Jerald S Bradshaw

US Patent:

49433750, Jul 24, 1990

Filed:

Sep 6, 1988

Appl. No.:

7/240689

Inventors:

Jerald S. Bradshaw - Provo UT
Reed M. Izatt - Provo UT
Ronald L. Bruening - Provo UT
James J. Christensen - late of Provo UT

Assignee:

Brigham Young University - Provo UT

International Classification:

B01D 1500

US Classification:

210674

Abstract:

The invention has composition of matter and process aspects. The composition of matter aspect relates to the compounds selected from the class consisting of: ##STR1## in which Silica is sand or silica gel. The process aspect involves the use of any of these compounds packed in a column through which a solution of the multiple ions is flowed to complex with the compound and separate a desired selected ion from a multiple ion solution, breaking the complex by flowing a receiving liquid through the column to free the desired ion and recovering the freed desired ion from the receiving liquid.

US Patent:

60714166, Jun 6, 2000

Filed:

Dec 14, 1998

Appl. No.:

9/202731

Inventors:

Ronald L. Bruening - American Fork UT
Krzysztof E. Krakowiak - Provo UT
Reed M. Izatt - Provo UT
Jerald S. Bradshaw - Provo UT

Assignee:

IBC Advanced Technologies, Inc. - American Fork UT

International Classification:

C02F 142

US Classification:

210670

Abstract:

A method and composition for the concentration and removal of desired metal ions from a source solution by contacting the solution with an N-cyclic aromatic hydrocarbon-containing ligand covalently bonded to a solid support through a hydrophilic spacer of the formula SS--A--X--(L). sub. n where SS is a solid support, A is covalent linkage mechanism, X is a hydrophilic spacer grouping, L is an N-cyclic aromatic containing ligand group and n is an integer of 1 to 6. X or L combined will not contain more than two amine nitrogen atoms. There will preferably be at least four N-cyclic groups present of which pyridine, pyrimidine, pyraxine, imidazole, quinoline, isoquinoline, naphthyridine, pyridopyridine, phenanthroline are representative. The desired ions in the source solution are bound to the ligands and are subsequently separated by contacting the ligand containing compound with a smaller volume of a receiving solution that removes the bound ions for recovery in concentrated form in the smaller volume of the receiving solution.

US Patent:

52684423, Dec 7, 1993

Filed:

May 4, 1992

Appl. No.:

7/878157

Inventors:

Jerald S. Bradshaw - Provo UT
Bryant E. Rossiter - Provo UT
Bryon J. Tarbet - Provo UT
Deborah F. Johnson - Provo UT
Milton L. Lee - Pleasant Grove UT
Karin E. Markides - Upsala, SE

Assignee:

Brigham Young University - Provo UT

International Classification:

C08G 7704

US Classification:

528 25

Abstract:

Chiral copolymers containing chiral molecular grooves or cavities and oligosiloxane spacers are disclosed. The chiral portion of the copolymer is an enantiomerically enriched organic grouping, having physical properties attributed to uniform and stereochemically possible molecular grooves or cavities, which is chemically and thermally stable to gas, liquid or supercritical s fluid chromatographic conditions and is configured such that one enantiomer of an enantiomeric mixture will be better able to preferentially enter such groove or cavity and interact more strongly than other enantiomers in said mixture. The chiral grouping will contain one Or more combinations of organic moieties selected from the group consisting of methylene, phenylene, naphthylene, biphenylene, binaphthylene, a cyclodextrin and cycloalkylydene and substituted derivatives thereof and also includes non-metal atoms and functional groups which act as linking agents for the organic chiral cavity-containing moieties which are selected from the group consisting of ethers, thioethers, amines, carbonyls, amides, esters, sulfoxides, sulfonates, thioamides, thioesters, ureas, thioureas, carbamates, thiocarbamates, phosphines and phosphine oxides. The use of such polymers as chiral stationary phases in analytical and preparative gas, supercritical fluid and liquid chromatographic separations, and particularly for analysis of enantiomeric and other stereoisomeric mixtures of various substances is shown.

US Patent:

49753797, Dec 4, 1990

Filed:

Apr 10, 1989

Appl. No.:

7/335591

Inventors:

Jerald S. Bradshaw - Provo UT
Reed M. Izatt - Provo UT
Ronald L. Bruening - Provo UT
Virginia B. Christensen - Provo UT
Robert Alldredge - Westminster CO

Assignee:

Brigham Young University - Provo UT

International Classification:

G01N 3000
C02F 162

US Classification:

436 77

Abstract:

The invention is a process of selectively and quantitatively removing and concentrating at least one selected ion prosent in low concentration with other ions in higher concentration in a multiple ion solution. The method comprises bringing a complexing agent for the selected ion(s) into contact with a different determined quantity of said multiple ion solution to remove and concentrate the selected ion(s) from the multiple ion solution; removing the multiple ion solution, from which the complexing agent has been removed, the selected ions from the complexing agent having the selected ion(s) complexed therewith, bringing the complexing agent complexed with selected ion(s) into contact with a determined quantity of receiving liquid to break the complex and remove the selected and concentrated ion(s) from the complexing agent therein, and determining the concentration of selected ion(s) in said receiving liquid from which the concentration of selected ion(s) in the multiple ion solution can be calculated. The metal ions in low concentration are often heavy metal ions, such as lead ions, and the process finds particularly advantageous utility in the determination of lead content in ppb in drinking water. The preferred apparatus for carrying out the process is a column packed with silica gel or silica-bonded macrocycle as the complexing agent which is preferably carried out using as the complexing agent a macrocyclic compound having at least four --A--CH. sub. 2 --CH. sub.

US Patent:

50394193, Aug 13, 1991

Filed:

Sep 24, 1990

Appl. No.:

7/587254

Inventors:

Jerald S. Bradshaw - Provo UT
Reed M. Izatt - Provo UT
Bryon J. Tarbet - Provo UT
Krzysztof Krakowiak - Provo UT
Jan F. Biernat - Provo UT
Ronald L. Bruening - Provo UT

Assignee:

Brigham Young University - Provo UT

International Classification:

B01D 3900
B01D 1508

US Classification:

2105021

Abstract:

The invention has compositions of matter and process aspects. The compositions of matter aspect relate to two classes of new organic compounds, viz. , A. intermediates which are sulfur-containing hydrocarbons covalently bonded to trialkoxysilane and B. that class of intermediates covalently bonded to an inorganic matrix, e. g. , silica, silica gel, glass, glass fibers, alumina, nickel oxide, zirconia, and titania. The process aspect comprises two processes, viz. , (1) a process for making the two new classes of compounds A and B, and (2) the process of removing and concentrating certain ions, such as noble metal ions and other transition metal ions, from solution thereof admixed with other ions which may be present in much higher concentrations by forming a complex of the desired ion(s) with a compound of class B, e. g. , by flowing the solution through a chromatography column packed with the compound, breaking the complex, e. g. , by flowing a receiving liquid through the column in much smaller amount than the amount of solution passed through it to remove and concentrate the desired ion(s) in solution in the receiving liquid and recovering the desired ion(s) from the receiving liquid.

US Patent:

49591533, Sep 25, 1990

Filed:

Jul 13, 1988

Appl. No.:

7/218156

Inventors:

Jerald S. Bradshaw - Provo UT
Byron J. Tarbet - Provo UT
Krzysztof E. Krakowiak - Provo UT
Jan F. Biernat - Provo UT
Ronald L. Bruening - Provo UT
Reed M. Izatt - Provo UT

Assignee:

Brigham Young University - Provo UT

International Classification:

B01D 1500

US Classification:

210670

Abstract:

The invention has compositions of matter and process aspects. The compositions of matter aspect relate to two classes of new organic compounds, viz. , A. intermediates which are sulfur-containing hydrocarbons covalently bonded to trialkoxysilane and B. that class of intermediates covalently bonded to silica, e. g. , sand and silica gel. The process aspect comprises two processes, viz. , (1) A process for making the two new classes of compounds A and B, and (2) the process of removing and concentrating certain ions, such as noble metal ions and other transition metal ions, from solutions thereof admixed with other ions which may be present in much higher concentrations by forming a complex of the desired ion(s) with a compound of class B, e. g. , by flowing the solution through a chromatography column packed with the compound, breaking the complex, e. g. , by flowing a receiving liquid through the column in much smaller amount than the amount of solution passed through it to remove and concentrate the desired ion(s) in solution in the receiving liquid and recovering the desired ion(s) from the receiving liquid.

US Patent:

54038987, Apr 4, 1995

Filed:

Dec 7, 1993

Appl. No.:

8/163870

Inventors:

Jerald S. Bradshaw - Provo UT
Milton L. Lee - Pleasant Grove UT
Bryant E. Rossiter - Provo UT

Assignee:

Brigham Young University - Provo UT

International Classification:

C08F28300

US Classification:

525474

Abstract:

Cyclodextrin containing polymeric siloxanes wherein the cyclodextrin is connected to the polymeric siloxane by a single linking member connected to the 2, 3 or 6-position of the cyclodextrin are disclosed. These polymers are chemically and thermally stable to gas, supercritical fluid chromatographic conditions. The single arm attachment provides cyclodextrin containing polysiloxane polymers having synthesis reproducibility from batch to batch resulting in consistent chromatographic performance of the resulting chiral phases. The use of such polymers as chiral stationary phases in analytical and preparative gas, supercritical fluid and liquid chromatographic separations, and particularly for analysis of enantiomeric and other stereoisomeric mixtures of various substances is shown.

US Patent:

51751100, Dec 29, 1992

Filed:

Nov 30, 1990

Appl. No.:

7/621524

Inventors:

Jerald S. Bradshaw - Provo UT
Reed M. Izatt - Provo UT
Ronald L. Bruening - Provo UT
James J. Christensen - late of Provo UT
Robert Alldredge - Westminster CO

Assignee:

Brigham Young University - Provo UT

International Classification:

G01N 3000
C02F 102

US Classification:

436 77

Abstract:

A method of selectively and quantitatively removing and concentrating at least one selected ion from a multiple ion solution in which other ions are present is disclosed. The method comprises (a) bringing a complexing agent for the selected ion(s) into contact with the multiple ion solution to remove and concentrate selected ion(s) from the multiple ion solution, wherein the complexing agent is selected from the group of macrocyclic compounds having at least four --A--CH. sub. 2 --CH. sub. 2 -- groups in which A is selected from O, O--CH. sub. 2, S, S--CH. sub. 2, N--R and N--R--CH. sub. 2 in which R is selected from H, lower alkyl and benzyl, with the macrocyclic compounds further having a hydrocarbon side chain having an end group ##STR1## in which X is selected from the group consisting of lower alkyl, benzyl, phenyl, halogen, O--CH. sub. 3, O--C. sub. 2 H. sub. 5 and O--M, wherein M is selected from the group consisting of sand, silica gel, glass, glass fibers, alumina, zirconia, titania and nickel oxide; (b) removing the multiple ion solution from which the complexing agent has removed the selected ion(s) from the complexing agent having the selected ion(s) complexed therewith; (c) bringing the complexing agent complexed with selected ion(s) into contact with a receiving liquid to break the complex and remove the selected and concentrated ion(s) from the complexing agent; and (d) determining the concentration of selected ion(s) in the receiving liquid from which the concentration of selected ion(s) in the multiple ion solution can be calculated.