Jessica Li

US Patent:

7785793, Aug 31, 2010

Filed:

Oct 9, 2008

Appl. No.:

12/287480

Inventors:

Weiwei Li - Lindenhurst NY, US
Jessica Li - Lindenhurst NY, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

This invention is related to a method and assay kit for rapidly quantifying global DNA methylation through immobilizing DNA by simple dry-capture on the plastic carrier followed by immunodetection of 5-methylcytosine structure that is the marker of DNA methylation.

US Patent:

8206935, Jun 26, 2012

Filed:

Jul 1, 2010

Appl. No.:

12/803666

Inventors:

Weiwei Li - Lindenhurst NY, US
Jessica Li - Lindenhurst NY, US

International Classification:

G01N 33/53

US Classification:

435 71, 435 4

Abstract:

This invention is related to a method for rapidly quantifying hydroxymethylated DNA by binding DNA to a plastic carrier followed by immunodetection of 5-hydroxymethylcytosine or a hydroxymethylcytosine structure that is marker of DNA hydroxymethylation.

US Patent:

20070042384, Feb 22, 2007

Filed:

Dec 1, 2004

Appl. No.:

11/001283

Inventors:

Weiwei Li - New York NY, US
Jessica Li - New York NY, US

International Classification:

C12Q 1/68
C07H 21/04

US Classification:

435006000, 536025400

Abstract:

This invention is related a method for rapidly isolating and modifying DNA from plasma/serum and body fluids. This invention provides a procedure and composition to obtain a high yield of modified DNA for methylation-specific PCR assay by coupling DNA isolation and modification courses.

US Patent:

20070141582, Jun 21, 2007

Filed:

Dec 15, 2005

Appl. No.:

11/303815

Inventors:

Weiwei Li - New York NY, US
Jessica Li - New York NY, US

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435006000, 435091200

Abstract:

This invention is related to a method for the detection of early or pre-cancer using DNA isolated from blood and body fluids. This invention provides an improved methylation-based PCR assay, a panel of methylated-based cancer-related gene markers for the detection of general cancer and a panel of demethylation-based tissue- or cell-specific gene markers for discriminating different type of cancer detected from blood samples. This method couples a sequential cancer-related gene marker detection and tissue or cell-specific gene marker assay and is particularly useful as a simultaneous screening test for following type of cancer: lung, breast, ovarian, colon, stomach, prostatic, pancreatic and liver cancer.

US Patent:

20070141583, Jun 21, 2007

Filed:

Dec 20, 2005

Appl. No.:

11/313014

Inventors:

Weiwei Li - New York NY, US
Jessica M. Li - New York NY, US

International Classification:

C12Q 1/68
C12N 1/08

US Classification:

435 6, 435270

Abstract:

This invention is related to a method for rapidly identifying regions of the genome to which specific proteins bind, or identifying specific proteins bound to a region of the genome in vivo.

US Patent:

20080193931, Aug 14, 2008

Filed:

Feb 8, 2007

Appl. No.:

11/703983

Inventors:

Weiwei Li - Brooklyn NY, US
Jessica Li - Brooklyn NY, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

This invention is related to a method and assay kit for rapidly quantifying global DNA methylation through immobilizing DNA by simple dry-capture on the plastic carrier followed by immunodetection of 5-methylcytosine structure that is the marker of DNA methylation.

US Patent:

20090181373, Jul 16, 2009

Filed:

Jan 10, 2008

Appl. No.:

12/008292

Inventors:

Weiwei Li - Lindenhurst NY, US
Jessica Li - Lindenhurst NY, US

International Classification:

C12Q 1/68

US Classification:

435 6

Abstract:

This invention is related to a method for rapidly detecting gene specific methylation through signal amplification using the epi-barcode after hybrid capture of the methylated DNA sequence.

US Patent:

20090326209, Dec 31, 2009

Filed:

Oct 9, 2008

Appl. No.:

12/287495

Inventors:

Weiwei Li - Lindenhurst NY, US
Jessica Li - Lindenhurst NY, US

International Classification:

C07H 21/04

US Classification:

536 231

Abstract:

This invention is related a method for rapidly isolating and modifying DNA from plasma/serum and body fluids. This invention provides a procedure and composition to obtain a high yield of modified DNA for methylation-specific PCR assay by coupling DNA isolation and modification courses.