Jessica F Greene

US Patent:

20070117782, May 24, 2007

Filed:

Dec 1, 2006

Appl. No.:

11/566171

Inventors:

Bruce Hammock - Davis CA, US
Jiang Zheng - Seattle WA, US
Christophe Morisseau - Davis CA, US
Kazuhiko Motoba - Kawachinagano, JP
Mehran Moghaddam - San Diego CA, US
Babak Borhan - East Lansing MI, US
David Grant - Storrs CT, US
Jessica Greene - Oakland CA, US
Marlene Sisemore - Davis CA, US
James Sanborn - Sacramento CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 31/66
A61K 31/17

US Classification:

514114000, 514580000, 514588000

Abstract:

The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R-Ris hydrogen, Ris hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, Ris hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, Rand Ris each independently C-Csubstituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.

US Patent:

59554967, Sep 21, 1999

Filed:

Aug 12, 1997

Appl. No.:

8/909523

Inventors:

Bruce D. Hammock - Davis CA
Mehran F. Moghaddam - Wilmington DE
Jeffrey M. Cheek - Sacramento CA
Babak Borhan - New York NY
James Fergusson - Davis CA
David F. Grant - Little Rock AK
Jessica F. Greene - Davis CA
Kazuhiko Matoba - Osaka, JP
Jiang Zheng - Davis CA
Marlene F. Sisemore - Davis CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 3134
C07D30712

US Classification:

514473

Abstract:

The present invention provides novel biologically active tetrahydrofuran diols of arachidonic acid.

US Patent:

61746959, Jan 16, 2001

Filed:

May 14, 1999

Appl. No.:

9/312207

Inventors:

Bruce D. Hammock - Davis CA
Mehran F. Moghaddam - Wilmington DE
Jeffrey M. Cheek - Sacramento CA
Babak Borhan - New York NY
James Fergusson - Davis CA
David F. Grant - Little Rock AR
Jessica F. Greene - Davis CA
Kazuhiko Matoba - Osaka, JP
Jiang Zheng - Davis CA
Marlene F. Sisemore - Davis CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12Q 134

US Classification:

435 18

Abstract:

The present invention provides methods of treating inflammatory diseases mediated by poly-unsaturated lipid metabolites by inhibiting epoxide hydrolase, methods for assaying or screening the epoxide hydrolase inhibitors for inhibitory specificity and for toxicity, and novel biologically active tetrahydrofuran diols of arachidonic acid, including antibodies thereto.