Jennifer Lyn Webster

US Patent:

20090260092, Oct 15, 2009

Filed:

Jun 18, 2009

Appl. No.:

12/487608

Inventors:

Dietrich A. STEPHAN - San Francisco CA, US
Eric M. Reiman - Scottsdale AZ, US
Jennifer Webster - Phoenix AZ, US
Christopher B. Heward - Mesa AZ, US
Pamela Heward - Mesa AZ, US
Andreas Papassotiropoulos - Zurich, CH

Assignee:

Translational Genomics Research Institute - Phoenix AZ
Kronos Science Laboratory - Phoenix AZ

International Classification:

A01K 67/027
C12Q 1/68
G01N 33/53
C40B 30/04
C07H 21/04

US Classification:

800 3, 435 6, 435 71, 506 9, 536 2431, 800 12

Abstract:

The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.

US Patent:

20090249498, Oct 1, 2009

Filed:

Apr 21, 2008

Appl. No.:

12/148728

Inventors:

Dietrich A. Stephan - Phoenix AZ, US
Eric M. Reiman - Scottsdale AZ, US
Jennifer Webster - Phoenix AZ, US
Christopher B. Heward - Mesa AZ, US
Pamela Heward - Mesa AR, US
Andreas Papassotiropoulos - Zurich, CH

Assignee:

TRANSLATIONAL GENOMICS RESEARCH INSTITUTE - Phoenix AZ
KRONOS SCIENCE LABORATORY - Phoenix AZ

International Classification:

C12Q 1/68
C07H 21/04
A01K 67/027
G01N 33/00

US Classification:

800 3, 435 6, 536 2431, 800 13

Abstract:

The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD.