Jian N Chen

US Patent:

6569645, May 27, 2003

Filed:

Dec 20, 2000

Appl. No.:

09/747259

Inventors:

Jian Chen - Princeton NJ
Ellen Filvaroff - San Francisco CA
Sherman Fong - Alameda CA
Audrey Goddard - San Francisco CA
Paul Godowski - Burlingame CA
Christopher Grimaldi - San Francisco CA
Austin Gurney - Belmont CA
Hanzhong Li - San Mateo CA
Kenneth Hillan - San Francisco CA
Daniel Tumas - Orinda CA
Menno VanLookeren - San Francisco CA
Richard Vandlen - Hillsborough CA
Colin Watanabe - Moraga CA
P. Mickey Williams - Half Moon Bay CA
William I. Wood - Hillsborough CA
Daniel Yansura - Pacifica CA

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C12N 1500

US Classification:

435 6952, 4353201, 4352523, 435325, 435 6, 536 235, 530351

Abstract:

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

US Patent:

6579520, Jun 17, 2003

Filed:

Mar 22, 2001

Appl. No.:

09/816744

Inventors:

Jian Chen - Princeton NJ
Ellen Filvaroff - San Francisco CA
Sherman Fong - Alameda CA
Audrey Goddard - San Francisco CA
Paul Godowski - Burlingame CA
Christopher Grimaldi - San Francisco CA
Austin Gurney - Belmont CA
Hanzhong Li - San Mateo CA
Kenneth Hillan - San Francisco CA
Daniel Tumas - Orinda CA
Menno VanLookeren - San Francisco CA
Richard Vandlen - Hillsborough CA
Colin Watanabe - Moraga CA
P. Mickey Williams - Half Moon Bay CA
William I. Wood - Hillsborough CA
Daniel Yansura - Pacifica CA

Assignee:

Genentech, Inc. - South San Francisco

International Classification:

A61K 4505

US Classification:

424 852, 530351, 5303873, 435 697

Abstract:

The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

US Patent:

6642041, Nov 4, 2003

Filed:

Feb 5, 2002

Appl. No.:

10/067443

Inventors:

Jian Chen - Princeton NJ
John N. Feder - Belle Mead NJ
Thomas C. Nelson - Lawrenceville NJ
Stanley R. Krystek - Ringoes NJ
Franck Duclos - Washington Crossing PA

Assignee:

Bristol-Meyers Squibb Company - Princeton NJ

International Classification:

C12N 948

US Classification:

435226, 4352523, 4353201, 435219, 536 232

Abstract:

The present invention provides novel polynucleotides encoding MP-1 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MP-1 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

US Patent:

7034134, Apr 25, 2006

Filed:

Apr 26, 2002

Appl. No.:

10/133797

Inventors:

Shujian Wu - Langhorne PA, US
Jian Chen - Princeton NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07H 21/00
C07K 14/47

US Classification:

536 232, 435212, 435 691, 530400

Abstract:

The present invention provides novel polynucleotides encoding MMP-29 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel MMP-29 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

US Patent:

7037676, May 2, 2006

Filed:

Mar 20, 2001

Appl. No.:

09/813329

Inventors:

Pamela M. Carroll - Princeton NJ, US
Jian Chen - Princeton NJ, US
Chandra S. Ramanathan - Wallingford CT, US
Hong Xiao - Princeton Junction NJ, US
Michael A. Bowen - Lawrenceville NJ, US

Assignee:

Bristol-Myers Squibb - Princeton NJ

International Classification:

C12P 21/06
C12N 15/09
C12N 15/19
C07H 21/04

US Classification:

435 691, 435 701, 435 695, 435 697, 4353201, 435325, 536 231, 536 234, 536 243, 4241851, 4241921

Abstract:

The present invention provides novel polynucleotides encoding DmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two Drosophila DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying Drosophila or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.

US Patent:

7056737, Jun 6, 2006

Filed:

Feb 13, 2002

Appl. No.:

10/075846

Inventors:

John N. Feder - Belle Mead NJ, US
Liana Lee - North Brunswick NJ, US
Jian Chen - Princeton NJ, US
Nathan O. Siemers - Pennington NJ, US
Han Chang - Princeton Junction NJ, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12N 5/00

US Classification:

435325, 4353201, 4352523, 435 6, 536 235

Abstract:

The present invention provides novel polynucleotides encoding HGRA4 polypeptides, fragments and homologues thereof. The present invention also provides novel polynucleotides encoding a HGRA4 splice variant, HGRA4sv. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGRA4 and HGRA4sv polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

US Patent:

7115398, Oct 3, 2006

Filed:

May 10, 2001

Appl. No.:

09/854280

Inventors:

Jian Chen - Princeton NJ, US
Ellen Filvaroff - San Francisco CA, US
Audrey Goddard - San Francisco CA, US
Austin Gurney - Belmont CA, US
Hanzhong Li - San Mateo CA, US
William I. Wood - Hillsborough CA, US

Assignee:

Genentch, Inc. - South San Francisco CA

International Classification:

C12P 21/04

US Classification:

435 6952, 4353201, 4352523, 435325, 435 6, 536 235, 530351

Abstract:

The present invention is directed to novel polypeptides having sequence identity with IL-17 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders.

US Patent:

7125962, Oct 24, 2006

Filed:

Jun 18, 2002

Appl. No.:

10/174576

Inventors:

Kevin P. Baker - Damestown MD, US
Jian Chen - Princeton NJ, US
Luc Desnoyers - San Francisco CA, US
Audrey Goddard - San Francisco CA, US
Paul J. Godowski - Hillsborough CA, US
Austin L. Gurney - Belmont CA, US
James Pan - Belmont CA, US
Victoria Smith - Burlingame CA, US
Colin K. Watanabe - Moraga CA, US
William I. Wood - Hillsborough CA, US
Zemin Zhang - Foster City CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07K 16/00
C07K 14/00

US Classification:

5303879, 530300, 530351, 5303871, 5303881, 436512, 436532, 435 71, 435331

Abstract:

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Address:

2014 Carmel Dr, Jamison, PA 18929

VIN:

2T2HK31U27C046571

Make:

LEXUS

Model:

RX 350

Year:

2007