Jian L Chen

US Patent:

8194709, Jun 5, 2012

Filed:

Jun 1, 2009

Appl. No.:

12/475674

Inventors:

Franz X. Kaertner - Newton MA, US
Hyunil Byun - Cambridge MA, US
Jian Chen - Cambridge MA, US
Erich P. Ippen - Belmont MA, US
Dominik Pudo - Quebec, CA

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

H01S 3/10

US Classification:

372 25, 372 6, 372 21, 372 99

Abstract:

Femtosecond pulse trains in waveguide lasers with high fundamental repetition rates are achieved by exploiting the nonlinearity in the waveguide. Components of the apparatus include an optical resonator, a saturable absorber for starting and stabilizing mode-locking, and a gain element. Part of the laser cavity or the entire laser cavity is made of waveguide or fiber (collectively called “waveguide” herein). The net dispersion of the laser cavity can be anomalous. This anomalous dispersion in combination with the positive self-phase modulation nonlinearity in the waveguide creates soliton formation to shorten the pulse duration in the invented lasers. Conversely, a normal dispersive waveguide with negative self-phase modulation nonlinearity can also be used.

US Patent:

8426447, Apr 23, 2013

Filed:

Sep 11, 2009

Appl. No.:

12/558426

Inventors:

Ryan White - Somerville MA, US
Albert Amegadzie - Moorpark CA, US
Marian C. Bryan - West Hills CA, US
Jian Jeffrey Chen - Camarillo CA, US
Alan C. Cheng - Cambridge MA, US
Thomas Dineen - Somerville MA, US
Oleg Epstein - Belmont MA, US
Vijay Keshav Gore - Thousand Oaks CA, US
Zihao Hua - Tewksbury MA, US
Jason Brooks Human - Boston MA, US
Hongbing Huang - Lexington MA, US
Charles Kreiman - Watertown MA, US
Daniel La - Brookline MA, US
Qingyian Liu - Camarillo CA, US
Vu Van Ma - Simi Valley CA, US
Isaac Marx - Cambridge MA, US
Vinod F Patel - Acton MA, US
Wenyuan Qian - Camarillo CA, US
Matthew Weiss - Boston MA, US
Chester Chenguang Yuan - Newbury Park CA, US

Assignee:

Amgen Inc. - Thousand Oaks CA

International Classification:

A61K 31/44
C07D 311/82
C07D 401/00
C07D 413/00

US Classification:

514336, 5462681, 5462714, 549223

Abstract:

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I.

US Patent:

8571698, Oct 29, 2013

Filed:

Jan 28, 2009

Appl. No.:

12/864870

Inventors:

Jian Chen - Cambridge MA, US
Andy Eow - Brooklyn NY, US
Xiaoxu Ma - Sunnyvale CA, US

Assignee:

NetVirta, LLC - Norwell MA

International Classification:

G06F 19/10

US Classification:

700135

Abstract:

Techniques which employ structure-from-motion modeling techniques to produce 3-D models of any desired accuracy of any surface I the techniques, a pattern is applied to the surface to be modeled The pattern includes elements which are unique within the pattern as applied to the surface and which have a density in the pattern such that when two-dimensional images are made of the surface, correlatable features having the density required for the desired accuracy may be extracted from the two dimensional images In one example of the techniques, a consumer may make the images required to produce a model of his or her body by donning a garment with a pattern having the necessary uniqueness and density, and then using any digital camera to take pictures of their body wearing the garment The model may then be produced from the pictures.

US Patent:

20060111347, May 25, 2006

Filed:

Oct 5, 2005

Appl. No.:

11/243645

Inventors:

Benny Askew - Marshfield MA, US
Toshihiro Aya - Thousand Oaks CA, US
Kaustav Biswas - Calabasas CA, US
Jian Chen - Newbury Park CA, US
Jason Human - Gasteria NC, US
Wenyuan Qian - Camarillo CA, US

Assignee:

AMGEN INC. - THOUSAND OAKS CA

International Classification:

A61K 31/5415
A61K 31/47
A61K 31/382
A61K 31/353

US Classification:

514226500, 514311000, 514432000, 514456000, 546161000, 549023000, 549403000, 544049000

Abstract:

Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

US Patent:

20080249106, Oct 9, 2008

Filed:

Apr 8, 2008

Appl. No.:

12/082076

Inventors:

Benny C. Askew - Marshfield MA, US
Jian J. Chen - Newbury Park CA, US
Derin C. D'Amico - Newbury Park CA, US
Thomas Nguyen - Thousand Oaks CA, US
Kevin Yang - San Gabriel CA, US

International Classification:

A61K 31/496
C07D 249/06
A61K 31/4192
A61K 31/454
C07D 401/08
C07D 403/08

US Classification:

51425405, 548255, 514359, 544366, 546210, 514326

Abstract:

The invention encompasses novel compounds and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.

US Patent:

20100104584, Apr 29, 2010

Filed:

Feb 14, 2008

Appl. No.:

12/526674

Inventors:

Jian Chen - Cambridge MA, US
Dan Garza - Cambridge MA, US
Hao Li - Cambridge CA, US
Susan C. Stevenson - Cambridge MA, US
Zhidan Wu - Cambridge MA, US

International Classification:

A61K 39/395
A61P 3/10
A61K 31/7052
C12Q 1/68
G01N 33/68
A61P 35/00

US Classification:

4241721, 514 44 A, 514 44 R, 435 6, 436 86

Abstract:

The invention discloses suitable gene and polypeptide targets for the development of new therapeutics to treat, prevent or ameliorate conditions associated with mitochondrial dysfunction. The invention also relates to methods to treat, prevent or ameliorate said conditions and pharmaceutical compositions therefor, as well as to a method to identify compounds with therapeutic usefulness to treat conditions associated with mitochondrial dysfunction.

US Patent:

59906278, Nov 23, 1999

Filed:

Oct 10, 1996

Appl. No.:

8/728571

Inventors:

Jian J. Chen - Beverly MA
A. Bowman Budinger - Westford MA
Walter P. Lapatovich - Boxford MA

Assignee:

Osram Sylvania, Inc. - Danvers MA

International Classification:

H05B 4136

US Classification:

315117

Abstract:

An electrodeless high intensity discharge lamp includes an electrodeless lamp capsule having an enclosed volume containing a mixture of starting gas and chemical dopant material excitable by high frequency power to a state of luminous emission, an applicator for coupling high frequency power to the lamp capsule, a gas nozzle directed toward the lamp capsule and a gas controller coupled to the gas nozzle. The gas controller receives gas from a gas source and supplies a gas puff of limited duration to the lamp capsule through the gas nozzle in response to termination of the state of luminous emission. The lamp capsule is rapidly cooled by the gas puff to a temperature required for restart.

US Patent:

20180353431, Dec 13, 2018

Filed:

Jun 12, 2018

Appl. No.:

16/006395

Inventors:

- Watertown MA, US
Jian Bing CHEN - Watertown MA, US

Assignee:

EyePoint Pharmaceuticals, Inc. - Watertown MA

International Classification:

A61K 9/28
A61K 9/20

Abstract:

This invention relates to a bioerodible drug delivery device that can be implanted in a patient at or near an area in need of treatment. The bioerodible drug delivery device can be used to deliver a wide variety of different pharmaceutically active agents, and can do so at a controlled rate and over an extended period of time. The bioerodible drug delivery device includes a bioerodible polymeric outer housing with one or more delivery ports for delivering the pharmaceutically active agent(s) contained therein. The polymer used as the bioerodible polymeric outer housing is not substantially degraded during the dosing of the pharmaceutically active agent(s) in the bioerodible drug delivery device. The invention also provides methods of making the bioerodible drug delivery device and using it for the treatment of diseases and disorders.