68

US Classification:

435/007230, 435/006000

Abstract:

Methods for identifying patients having or at risk of developing prostate cancer (including hormone refractory or androgen independent prostate cancer) and patients having or at risk of developing a cancer arising from metastasis if a prostate cancer to another tissue, e.g., liver and lymph node, by measuring the expression or activity of alpha-methylacyl-CoA racemase are described. The invention also provides: methods of screening for compounds that can be used to treat prostate cancer (including hormone refractory or androgen independent prostate cancer) or metastases of prostate cancer by screening for compounds that modulate the expression or activity of the alpha-methylacyl-CoA racemase polypeptides or nucleic acids; a process for modulating (i.e., reducing) alpha-methylacyl-CoA racemase polypeptide or nucleic acid expression or activity, e.g., using the screened compounds; and methods for selecting patients for therapy with a compound that reduces the activity or expression of alpha-methylacyl-CoA racemase as well as methods for determining whether such a therapy should be continued in a patient.

US Patent:

20090148834, Jun 11, 2009

Filed:

Jun 20, 2007

Appl. No.:

11/820705

Inventors:

Jennifer Richardson - Boston MA, US
John Monahan - Walpole MA, US

International Classification:

C12Q 1/68
C12Q 1/00
C12Q 1/02
C07H 21/00
C07K 14/00

US Classification:

435 6, 435 4, 435 29, 536 231, 530350

Abstract:

Methods for identifying patients having or at risk of developing prostate cancer (including hormone refractory or androgen independent prostate cancer) and patients having or at risk of developing a cancer arising from metastasis if a prostate cancer to another tissue, e.g., liver and lymph node, by measuring the expression or activity of alpha-methylacyl-CoA racemase are described. The invention also provides: methods of screening for compounds that can be used to treat prostate cancer (including hormone refractory or androgen independent prostate cancer) or metastases of prostate cancer by screening for compounds that modulate the expression or activity of the alpha-methylacyl-CoA racemase polypeptides or nucleic acids; a process for modulating (i.e., reducing) alpha-methylacyl-CoA racemase polypeptide or nucleic acid expression or activity, e.g., using the screened compounds; and methods for selecting patients for therapy with a compound that reduces the activity or expression of alpha-methylacyl-CoA racemase as well as methods for determining whether such a therapy should be continued in a patient.

US Patent:

61435201, Nov 7, 2000

Filed:

Apr 15, 1998

Appl. No.:

9/060659

Inventors:

Wayne A. Marasco - Wellesley MA
Jennifer Richardson - Boston MA
Maria Cristina Parolin - Padua, IT
Joseph G. Sodroski - Medford MA

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

C12P 2106
C12N 1564
C12N 1500
A61K 3912
A61K 3921

US Classification:

435 691

Abstract:

The present invention is related to vectors and methods for increasing the expression of a desired gene product. Preferably this invention is used with genes expressing proteins that are not well tolerated by mammalian cells or where high levels of expression are necessary. In certain preferred embodiments it can be used as part of a multi-tiered expression system and with methods of intracellularly targeting a molecule.

US Patent:

60049405, Dec 21, 1999

Filed:

Dec 6, 1994

Appl. No.:

8/350215

Inventors:

Wayne A. Marasco - Wellesley MA
Jennifer Richardson - Cambridge MA

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

A61K 4800

US Classification:

514 44

Abstract:

The present invention relates to a method by which one can target an undesired target molecule or target antigen, preferably an endogenous protein. The method comprises the intracellular expression of an antibody capable of binding to the target. A DNA sequence is delivered to a cell, the DNA sequence contains a sufficient number of nucleotides coding for the portion of an antibody capable of binding to the target operably linked to a promoter that will permit expression of the antibody in the cell(s) of interest. The antibody is then expressed intracellularly and binds to the target, thereby disrupting the target from its normal actions.

US Patent:

20150309223, Oct 29, 2015

Filed:

Apr 23, 2014

Appl. No.:

14/259543

Inventors:

- Charlotte NC, US
Jennifer S. Richardson - Westford MA, US

Assignee:

GOODRICH CORPORATION - Charlotte NC

International Classification:

G02B 5/20
H04N 5/225
H04N 5/357
H04N 5/335

Abstract:

An optical sensor includes an array of pixels configured to convert photons into electrons for forming an image or to measure spectral content without forming an image. A filter assembly is operatively associated with the array of pixels for passing predetermined bandwidths of photons to the array of pixels. A mask is operatively associated with the array of pixels and the filter assembly. The mask includes a plurality of apertures each for limiting photons passing through the filter assembly to a respective pixel in the array of pixels.

US Patent:

20150100716, Apr 9, 2015

Filed:

Aug 15, 2014

Appl. No.:

14/461086

Inventors:

Jennifer S. Richardson - Westford MA, US
Scott W. Ramsey - Northbridge MA, US

International Classification:

G06F 13/40
G06F 13/16

US Classification:

710308, 710313

Abstract:

A system for managing internal-computer system communications including a processor, an SPI controller, an interconnector, and an SPI cluster containing multiple SPI interfaces, with the SPI interfaces being connected to one or more devices in the computer system or environment. The SPI cluster includes SPI interfaces that can convert communications to/from a plurality of device's formats to serialized digital formats suitable for ingest and actuation for the SPI controllers. The interconnector may use a differentially, optically, galvanometrically, inductively coupled driven wire and to enable communications between the SPI cluster constituents and the SPI controller. The SPI controller manages communications to the SPI interfaces that act as coordinated intermediates for device control and communications, thus insulating the computer system's processor from the increased workload of managing all internal system communications.