Jian Fang Lin

US Patent:

7411719, Aug 12, 2008

Filed:

Jun 21, 2005

Appl. No.:

11/160364

Inventors:

David Miller - Wakefield MA, US
Barrett Comiskey - Shanghai, CN
Joseph M. Jacobson - Newton Centre MA, US
Bin Wu - Sharon MA, US
Charles Howie Honeyman - Roslindale MA, US
Jian Lin - Acton MA, US

Assignee:

E Ink Corporation - Cambridge MA

International Classification:

G02B 26/00
G09G 3/34
G03G 13/04

US Classification:

359296, 345107, 430 32

Abstract:

A two-phase electrophoretic medium comprises a continuous phase and a discontinuous phase. The discontinuous phase comprises a plurality of droplets, each of which comprises a suspending fluid and at least one particle disposed within the suspending fluid and capable of moving through the fluid upon application of an electric field to the electrophoretic medium. The continuous phase surrounds and encapsulates the discontinuous phase. To reduce the humidity sensitivity of the medium, a non-ionizable or crystalline polymer may be used as the continuous phase.

US Patent:

7848007, Dec 7, 2010

Filed:

Jul 3, 2008

Appl. No.:

12/167290

Inventors:

David D. Miller - Wakefield MA, US
Barrett Comiskey - Shanghai, CN
Joseph M. Jacobson - Newton Centre MA, US
Bin Wu - Sharon MA, US
Charles Howie Honeyman - Roslindale MA, US
Jian Lin - Acton MA, US

Assignee:

E Ink Corporation - Cambridge MA

International Classification:

G02B 26/00
G03G 17/04

US Classification:

359296, 430 32

Abstract:

A two-phase electrophoretic medium comprises a continuous phase and a discontinuous phase. The discontinuous phase comprises a plurality of droplets, each of which comprises a suspending fluid and at least one particle disposed within the suspending fluid and capable of moving through the fluid upon application of an electric field to the electrophoretic medium. The continuous phase surrounds and encapsulates the discontinuous phase. To reduce the humidity sensitivity of the medium, a non-ionizable or crystalline polymer may be used as the continuous phase.

US Patent:

8569282, Oct 29, 2013

Filed:

Dec 11, 2008

Appl. No.:

12/747109

Inventors:

Efrat Ben-Zeev - K. Motzkin, IL
Dongli Chen - Brighton MA, US
Merav Fichman - Modi'in, IL
Shomir Ghosh - Brookline MA, US
Steffi Koerner - Medford MA, US
Jian Lin - Acton MA, US
Yael Marantz - Kadima, IL
Rosa E. Melendez - Toronto, CA
Pradyumna Mohanty - Woburn MA, US
Sharon Shacham - Chestnut Hill MA, US
Zhaoda Zhang - Andover MA, US

Assignee:

CytoPathfinder, Inc. - Tokyo

International Classification:

C07D 471/04
A61K 31/4375

US Classification:

51421018, 514312, 514320, 5142305, 514309, 514403, 514375, 514321, 5142531, 544105, 544364, 546157, 546196, 546141, 5483625, 548221

Abstract:

Chemokine receptor antagonists, in particular, compounds of Formula (I-A) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.

US Patent:

20080146811, Jun 19, 2008

Filed:

Jul 22, 2005

Appl. No.:

11/658121

Inventors:

Hongfeng Deng - Acton MA, US
Jian Lin - Walpole MA, US
Zihong Guo - Southbury CT, US
Harold V. Meyers - Weston MA, US
Sherin S. Abdel-Meguid - Exton PA, US
Robert E. Babine - Carlsbad CA, US

International Classification:

C07D 401/12
C07D 209/14

US Classification:

5462774, 548495

Abstract:

The invention provides compounds, pharmaceutical compositions, and methods for the treatment of thromboembolic disorders, such as, for example, arterial cardiovascular thromboembolic disorders, venous cardiovascular thromboembolic disorders, or thromboembolic disorders in the chambers of the heart.

US Patent:

20100184749, Jul 22, 2010

Filed:

Oct 12, 2007

Appl. No.:

12/445149

Inventors:

Merav Fichman - Modi'in, IL
Rosa E. Melendez - Woburn MA, US
Pradyumna Mohanty - Woburn MA, US
Jian Lin - Walpole MA, US
Dilara McCauley - Cambridge MA, US
Boaz Inbal - Kfar Shmuel, IL
Mercedes Lobera - Bolton MA, US
Pini Orbach - Tel Mond, IL
Ori Kalid - Tel Aviv, IL
Dongli Chen - Brighton MA, US
Yael Marantz - Kadima, IL
Michael Xie - Natick MA, US
Sharon Shacham - Chestnut Hill MA, US
Oren Becker - Mevaseret Zion, IL

Assignee:

EPIX Delaware ,Inc. - Lexington MA

International Classification:

A61K 31/549
C07D 417/06
A61P 37/06
A61P 17/06
A61P 19/02
A61P 9/10
A61P 11/00
A61P 13/12
A61P 1/16
A61P 3/10

US Classification:

5142228, 544 11

Abstract:

Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.

US Patent:

20100210633, Aug 19, 2010

Filed:

Oct 12, 2007

Appl. No.:

12/445134

Inventors:

Jian Lin - Acton MA, US
Dongli Chen - Brighton MA, US
Steffi Koerner - Medford MA, US
Rosa E. Melendez - Woburn MA, US
Efrat Ben-Zeev - K. Motzkin, IL
Merav Fichman - Modi'i, IL
Yael Marantz - Kadima, IL
Oren Becker - Mevaseret Zion, IL
Dilara McCauley - Cambridge MA, US
Pini Orbach - Tel Mond, IL
Ashis K. Saha - Stow MA, US
Sharon Shacham - Chestnut Hill MA, US
Michael Xie - Natick MA, US

Assignee:

EPIX Delaware, Inc. - Lexington MA

International Classification:

A61K 31/541
C07D 405/06
A61K 31/453
A61P 3/10
A61P 3/04
A61P 37/06
A61P 17/06
A61P 9/10
A61P 13/12
A61P 1/16
C07D 211/62
A61K 31/445
C07D 207/16
A61K 31/40
A61K 31/4525
C07D 413/10
A61K 31/454
C07D 405/14
A61K 31/496
C07D 401/06
A61K 31/4545
C07D 401/04
C07D 417/06
C07D 413/06
A61K 31/5377

US Classification:

5142278, 546207, 514326, 546225, 514330, 548537, 514423, 546197, 514321, 546199, 514322, 544364, 51425311, 546189, 514316, 546194, 514318, 544 582, 544130, 5142355, 5142368

Abstract:

Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.

US Patent:

20100331298, Dec 30, 2010

Filed:

Dec 10, 2008

Appl. No.:

12/747106

Inventors:

Efrat Ben-Zeev - K. Motzkin, IL
Dongli Chen - Brighton MA, US
Merav Fichman - Modi'in, IL
Shomir Ghosh - Brookline MA, US
Steffi Koerner - Medford MA, US
Jian Lin - Acton MA, US
Yael Marantz - Kadima, IL
Rosa E. Melendez - Toronto, CA
Pradyumna Mohanty - Woburn MA, US
Sharon Shacham - Chestnut Hill MA, US
Zhaoda Zhang - Andover MA, US

Assignee:

CytoPathfinder, Inc. - Chuo-ku

International Classification:

A61K 31/538
C07D 401/06
C07D 405/06
C07D 413/06
C07D 403/06
C07D 417/06
C07D 413/14
A61K 31/4709
A61K 31/453
A61K 31/454
A61K 31/4725
A61K 31/416
A61K 31/423
A61K 31/496
A61P 19/02
A61P 29/00
A61P 17/06
A61P 9/10
A61P 37/06
A61P 3/10
A61P 3/00
A61P 3/04

US Classification:

51421018, 546157, 546196, 544105, 546141, 5483625, 544364, 514312, 514320, 5142305, 514309, 514403, 548221, 514375, 514321, 5142531

Abstract:

Chemokine receptor antagonists, in particular, compounds of Formula (I) that act as antagonists of the chemokine CCR2 receptor, including pharmaceutical compositions and uses thereof to treat or prevent diseases associated with monocyte accumulation, lymphocyte accumulation or leukocyte accumulation are described herein.

US Patent:

20130273034, Oct 17, 2013

Filed:

Sep 2, 2011

Appl. No.:

13/820496

Inventors:

Kenneth W. Bair - Watertown MA, US
Timm R. Baumeister - Watertown MA, US
Alexandre J. Buckmelter - Watertown MA, US
Karl H. Clodfelter - Watertown MA, US
Bingsong Han - Watertown MA, US
Jian Lin - Watertown MA, US
Dominic J. Reynolds - Watertown MA, US
Chase C. Smith - Watertown MA, US
Zhongguo Wang - Watertown MA, US
Xiaozhang Zheng - Watertown MA, US
Po-Wai Yuen - Beijing, CN

International Classification:

C07D 401/12
C07D 213/40
A61K 31/4406
A61K 45/06
C07D 471/04
A61K 31/437
C07D 213/74
A61K 31/44
A61K 31/4545
A61K 31/5377

US Classification:

4241331, 546194, 514318, 546331, 514357, 544130, 5142355, 546121, 514300, 546306, 514353, 424649, 514171, 514 34, 424 946, 514 193, 514274

Abstract:

The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: