Jian Long Chen

US Patent:

6376506, Apr 23, 2002

Filed:

Dec 22, 1999

Appl. No.:

09/469677

Inventors:

Chris Allen Broka - Foster City CA
Jeffrey Allen Campbell - Cheshire CT
Arlindo Lucas Castelhano - New City NY
Jian Jeffrey Chen - Santa Clara CA
Robert Than Hendricks - Palo Alto CA
Michael Joseph Melnick - Ann Arbor MI
Keith Adrian Murray Walker - Los Altos Hills CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA
Agouron Pharmaceuticals, Inc. - La Jolla CA

International Classification:

A61K 31435

US Classification:

514292, 546 87

Abstract:

This invention relates to sulfamides of formula (I) that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

US Patent:

6463875, Oct 15, 2002

Filed:

Nov 15, 2000

Appl. No.:

09/711935

Inventors:

Jian J. Chen - Fremont CA
Robert G. Veltrop - Boise ID
Thomas E. Wicker - Reno NV

Assignee:

Lam Research Corporation - Fremont CA

International Classification:

H05H 146

US Classification:

118723I, 427569

Abstract:

A radio frequency plasma multiple-coil antenna allows for controllable, uniform inductive coupling within a plasma reactor. According to exemplary embodiments, multiple coils are positioned on a dielectric window of a plasma chamber, and are powered by a single radio frequency generator and tuned by a single matching network. Each coil is either planar or a combination of a planar coil and a vertically stacked helical coil. The input end of each coil is connected to an input tuning capacitor and the output end is terminated to the ground through an output tuning capacitor. The location of the maximum inductive coupling of the radio frequency to the plasma is mainly determined by the output capacitor, while the input capacitor is mainly used to adjust current magnitude into each coil. By adjusting the current magnitude and the location of the maximum inductive coupling within each coil, the plasma density in different radial and azimuthal regions can be varied and controlled, and therefore, radially and azimuthally uniform plasma can be achieved.

US Patent:

6492394, Dec 10, 2002

Filed:

Dec 22, 1999

Appl. No.:

09/469660

Inventors:

Chris Allen Broka - Foster City CA
Jeffrey Allen Campbell - Fremont CA
Jian Jeffrey Chen - Santa Clara CA
Sharon Marie Dankwardt - Foster City CA
Nancy Delaet - San Diego CA
Leslie Ann Robinson - Los Altos CA
Keith Adrian Murray Walker - Los Altos CA

Assignee:

Syntex (U.S.A.) LLC - Palo Alto CA

International Classification:

A61K 31445

US Classification:

514321, 5142275, 5142278, 5142282, 5142312, 5142338, 5142345, 5142352, 5142355, 514255, 514311, 514314, 514318, 514322, 514323, 514326, 514337, 514338, 514339, 514394, 514412, 514419, 514422, 514438, 514443, 514464, 544 584, 544124, 544128, 544139, 544143, 544153, 544159, 544363, 544370, 544373, 544377, 544386, 546193, 546197, 546199, 546201, 546229, 546264, 5462734, 5462774, 548495, 548517, 548518, 548561, 549 59, 549 75, 549 76, 549 77, 549440, 549448, 549452

Abstract:

A compound of the Formula (I): wherein Z, R , R, and Ar are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use, and methods for preparing the compounds.

US Patent:

6527912, Mar 4, 2003

Filed:

Mar 30, 2001

Appl. No.:

09/821752

Inventors:

Jian J. Chen - Fremont CA
Robert G. Veltrop - Eagle ID
Thomas E. Wicker - Reno NV

Assignee:

Lam Research Corporation - Fremont CA

International Classification:

H05H 1100

US Classification:

15634548, 118723 I

Abstract:

A radio frequency excitation coil of an inductive plasma processor includes a planar turn connected in series with a segment of the coil stacked above a portion of the planar turn. The stacked segment is placed around a region having weak radio frequency coupling to plasma due to azimuthal asymmetries in the chamber and/or the excitation coil. In a single winding embodiment, the stacked segment is close to an interconnection gap between two adjacent planar turns and extends in both directions from the gap to compensate low radio frequency coupling to plasma in the gap region. In an embodiment including two electrically parallel spatially concentric windings, the stacked segment extends beyond one side of an interconnection gap of two adjacent turns, and is aligned with the planar turn such that one end of the stacked segment is directly connected to an end of the planar turn via a straight, short stub. Terminals of the coil are connected to RF excitation circuitry terminals in a housing above the coil by leads extending smoothly and gradually without sharp bends between the coil terminals and the excitation circuitry terminals. Ends of the planar turn and the stacked segment are connected by a lead extending smoothly and gradually without sharp bends between its ends.

US Patent:

6569420, May 27, 2003

Filed:

Jul 30, 2001

Appl. No.:

09/919622

Inventors:

Jian Chen - San Mateo CA
Paul Godowski - Burlingame CA
William I. Wood - Hillsborough CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

A61K 3821

US Classification:

424 854, 424 856, 424 857, 424 851, 4241851, 424530, 424351

Abstract:

The invention concerns a novel human interferon- , originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN- family and from IFNs- and -. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production are also included.

US Patent:

6569645, May 27, 2003

Filed:

Dec 20, 2000

Appl. No.:

09/747259

Inventors:

Jian Chen - Princeton NJ
Ellen Filvaroff - San Francisco CA
Sherman Fong - Alameda CA
Audrey Goddard - San Francisco CA
Paul Godowski - Burlingame CA
Christopher Grimaldi - San Francisco CA
Austin Gurney - Belmont CA
Hanzhong Li - San Mateo CA
Kenneth Hillan - San Francisco CA
Daniel Tumas - Orinda CA
Menno VanLookeren - San Francisco CA
Richard Vandlen - Hillsborough CA
Colin Watanabe - Moraga CA
P. Mickey Williams - Half Moon Bay CA
William I. Wood - Hillsborough CA
Daniel Yansura - Pacifica CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C12N 1500

US Classification:

435 6952, 4353201, 4352523, 435325, 435 6, 536 235, 530351

Abstract:

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

US Patent:

6579520, Jun 17, 2003

Filed:

Mar 22, 2001

Appl. No.:

09/816744

Inventors:

Jian Chen - Princeton NJ
Ellen Filvaroff - San Francisco CA
Sherman Fong - Alameda CA
Audrey Goddard - San Francisco CA
Paul Godowski - Burlingame CA
Christopher Grimaldi - San Francisco CA
Austin Gurney - Belmont CA
Hanzhong Li - San Mateo CA
Kenneth Hillan - San Francisco CA
Daniel Tumas - Orinda CA
Menno VanLookeren - San Francisco CA
Richard Vandlen - Hillsborough CA
Colin Watanabe - Moraga CA
P. Mickey Williams - Half Moon Bay CA
William I. Wood - Hillsborough CA
Daniel Yansura - Pacifica CA

Assignee:

Genentech, Inc. - South San Francisco

International Classification:

A61K 4505

US Classification:

424 852, 530351, 5303873, 435 697

Abstract:

The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

US Patent:

6580868, Jun 17, 2003

Filed:

Mar 19, 2001

Appl. No.:

09/812358

Inventors:

Jian J. Chen - Fremont CA
Jianhua Wang - Milpitas CA

Assignee:

Optiwork, Inc. - Fremont CA

International Classification:

G02B 600

US Classification:

385140, 385 36, 359227

Abstract:

A mechanically-adjustable variable optical attenuator includes a beam attenuator shaped as a concave quasi-cone. The beam attenuator has a sharp tip and a base, and can be rotationally symmetric with respect to a central axis extending between the tip and the base. The beam attenuator is positioned with its central axis perpendicular to the direction of the light beam to be attenuated. The extent of the beam attenuator obstructing the light beam is varied by moving the beam attenuator into and out of the light beam. The inwardly-curving, quasi-cone shape of the beam attenuator allows achieving a high resolution while limiting the beam attenuator size.