Jiangbo Wang from 105 Big Meadows Pl, Chapel Hill, NC 27514, age 51

Smoothened Receptor Modulators
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US Patent:

20120094974, Apr 19, 2012
Filed:

Jun 16, 2009
Appl. No.:

12/737044
Inventors:

Wei Chen - Durham NC, US
Lawrence Barak - Durham NC, US
H. Kim Lyerly - Durham NC, US
Jiangbo Wang - Durham NC, US
International Classification:

A61K 31/454
A61K 31/5377
A61K 31/55
A61K 31/553
A61P 35/00
A61K 31/551
A61K 31/4545
A61K 31/426
A61K 31/4439
A61K 31/538
A61K 31/506
A61K 31/4725
US Classification:

51421021, 51425218, 51425214, 5142355, 514318, 51421704, 51421115, 514307, 514218, 514365, 514342, 5142305
Abstract:

The present invention relates, in general, to the Smoothened receptor and, in particular, to a method of modulating Smoothened receptor activity and to compounds and compositions suitable for use in such a method.

Radiolabled Cyclopamine Assay For The Smoothened Receptor
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US Patent:

20110236907, Sep 29, 2011
Filed:

Jun 16, 2009
Appl. No.:

12/999922
Inventors:

Wei Chen - Chapel Hill NC, US
Lawrence S. Barak - Durham NC, US
Jiangbo Wang - Durham NC, US
Robert J. Lefkowitz - Durham NC, US
Herbert Kim Lyerly - Chapel Hill NC, US
International Classification:

G01N 23/00
US Classification:

435 72
Abstract:

The present invention discloses novel methods for screening compositions for both agonist and antagonist activity on the smoothened receptor. The assay tests ligands on the activity of the receptor using a cyclopamine binding and ultra high receptor expression.

Chemical Modulators Of Signaling Pathways And Therapeutic Use
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US Patent:

20200038350, Feb 6, 2020
Filed:

Jun 24, 2016
Appl. No.:

15/739390
Inventors:

- Durham NC, US
Jiangbo Wang - Durham NC, US
Minyong Chen - Durham NC, US
Lawrence S. Barak - Durham NC, US
Herbert Kim Lyerly - Chapel Hill NC, US
David Needham - Durham NC, US
International Classification:

A61K 31/167
A61K 9/00
A61P 35/00
A61P 1/16
A61K 31/4188
A61K 31/5375
A61K 31/47
A61K 31/18
A61K 31/196
A61K 31/4015
A61K 31/536
Abstract:

Described are methods of treating a disease associated with dysregulation of the Wnt/Frizzled signaling pathway. The methods include identifying subjects in need of therapy, administering inhibitors of the Wnt/Frizzled signaling pathway, pharmaceutical compositions including the inhibitors, and methods of using the compounds and compositions for treating cancer, bacterial and viral infection, lupus, type II diabetes, nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) in a subject.

Niclosamide-Conjugated Polypeptide Nanoparticles
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US Patent:

20190083638, Mar 21, 2019
Filed:

Jul 25, 2018
Appl. No.:

16/045556
Inventors:

- Durham NC, US
Jayanta Bhattacharyya - Durham NC, US
Robert A. Mook - Chapel Hill NC, US
Jiangbo Wang - Durham NC, US
Ivan Spasojevic - Durham NC, US
Richard Premont - Durham NC, US
Xinghai Li - Durham NC, US
Ashutosh Chilkoti - Durham NC, US
International Classification:

A61K 47/64
A61K 31/167
A61P 35/00
A61P 19/02
A61P 3/08
A61K 47/69
Abstract:

Disclosed herein are conjugates of a therapeutic compound and polypeptides, such as a conjugate of niclosamide and an elastin-like polypeptide. These conjugates may form nanoparticles through self-assembly, which improve the solubility, bioavailability, and pharmacokinetic profiles of the therapeutic compound. Also disclosed are methods for treating cancer, parasite infection, bacterial infection, viral infection, metabolic diseases, Type II diabetes, NASH, NAFLD, artery constriction, endometriosis, neuropathic pain, rheumatoid arthritis, sclerodermatous graft-versus-host disease, and systemic sclerosis.

Chemical Modulators Of Immune Checkpoints And Therapeutic Use
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US Patent:

20190077772, Mar 14, 2019
Filed:

Nov 14, 2018
Appl. No.:

16/191243
Inventors:

- Durham NC, US
Herbert Kim Lyerly - Chapel Hill NC, US
Jiangbo Wang - Durham NC, US
Hongtao Guo - Durham NC, US
Amy Hobeika - Durham NC, US
Robert A. Mook - Chapel Hill NC, US
International Classification:

C07D 249/08
A61K 45/06
A61K 31/4184
C07D 235/18
A61K 31/4196
Abstract:

Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The methods are useful for treating cancer and viral infection in a subject.

New Methods Of Use For An Anti-Diarrhea Agent
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US Patent:

20190070154, Mar 7, 2019
Filed:

Jun 24, 2016
Appl. No.:

15/739396
Inventors:

- Durham NC, US
Jiangbo Wang - Durham NC, US
Minyong Chen - Durham NC, US
Lawrence S. Barak - Durham NC, US
Herbert Kim Lyerly - Chapel Hill NC, US
International Classification:

A61K 31/44
A61K 45/06
A61K 31/426
A61K 39/395
A61K 33/24
A61K 31/282
Abstract:

Described are methods of treating a disease associated with dysregulation of the Wnt/Frizzled signaling pathway. The methods include identifying subjects in need of therapy, administering inhibitors of the Wnt/Frizzled signaling pathway, pharmaceutical compositions including the inhibitors, and methods of using the compounds and compositions for treating cancer, bacterial Sand viral infection, lupus, type II diabetes, nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD) in a subject.

Chemical Modulators Of Immune Checkpoints And Therapeutic Use
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US Patent:

20170190675, Jul 6, 2017
Filed:

Dec 30, 2016
Appl. No.:

15/395464
Inventors:

- Durham NC, US
Herbert Kim Lyerly - Chapel Hill NC, US
Jiangbo Wang - Durham NC, US
Hongtao Guo - Durham NC, US
Amy Hobeika - Durham NC, US
Robert A. Mook - Chapel Hill NC, US
International Classification:

C07D 249/08
A61K 45/06
A61K 31/4184
C07D 235/18
A61K 31/4196
Abstract:

Compounds and pharmaceutical compositions that down-regulate immune checkpoints such as PD-1, PD-L1 and CTLA-4 are provided. Also provided are methods of treating a disease by down-regulating immune checkpoints such as PD-1, PD-L1 and CTLA-4. The methods are useful for treating cancer and viral infection in a subject.

Smoothened Modulators And Methods Of Use Thereof
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US Patent:

20150166509, Jun 18, 2015
Filed:

Sep 16, 2013
Appl. No.:

14/405614
Inventors:

- Durham NC, US
Jiangbo Wang - Durham NC, US
Lawrence S. Barak - Durham NC, US
H. Kim Lyerly - Durham NC, US
Anthony Angelo Ribeiro - Durham NC, US
International Classification:

C07D 401/14
C12N 5/0793
Abstract:

Compounds of general Formulas (I), (IA), (IB) are described, along with compositions containing the same and methods of use thereof, inhibiting the hedgehog pathway in a cell or inhibiting unwanted proliferation of a cell.