Papillomavirus-like particles (VLPs) comprising truncated L1 proteins are provided wherein the L1 proteins have one or more carboxy terminal amino acid residues deleted.
Papilloma Virus-Like Particles, Fusion Proteins As Well As Processes For Their Production
The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
Papilloma Virus-Like Particles, Fusion Proteins As Well As Processes For Their Production
Lutz Gissmann - Wiesloch, DE Jian Zhou - Willowbrook IL, US Martin Muller - Neckargemund, DE Jeanette Painstil - Burr Ridge IL, US
Assignee:
Loyola University of Chicago - Chicago IL
International Classification:
A61K 39/12
US Classification:
4242041, 4242051, 4241841
Abstract:
The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
Papilloma Virus-Like Particles, Fusion Proteins As Well As Processes For Their Production
Lutz Gissmann - Willowbrook IL, US Jian Zhou - Willowbrook IL, US Martin Muller - Chicago IL, US Jeanette Painstil - Westchester IL, US
Assignee:
Loyola University of Chicago
International Classification:
A61K039/12 C12N007/00
US Classification:
424/204100, 435/235100
Abstract:
The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
Papilloma Virus-Like Particles, Fusion Proteins As Well As Processes For Their Production
Lutz Gissmann - Willowbrook IL, US Jian Zhou - Willowbrook IL, US Martin Muller - Chicago IL, US Jeanette Painstil - Westchester IL, US
Assignee:
LOYOLA UNIVERSITY OF CHICAGO - Chicago IL
International Classification:
C07K 14/025
US Classification:
530403
Abstract:
The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.
Carboxyl Terminal Of Papilloma Virus L1 Region Is Not Required For Formation Of Virus-Like Particles
Lutz Gissmann - Willowbrook IL Jian Zhou - Willowbrook IL Martin Muller - Chicago IL Jeanette Painstil - Westchester IL
Assignee:
Loyola University of Chicago - Chicago IL
International Classification:
A61K 3912
US Classification:
4242041
Abstract:
Recombinant papilloma virus-like particles result from the expression of viral structural protein L1 and/or L2 in which one or several sections of the L1 and/or L2 protein are deleted. The ability to form virus-like particles is at least the same as, preferably higher than, that of native reproduction and/or in vitro production processes.
This invention relates to a recombinant papilloma virus L1 protein which can elicit an immune response which recognises papilloma virus VLP including L1 protein and can form extracellularly a multimeric structure or VLP wherein the multimeric structure comprises a plurality of recombinant papilloma virus L1 proteins. This invention also includes the use of the recombinant papilloma virus L1 protein to detect the presence of papilloma virus and can form the basis of a vaccine for prophylactic and therapeutic use.
Adaptive Ultrasound Deep Convolution Neural Network Denoising Using Noise Characteristic Information
- Tochigi, JP Jian ZHOU - Vernon Hills IL, US Ting XIA - Vernon Hills IL, US Zhou YU - Vernon Hills IL, US Tomohisa IMAMURA - Otawara, JP Ryosuke IWASAKI - Otawara, JP Hiroki TAKAHASHI - Nasushiobara, JP
Assignee:
CANON MEDICAL SYSTEMS CORPORATION - Tochigi
International Classification:
G16H 30/40 A61B 8/08 G06T 5/00 G06N 3/08
Abstract:
A method and system enable to-be-processed medical image data and its corresponding noise characteristic information to be normalized to resemble noise characteristic information of training data used to train at least one neural network for at least one ultrasound data acquisition mode. After normalizing, this processed medical image data is input into the trained neural network for producing output data used for generating cleaner images. Noise characteristic information can be used directly in training a neural network, generating a trained neural network that can handle medical image data with various noise characteristics.
Illinois Neurological Institute 200 E Pennsylvania Ave STE 101, Peoria, IL 61603 3096244000 (phone), 3096244010 (fax)
Procedures:
Physical Therapy Physical Therapy Evaluation
Languages:
English Spanish
Description:
Dr. Zhou works in Peoria, IL and specializes in Physical Medicine & Rehabilitation. Dr. Zhou is affiliated with OSF Saint Francis Medical Center and Unitypoint Health Proctor Hospital.
Name / Title
Company / Classification
Phones & Addresses
Jian Xiang Zhou President
Fuanna Trading Group
1360 College Vw Dr, Monterey Park, CA 91754
Jian Zhou President
Evergreen Technology Inc
19945 Harrison Ave, Walnut, CA 91789
Jian Wen Zhou President
San Gabriel Yum Cha Cafe, Inc
566 Monterey Pass Rd, Monterey Park, CA 91754 10024 Giovane St, El Monte, CA 91733
Jian Wen Zhou President
YUM CHA CAFE (MPK), INC
566 Monterey Pass Rd, Monterey Park, CA 91754 10024 Giovane St, El Monte, CA 91733
Jian Wen Zhou President
YUM CHA CAFE WESTMINSTER, INC
10024 Giovane St, South El Monte, CA 91733 566 Monterey Pass Rd, Monterey Park, CA 91754
Jian Wen Zhou President
YUM CHA CAFE ROSEMEAD, INC
10024 Giovane St, South El Monte, CA 91733 566 Monterey Pass Rd, Monterey Park, CA 91754
Jian Zhou President
Billiontree Technology USA Inc Nonclassifiable Establishments
19949 Harrison Ave, Walnut, CA 91789
Jian Wen Zhou President
WEST COVINA YUM CHA CAFE, INC Eating Place
10024 Giovane St, South El Monte, CA 91733 566 Monterey Pass Rd, Monterey Park, CA 91754 987 S Glendora Ave, West Covina, CA 91790 6263388868
Navy Federal Credit Union
Digital Engineer V
Dstorm Technologies
Founder, Software Architect and Senior Software Engineer
Dstorm Technologies Nov 1, 2015 - Aug 2016
Software Architect and Senior Software Engineer
Inspur Group Co., Ltd. Aug 2015 - Nov 2015
Big Data Platform Architect
Lionbridge Nov 2013 - Jul 2015
Project Manager
Education:
Shanghai Fisheries University 1995 - 1999
Bachelors, Biology
Skills:
.Net Microsoft Sql Server Ssis C# Visual Studio Asp.net Mvc Web Services Data Warehousing Entity Framework T Sql Requirements Analysis Javascript Solution Architecture Java Microsoft Azure Cloud Computing Hadoop Proposal Writing Requirements Gathering Microsoft Power Bi Css Linux Presto Machine Learning Amazon Web Services Python Dax Hdinsight Asp.net Soa Xml Wcf Ssrs Jquery Redis Apache Kafka Apache Storm Mongodb Subversion Stored Procedures Windows Server 2008 Tfs Mysql Ooad Enterprise Library Ado.net Technical Project Delivery Database Modeling Windows Services Ssas Olap Wordpress Html Analysis Services Linq Ajax Angularjs Node.js
Interests:
Digital Photography Running Long Distance Running
Languages:
English Mandarin
Certifications:
Shaping Up With Angularjs Staying Sharp With Angularjs Real-Time Web With Node.js Mcts: .Net Framework 3.5, Asp.net Applications Mcpd: Asp.net Developer 3.5 Mcps: Microsoft Certified Professional Intermediate R Writing Functions In R Intermediate R - Practice Object-Oriented Programming In R: S3 and R6 Importing Data In R (Part 1) Importing Data In R (Part 2) Cleaning Data In R Importing & Cleaning Data In R: Case Studies Data Manipulation In R With Dplyr Joining Data In R With Dplyr Manipulating Time Series Data In R With Xts Data Visualization With Ggplot2 (Part 1) Microsoft Specialist - Design and Implement Big Data Analytics Solutions Microsoft Dat225X: Developing A Sql Server Analysis Services Tabular Data Model Python Programming Track Python Programmer Track Statistical Thinking In Python (Part 1) Statistical Thinking In Python (Part 2) License 7282594 Code School Microsoft, License 7282594
University of California, Davis - Davis since Apr 2012
Assistant Project Scientist
University of California, Davis Sep 2008 - Jun 2012
Postdoctoral Scholar
INSERM - Rennes, France Oct 2006 - Jun 2008
Postdoctor
Education:
Southeast University
Ph.D., Biomedical Engineering
Southeast University
M.S., Signal and Information Processing
Southeast University
B.S., Telecommunication
Skills:
Image Analysis Medical Imaging Signal Processing Algorithms Biomedical Engineering Machine Learning Mathematical Modeling Matlab Neuroscience Science Physics Latex Experimentation
Jian Zhou, Ryan OHara, Harini P. Tirumala, Mark A. Durham, Alexander J. Trostle, Michelle Dias, Yingyao Shao, Hu Chen, Wei Wang, Hari K. Yalamanchili, Ying-Wooi Wan, Laura A. Banaszynski and Zhandong Liu also contributed to this work.