Jerrold M Liesch from 6312 Young Buck Cir, Columbia, MD 21045, age 75, Phone: 4107995850

Novel Antifungal Substances And Process For Their Production
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US Patent:

50285378, Jul 2, 1991
Filed:

Jun 6, 1988
Appl. No.:

7/202612
Inventors:

Richard W. Burg - Murray Hill NJ
Otto D. Hensens - Red Bank NJ
Jerrold M. Liesch - Princeton Junction NJ
Sebastian Hernandez - Madrid, ES
Lucille J. Cole - Stanley KS
Assignee:

Merck & Co. Inc. - Rahway NJ
International Classification:

C12P 1300
C12P 762
C12P 726
C12N 120
US Classification:

435128
Abstract:

There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compounds' structures are present based upon analytical studies. The compounds have antifungal activity.

Antifungal Agent
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US Patent:

49526049, Aug 28, 1990
Filed:

May 3, 1989
Appl. No.:

7/346768
Inventors:

Otto D. Hensens - Red Bank NJ
Jerrold M. Liesch - Princeton Junction NJ
James A. Milligan - Plainsboro NJ
Sagrario M. Del Val - Madrid, ES
Robert E. Schwartz - Westfield NJ
Carol Wichmann - Westfield NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

A61K 3135
C07D30910
US Classification:

514459
Abstract:

Pyranyl ester compounds isolated from the fermentation of the species Penicillium are described. The compounds are useful as antifungal agents.

Oxytocin And Vasopressin Antagonists
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US Patent:

50950037, Mar 10, 1992
Filed:

Oct 23, 1990
Appl. No.:

7/604394
Inventors:

Michael A. Goetz - Fanwood NJ
Lawrence R. Koupal - Colonia NJ
Cheryl D. Schwartz - Westfield NJ
Jerrold M. Liesch - Princeton Junction NJ
Otto D. Hensens - Red Bank NJ
Paul S. Anderson - Lansdale PA
Roger Freidinger - Hatfield PA
Douglas J. Pettibone - Chalfont PA
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

A61K 3734
C07K 716
US Classification:

514 9
Abstract:

Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis, ATTCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.

Antifungal Agent Obtained From Hormonema
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US Patent:

57564728, May 26, 1998
Filed:

Jan 27, 1997
Appl. No.:

8/789349
Inventors:

Jerrold M. Liesch - Princeton Junction NJ
Maria S. Meinz - Fair Haven NJ
Janet C. Onishi - Westfield NJ
Sandra A. Morris - Westfield NJ
Robert E. Schwartz - Scotch Plains NJ
Gerald F. Bills - Clark NJ
Robert A. Giacobbe - Lavallette NJ
Wendy S. Horn - Westfield NJ
Deborah L. Zink - Manalapan NJ
Angeles Cabello - Madrid, ES
Maria T. Diez - Madrid, ES
Isabella Martin - Madrid, ES
Fernando Pelaez - Madrid, ES
Francisca Vicente - Madrid, ES
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

A61K 3170
C12N 114
C07D31500
US Classification:

514 27
Abstract:

There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.

Antifungal Agents
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US Patent:

57705879, Jun 23, 1998
Filed:

Oct 21, 1996
Appl. No.:

8/734701
Inventors:

Angela Basilio - Madrid, ES
Fernando Pelaez - Madrid, ES
Maria Teresa Diez - Madrid, ES
Francisca Vicente - Madrid, ES
Sandra A. Morris - Westfield NJ
James E. Curotto - Morgan NJ
Gerald F. Bills - Clark NJ
Sarah J. Dreikorn - Scotch Plains NJ
Otto D. Hensens - Red Bank NJ
Jerrold M. Liesch - Princeton Junction NJ
Rosalind G. Jenkins - Somerset NJ
John R. Thompson - Scotch Plains NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

A61K 3156
US Classification:

514120
Abstract:

There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.

Antifungal Fermentation Product And Derivatives And Compositions Thereof
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US Patent:

48472840, Jul 11, 1989
Filed:

Mar 23, 1988
Appl. No.:

7/172164
Inventors:

Robert E. Schwartz - Westfield NJ
Janet C. Onishi - Mountainside NJ
Richard L. Monaghan - Somerset NJ
Jerrold M. Liesch - Princeton Junction NJ
Otto D. Hensens - Red Bank NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C07D20724
A61K 3140
US Classification:

514424
Abstract:

A novel pyrrolidinol isolated from the fermentation of Aspergillus ochraceus and certain derivatives thereof are described. The compounds are broad spectrum antifungal agents.

Antifungal Agent Produced By Arthrinium Arundinis Atcc 74359
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US Patent:

57121095, Jan 27, 1998
Filed:

Jan 27, 1997
Appl. No.:

8/789348
Inventors:

Jerrold M. Liesch - Princeton Junction NJ
Maria S. Meinz - Fair Haven NJ
Janet C. Onishi - Westfield NJ
Robert E. Schwartz - Scotch Plains NJ
Gerald F. Bills - Clark NJ
Robert A. Giacobbe - Lavallette NJ
Deborah L. Zink - Manalapan NJ
Angeles Cabello - Madrid, ES
Maria T. Diez - Madrid, ES
Isabella Martin - Madrid, ES
Fernando Pelaez - Madrid, ES
Francisca Vicente - Madrid, ES
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C12P 3300
C12N 114
A61K 3156
C07J 900
US Classification:

435 52
Abstract:

There is disclosed a compound having the formula ##STR1## which is produced by the fungus, Arthrinium arundinis ATCC 74359, and exhibits antifungal activity.

Antifungal Agent And Method
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US Patent:

48682080, Sep 19, 1989
Filed:

Jul 15, 1988
Appl. No.:

7/219943
Inventors:

David F. Sesin - Westfield NJ
Jerrold M. Liesch - Princeton Junction NJ
Assignee:

Merck & Co., Inc. - Rahway NJ
International Classification:

C07D30302
US Classification:

514475
Abstract:

Novel semi-synthetic antifungal compounds which may be produced from 10-[(3-chloro-4-methoxyphenyl)methyl]-6- methyl-3-(2-methylpropyl)-16-[1-(3-phenyloxiranyl)ethyl]-1,4-dioxa- 8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone isolated from the fermentation of a cyanobacterium (Nostoc sp. ) are described.

Jerrold M Liesch