Jennifer J Roth

US Patent:

8133471, Mar 13, 2012

Filed:

Dec 21, 2009

Appl. No.:

12/643926

Inventors:

Peter C. Brooks - Scarborough ME, US
Jennifer Roth - North Babylon NY, US
Abebe Akalu - Forest Hills NY, US

Assignee:

New York University - New York NY

International Classification:

A61K 51/00

US Classification:

424 111, 424 91, 424 93

Abstract:

The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially greater affinity than to the native triple helical form of collagen type-IV. Methods utilizing such antagonists for therapeutic treatment of tumor growth, tumor metastasis or of restenosis also are described, as are methods to use such antagonists as diagnostic markers of angiogenesis in normal or diseased tissues both in vivo and ex vivo. The invention further describes methods for treating tumors using said antagonists in combination with radiation therapy and therapies comprising the antagonists and radiation treatment.

US Patent:

20120237504, Sep 20, 2012

Filed:

Oct 14, 2010

Appl. No.:

13/395373

Inventors:

Peter C. Brooks - Scarborough ME, US
Jennifer M. Roth - Scarborough ME, US

Assignee:

MAINE MEDICAL CENTER - Scarborough ME

International Classification:

A61K 39/395
A61K 31/7088
A61P 29/00
A61P 17/16
A61P 17/06
A61P 9/10
A61P 1/00
A61P 27/02
A61P 19/02
A61P 9/00
A61P 17/00
A61K 38/08
A61K 38/10
A61P 11/00
A61P 1/16
A61P 13/12
A61P 25/00
A61K 38/02

US Classification:

4241331, 514 172, 4241721, 514 44 R, 4241521, 4241391, 514 19, 514 151, 514 154

Abstract:

The present invention features compositions featuring agents that bind to denatured collagen and methods of using such agents to treat or prevent fibrosis or inflammation in a subject.