Jens J Billgren

US Patent:

20120294797, Nov 22, 2012

Filed:

May 21, 2012

Appl. No.:

13/476465

Inventors:

Brian Robert Kovacevich - Snohomish WA, US
Leon F. Garcia-Martinez - Woodinville WA, US
Katie Olson - Kenmore WA, US
Benjamin H. Dutzar - Seattle WA, US
Jens J. Billgren - Seattle WA, US
John A. Latham - Seattle WA, US
Danielle M. Mitchell - Seattle WA, US
Patricia Dianne Mcneill - Federal Way WA, US
Nicole M. Janson - Edmonds WA, US
Maria-Cristina Loomis - Bothell WA, US

International Classification:

C07K 16/18
C12N 15/63
C12N 1/19
A61K 39/395
A61K 49/00
A61K 51/00
C12Q 1/68
C12N 5/10
C12N 1/15
C12N 1/21
A61P 25/06
A61P 3/00
A61P 35/00
A61P 25/00
A61P 29/00
A61P 19/08
A61P 1/16
A61P 13/12
A61P 13/00
A61P 3/10
A61P 37/00
A61P 9/00
A61P 19/02
A61P 11/00
A61P 11/06
A61P 25/36
A61P 15/00
A61P 17/00
A61P 17/06
A61P 25/08
A61P 25/28
A61P 17/04
A61P 1/00
A61P 37/08
A61P 31/00
C12N 15/13

US Classification:

424 111, 5303891, 5303873, 5303913, 5303917, 536 2353, 4353201, 43525423, 4241721, 424 91, 424 96, 5303911, 4241331, 435 61, 435332, 43525411, 43525233, 4241581

Abstract:

The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V, Vand CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.

US Patent:

20130302399, Nov 14, 2013

Filed:

Mar 12, 2013

Appl. No.:

13/795674

Inventors:

Andrew Lawrence Feldhaus - Lynnwood WA, US
Leon F. Garcia-Martinez - Woodinville WA, US
Benjamin H. Dutzar - Seattle WA, US
Ethan Wayne Ojala - Snohomish WA, US
Brian Robert Kovacevich - Snohomish WA, US
Katie Olson - Kenmore WA, US
Pei Fan - Bothell WA, US
Jens Billgren - Seattle WA, US
Erica Ann Stewart - Shoreline WA, US
Corinne C. Akatsuka - Hilo HI, US
Patricia Dianne McNeill - Federal Way WA, US
Danielle Marie Mitchell - Seattle WA, US
Dan Scott Allison - Lake Forrest Park WA, US
John A. Latham - Seattle WA, US

International Classification:

C07K 16/40
A61K 45/06
A61K 39/395

US Classification:

424450, 5303898, 5303917, 435188, 5303872, 4241581, 536 2353, 4353201, 435338, 4352523, 43525411, 4352542, 43525423, 43525422, 43525421, 4352543, 4352547, 4352546, 4352544, 435 696, 435 74, 5303913

Abstract:

The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V, Vand CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.

US Patent:

20130336975, Dec 19, 2013

Filed:

Mar 15, 2013

Appl. No.:

13/833338

Inventors:

Benjamin H. Dutzar - Seattle WA, US
Brian R. Kovacevich - Snohomish WA, US
Patricia Dianne McNeill - Federal Way WA, US
Danielle M. Mitchell - Seattle WA, US
Ethan W. Ojala - Snohomish WA, US
Pei Fan - Bothell WA, US
Jens Billgren - Seattle WA, US
Erica A. Stewart - Shoreline WA, US
Corinne C. Akatsuka - Hilo HI, US
Betty Yu-Ching Chang - Cupertino CA, US
John A. Latham - Seattle WA, US
Leon F. Garcia-Martinez - Woodinville WA, US

International Classification:

C07K 16/22

US Classification:

4241351, 5303892, 5303873, 5303913, 5303917, 536 2353, 4353201, 435335, 4352542, 4352523, 43525411, 435419, 4241581, 435 71, 435328

Abstract:

The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V, Vand CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.

US Patent:

20120148490, Jun 14, 2012

Filed:

Dec 1, 2011

Appl. No.:

13/309295

Inventors:

Benjamin H. Dutzar - Seattle WA, US
Brian R. Kovacevich - Snohomish WA, US
Patricia Dianne NcNeill - Federal Way WA, US
Danielle M. Mitchell - Seattle WA, US
Ethan W. Ojala - Snohomish WA, US
Pei Fan - Bothell WA, US
Jens Billgren - Seattle WA, US
Erica A. Stewart - Shoreline WA, US
Corinne C. Akatsuka - Hilo HI, US
Betty Yu-Ching Chang - Cupertino CA, US
John A. Latham - Seattle WA, US
Leon F. Garcia-Martinez - Woodinville WA, US

International Classification:

A61K 39/395
C12N 15/13
A61K 49/00
A61K 51/10
A61P 29/00
A61P 25/00
A61P 19/10
A61P 35/00
A61P 1/16
A61P 25/06
A61P 31/04
A61P 21/00
C12N 15/63
C12N 5/10
C12N 1/21
C12N 1/15
C12N 1/19
C12N 9/96
C12P 21/02
A61P 37/08
C07K 16/22

US Classification:

424 149, 5303892, 5303873, 5303913, 536 2353, 4241581, 424 91, 5303917, 5303911, 4353201, 435335, 4352523, 435419, 43525411, 4352542, 43525423, 424 96, 435188, 530367, 435 696, 800 6

Abstract:

The present invention is directed to antibodies and fragments thereof having binding specificity for NGF. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V, Vand CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-NGF antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-NGF antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-NGF antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with NGF.

US Patent:

20220306734, Sep 29, 2022

Filed:

Jul 22, 2020

Appl. No.:

17/629213

Inventors:

- Valby, DK
Leon F. GARCIA-MARTINEZ - Woodinville WA, US
Benjamin H. DUTZAR - Seattle WA, US
Daniel S. ALLISON - Forest Park WA, US
Jens BILLGREN - Seattle WA, US
Michelle SCALLEY-KIM - Seattle WA, US
Ethan Wayne OJALA - Snohomish WA, US
Jenny MULLIGAN - Lake Forest Park WA, US
Pei FAN - Bothell WA, US
Maria-Cristina LOOMIS - Bothell WA, US
Jeffrey T.L. SMITH - Dublin, IE
John A. LATHAM - Seattle WA, US
Vanessa Lisbeth RUBIN - Seattle WA, US

International Classification:

C07K 16/28
A61P 1/04
A61P 13/10
A61P 25/06

Abstract:

This invention generally pertains to antibodies and antigen-binding antibody Fragments, preferably humanized, chimeric, and human antibodies and antigen-binding antibody fragments. compositions containing such antibodies and antigen-binding antibody fragments or cells, e.g., immune cells such as T, Treg, or NK cells which express same, wherein such antibodies and antigen-binding antibody Fragments specifically bind to mGluR5. The invention also relates to therapeutic and diagnostic uses for the antibodies, antigen-binding antibody fragments, and compositions thereof.

US Patent:

20220289836, Sep 15, 2022

Filed:

Dec 16, 2021

Appl. No.:

17/553280

Inventors:

- VALBY, DK
Leon F. GARCIA-MARTINEZ - Woodinville WA, US
Benjamin H. DUTZAR - Seattle WA, US
Daniel S. ALLISON - Lake Forest Park WA, US
Katherine Lee HENDRIX - Renton WA, US
Ethan W. OJALA - Snohomish WA, US
Pei FAN - Bothell WA, US
Jeffrey T.L. SMITH - Bellevue WA, US
John A. LATHAM - Seattle WA, US
Charlie KARASEK - Seattle WA, US
Jenny MULLIGAN - Lake Forest Park WA, US
Michelle SCALLEY-KIM - Seattle WA, US
Erica STEWART - Seattle WA, US
Vanessa Lisbeth RUBIN - Seattle WA, US
Jens J. BILLGREN - Bothell WA, US

International Classification:

C07K 16/26
A61K 39/395

Abstract:

The present invention is directed to antagonistic antibodies and antigen binding fragments thereof having binding specificity for PACAP. These antibodies inhibit, block or neutralize at least one biological effect associated with PACAP, e.g., vasodilation. In exemplary embodiments these antibodies and antigen binding fragments thereof may comprise specific V, V, and CDR polypeptides described herein. In some embodiments these antibodies and antigen binding fragments thereof bind to and/or compete for binding to specific epitope(s) on human PACAP. The invention is further directed to using these antagonistic anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, mast cell degranulation, and/or neuronal activation, are therapeutically beneficial, e.g., headache and migraine indications.

US Patent:

20230125604, Apr 27, 2023

Filed:

Apr 19, 2022

Appl. No.:

17/723674

Inventors:

- Valby, DK
Leon Garcia-Martinez - Woodinville WA, US
Benjamin H. Dutzar - Seattle WA, US
Daniel S. Allison - Lake Forest Park WA, US
Katherine Lee Hendrix - Bothell WA, US
Ethan W. Ojala - Snohomish WA, US
Pei Fan - Bothell WA, US
Jeffrey T.L. Smith - Dublin, IE
John A. Latham - Seattle WA, US
Charlie Karasek - Seattle WA, US
Jenny Mulligan - Lake Forest Park WA, US
Michelle Scalley-Kim - Seattle WA, US
Erica Stewart - Seattle WA, US
Vanessa Lisbeth Rubin - Seattle WA, US
Jens J. Billgren - Seattle WA, US

International Classification:

C07K 14/705
C12N 15/09
C12N 15/63
A61K 39/395
C07K 16/28
A61K 38/17
A61K 38/22
C07K 14/47
C07K 14/72
C07K 16/18
C12N 5/07
C07K 16/26
C07K 16/42
G01N 33/68

Abstract:

The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the V, V, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and/or neuronal activation, would be therapeutically beneficial.

US Patent:

20210380676, Dec 9, 2021

Filed:

Mar 15, 2021

Appl. No.:

17/201424

Inventors:

- Valby, DK
- Iowa City IA, US
Levi P. SOWERS - Iowa City IA, US
Andrew F. RUSSO - Iowa City IA, US
Maria-Cristina LOOMIS - Bothell WA, US
Leon F. GARCIA-MARTINEZ - Woodinville WA, US
Benjamin H. DUTZAR - Seattle WA, US
Daniel S. ALLISON - Lake Forest Park WA, US
Katherine Lee HENDRIX - Renton WA, US
Ethan W. OJALA - Snohomish WA, US
Pei FAN - Bothell WA, US
Jeffrey T.L. SMITH - Bellevue WA, US
John A. LATHAM - Seattle WA, US
Charlie KARASEK - Seattle WA, US
Jenny MULLIGAN - Lake Forest Park WA, US
Michelle SCALLEY-KIM - Seattle WA, US
Erica STEWART - Seattle WA, US
Vanessa Lisbeth RUBIN - Seattle WA, US
Jens J. BILLGREN - Bothell WA, US

International Classification:

C07K 16/26
A61K 39/395

Abstract:

This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.