Jennifer S Rota

US Patent:

55784488, Nov 26, 1996

Filed:

Jul 25, 1994

Appl. No.:

8/279700

Inventors:

Jennifer S. Rota - Decatur GA
William J. Bellini - Lilburn GA

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C07H 2104
C12P 1934
C12Q 168
C12Q 170

US Classification:

435 5

Abstract:

The present invention provides nucleic acids encoding consensus hemagglutinin and consensus fusion polypeptides which contain at least one amino acid substitution relative to the Moraten vaccine strain that is found in at least one strain of wild-type measles virus. Nucleic acid reagents useful for detecting and differentiating wild-type measles strains by polymerase chain reaction and a method utilizing the same are provided. Recombinant vectors comprising nucleic acids encoding the consensus hemagglutinin and/or the consensus fusion polypeptides are also provided.