Jian L Lin

US Patent:

20130305396, Nov 14, 2013

Filed:

Sep 28, 2011

Appl. No.:

13/876232

Inventors:

Luigi Grasso - Bryn Mawr PA, US
Jian Min Lin - Malvern PA, US
Yuhong Zhou - Phoenixville PA, US
Brian E. Tomkowicz - East Norriton PA, US
Nicholas C. Nicolaides - Glen Mills PA, US
Philip M. Sass - Audubon PA, US

International Classification:

A61K 49/00

US Classification:

800 3, 800 18, 435354, 435 723

Abstract:

Provided herein are rodents that express the human endosialin gene. In preferred embodiments, the rodent is a mouse. Preferably, the human endosialin gene is integrated into the native or endogenous endosialin gene locus. More preferably, the host rodent is null for the endogenous endosialin gene product. The human endosialin gene is preferably expressed in a similar development and disease response pattern as that of the native endosialin gene product in parental or wild type rodents. This feature makes these rodents useful for studying the effects of test agents to positively or negatively affect endosialin biology for therapeutic use. Use of human endosialin expressing rodents lacking native endosialin gene product (HUE rodents) is proposed as a strategy for developing agents that can positively or negatively affect the endosialin pathway and also serve as a screening tool to identify those agents that may be useful as human therapies.