Jian Hua Chen

US Patent:

6904223, Jun 7, 2005

Filed:

Apr 4, 2003

Appl. No.:

10/408073

Inventors:

Zuyun Fang - Henderson NV, US
Jianhua Wang - Saratoga CA, US
Jian J. Chen - Fremont CA, US

Assignee:

Optiworks, Inc. - Fremont CA

International Classification:

G02B006/00

US Classification:

385140, 385134

Abstract:

In a preferred embodiment, a motorized variable optical attenuator comprises an input fiber collimator; an output fiber collimator disposed substantially along the first collimator; and a right-angle reflector movable relative to the input collimator and the output collimator along a translation direction forming a non-zero angle with a direction of a light beam emitted by the input collimator. The reflector comprises two mutually-perpendicular reflective surfaces for sequentially reflecting the light beam emitted by the input collimator to the output collimator. A variable attenuation imparted by the attenuator on the light beam is determined by a position of the reflector relative to the input collimator and the output collimator, along the translation direction. The reflector preferably comprises a right-angle prism adhered to a nut mounted on a threaded axle driven by a stepper motor. The attenuator can achieve stable, ripple-free attenuation characteristics at insertion losses beyond −40 dB.

US Patent:

7034134, Apr 25, 2006

Filed:

Apr 26, 2002

Appl. No.:

10/133797

Inventors:

Shujian Wu - Langhorne PA, US
Jian Chen - Princeton NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07H 21/00
C07K 14/47

US Classification:

536 232, 435212, 435 691, 530400

Abstract:

The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

US Patent:

7073830, Jul 11, 2006

Filed:

Oct 25, 2005

Appl. No.:

11/258303

Inventors:

Jian Chen - Flushing NY, US
Dennis Q. Chen - Flushing NY, US

International Classification:

B60R 19/44

US Classification:

293142, 293109, 293126

Abstract:

A bumper protection device for automobile bumpers to shield the bumpers from impact attaches to the automobile by a fabric shroud which attaches around the hood and trunk latch and suspends an impact resisting padded guard portion, adapted to the vehicle bumper, covering the entire front or rear bumper, the padded guard portion being drawn partially around the sides of the bumper and anchored by at least one elastic strap attached to opposing ends of the bumper guard portion, each elastic strap being further attached to the tires or wheel wells of the automobile retaining the bumper protection device over the entire rear bumper surface and around the sides of the bumper.

US Patent:

7285633, Oct 23, 2007

Filed:

Dec 21, 2005

Appl. No.:

11/313356

Inventors:

Shujian Wu - Langhorne PA, US
Jian Chen - Princeton NJ, US
John N. Feder - Belle Mead NJ, US
Liana Lee - North Brunswick NJ, US
Stanley R. Krystek - Ringoes NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 38/17

US Classification:

530350

Abstract:

The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

US Patent:

8420829, Apr 16, 2013

Filed:

Apr 5, 2011

Appl. No.:

13/079888

Inventors:

Jian Chen - West Chester PA, US
Katrin Przyuski - Phoenixville PA, US
Renee Caroline Roemmele - Maple Glen PA, US

Assignee:

Cephalon, Inc. - Frazer PA

International Classification:

C07D 235/16

US Classification:

5483101

Abstract:

New methods for the preparation of bendamustine, and the pharmaceutical salts thereof, are described. Novel compounds useful for the preparation of bendamustine are also described.

US Patent:

20040014093, Jan 22, 2004

Filed:

Mar 14, 2003

Appl. No.:

10/390585

Inventors:

Franck Duclos - Washington Crossing PA, US
Jian Chen - Princeton NJ, US
John Feder - Belle Mead NJ, US
Akbar Nayeem - Newtown PA, US
Thomas Nelson - Lawrenceville NJ, US

International Classification:

C12Q001/68
G06F019/00
G01N033/48
G01N033/50
C07H021/04
C12N009/64
C12P021/02
C12N005/06

US Classification:

435/006000, 435/069100, 435/226000, 435/320100, 435/325000, 536/023200, 702/019000

Abstract:

The present invention provides novel polynucleotides encoding Protease-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel Protease-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

US Patent:

20130052711, Feb 28, 2013

Filed:

Aug 24, 2012

Appl. No.:

13/594730

Inventors:

Jian Chen - Blue Bell PA, US

International Classification:

C12M 1/42
C12N 13/00

US Classification:

4351736, 4352852

Abstract:

An apparatus for electroporation of biological cells is provided. The apparatus includes a sample container having an insulator chamber for holding the cells. The sample container has a first electrode and a second electrode to provide electrical connection for electroporation. The insulator chamber is configured to contain at least one cell monolayer. The apparatus also includes a pulse generator that can generate a predetermined pulse for electroporation of the cells.

US Patent:

54950520, Feb 27, 1996

Filed:

Sep 29, 1994

Appl. No.:

8/314843

Inventors:

Wilfred P. Shum - West Chester PA
Harry Mazurek - Bala Cynwyd PA
Jian Chen - West Chester PA

Assignee:

Arco Chemical Technology, L.P. - Greenville DE

International Classification:

C07C 4103
C07C 43205

US Classification:

568648

Abstract:

A tertiary amine is used to catalize the stereospecific ring-opening of chiral glycidol with o-methoxyphenol to afford high yields of enantiomerically enriched guaifenesin. The optical purity of the product may be even further enhanced by recrystallization.