Dietrich A. STEPHAN - San Francisco CA, US Eric M. Reiman - Scottsdale AZ, US Jennifer Webster - Phoenix AZ, US Christopher B. Heward - Mesa AZ, US Pamela Heward - Mesa AZ, US Andreas Papassotiropoulos - Zurich, CH
Assignee:
Translational Genomics Research Institute - Phoenix AZ Kronos Science Laboratory - Phoenix AZ
The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.
Methods Of Diagnosing Alzheimer's Disease And Markers Identified By Set Association
Dietrich A. Stephan - Phoenix AZ, US Eric M. Reiman - Scottsdale AZ, US Jennifer Webster - Phoenix AZ, US Christopher B. Heward - Mesa AZ, US Pamela Heward - Mesa AR, US Andreas Papassotiropoulos - Zurich, CH
Assignee:
TRANSLATIONAL GENOMICS RESEARCH INSTITUTE - Phoenix AZ KRONOS SCIENCE LABORATORY - Phoenix AZ
International Classification:
C12Q 1/68 C07H 21/04 A01K 67/027 G01N 33/00
US Classification:
800 3, 435 6, 536 2431, 800 13
Abstract:
The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.
Nov 2010 to 2000 Co-Occurring SpecialistSears Roebuck
Sep 2003 to 2000 Fine Jewelry ConsultantASAP Glendale, AZ Apr 2009 to Aug 2010 Practicum Training AssociateArgosy University Phoenix, AZ Jul 2008 to Jul 2010 Student Services AssociateMcDonald's Food Restaurant Glendale, AZ Sep 1999 to Jul 2001 Assistant Crew ManagerVocational Consultants Phoenix, AZ May 1998 to May 1998 Supervising Assistant
Education:
Argosy University Sep 2006 to Jul 2010 Masters of Arts in Clinical PsychologyWestern International University Sep 2002 to Jun 2006 Bachelors of Arts in Behavioral SciencesGlendale Community College Aug 2000 to May 2002 psychology and business
Teacher FBC Weekday EducationOxford, MS Nov 2010 to Aug 2011Customer Service RepresentativeOlive Branch, MS Oct 2009 to 2010Kohl's Collierville, TN Oct 2007 to 2008 Freight AssociateSmokey Bones Southaven, MS Feb 2007 to May 2007 ServerFazolis Southaven, MS May 2006 to Feb 2007 AssociateFazolis Olive Branch, MS May 2006 to Sep 2006 Cashier
Kodiak Island Medical Associates 1818 E Rezanof Dr, Kodiak, AK 99615 9074866065 (phone), 9074862248 (fax)
Education:
Medical School St. George's University School of Medicine, St. George's, Greneda Graduated: 1998
Languages:
English Spanish Tagalog
Description:
Dr. Webster graduated from the St. George's University School of Medicine, St. George's, Greneda in 1998. She works in Kodiak, AK and specializes in Family Medicine. Dr. Webster is affiliated with Providence Kodiak Island Medical Center.
BayCare Medical GroupBayCare Medical Group Suncoast Medical Clinic Dermatology 620 10 St N STE 3A, Saint Petersburg, FL 33705 7278247102 (phone), 7278247125 (fax)
Languages:
English Spanish
Description:
Ms. Webster works in Saint Petersburg, FL and specializes in Dermatology. Ms. Webster is affiliated with St Anthonys Hospital.
Massachusetts General Hospital Thoracic Surgery 55 Fruit St STE 1570, Boston, MA 02114 6177240969 (phone), 6177267667 (fax)
Languages:
English Italian Spanish
Description:
Ms. Webster works in Boston, MA and specializes in General Practice. Ms. Webster is affiliated with Massachusetts General Hospital and Newton-Wellesley Hospital.
Taylor School Swan River Palestinian Territory, Occupie 1981-1988, Swan River Junior High School Swan River Palestinian Territory, Occupie 1988-1991, Swan River Collegiate High School Swan River Palestinian Territory, Occupie 1990-1994
Community:
R Thompson, Dan Kopecky, Melody Kowalko, Margaret Curtis, Sonya Ukrainec, Mary Bryan