Jie C Chen

US Patent:

6381197, Apr 30, 2002

Filed:

Mar 8, 2000

Appl. No.:

09/521393

Inventors:

Bernard J Savord - Andover MA 01810
William J Ossmann - Acton MA 01720
Jie Chen - North Andover MA 01845
Michael P Anthony - Andover MA 01810
Turuvekere R Gururaja - Parkvale Drive Discovery Bay, HK
Stephen M Grenon - Hillsborough NC 27278

International Classification:

H04R 1700

US Classification:

367178

Abstract:

A micro-machined ultrasonic transducer (MUT) having aperture, elevation and apodization controlled by apparatus located on the same substrate as the transducer, or by bias voltage control applied to MUT elements, allows for an efficient and compact ultrasonic probe. The control apparatus may take the form of field effect transistors (FETs), micro-machined relays, or doped regions on the substrate, or any other apparatus that may be located on the same substrate as that of the transducer, or by bias voltage sources connected to the MUT elements.

US Patent:

6425869, Jul 30, 2002

Filed:

Jul 18, 2000

Appl. No.:

09/618350

Inventors:

Patrick G Rafter - Windham NH
Jodi Lisa Tuck Perry - Methuen MA
Jie Chen - North Andover MA

Assignee:

Koninklijke Philips Electronics, N.V. - Eindhoven

International Classification:

A61B 814

US Classification:

600458

Abstract:

A system and method for ultrasonic harmonic imaging of both tissue and tissue perfused with a contrast agent are disclosed. The ultrasonic harmonic imaging system comprises a wideband phased-array transducer, a transmitter for transmitting waves into the tissue, a receiver for receiving ultrasonic responses from the tissue, a control system electrically coupled to the transmitter and the receiver for controlling operation of the transmitter and receiver, a video processor, and a monitor. In a preferred embodiment, the transducer insonifies tissue at a fundamental frequency of less than approximately 1. 5 MHz. A method for detecting an ultrasonic harmonic response of a contrast agent may be performed by introducing at least one contrast agent into the target object, destroying the contrast agent with an ultrasonic pressure wave and measuring the harmonic response from the destroyed contrast agent. A method for detecting an ultrasonic harmonic tissue response may be performed by insonifying the tissue at a low frequency for increased uniformity in depth and using transmit apodization of a wideband phased-array transducer to improve harmonic generation in the near-field.

US Patent:

6465937, Oct 15, 2002

Filed:

Mar 8, 2000

Appl. No.:

09/521167

Inventors:

Jie Chen - North Andover MA
Rajesh Kumar Panda - Nashua NH
Turuvekere R Gururaja - Discovery Bay, HK
Heather Beck - Clemsford MA

Assignee:

Koninklijke Philips Electronics N.V. - Eindhoven

International Classification:

H01L 4104

US Classification:

310360

Abstract:

This invention is directed to a transducer comprising a lead-based single crystal wherein the crystal is diagonally oriented and has an effective coupling constant of at least 0. 70. In one embodiment, the lead-based crystal has the formula Pb(BâBâ)O âPbTiO wherein Bâ is Mg , Zn , Ni or Sc and Bâ is Nb , Ta or W. Preferably, the lead-based crystal has of the formula Pb(BâBâ)O âPbTiO where Bâ is Mg , Zn , Sc and Bâ is Nb or more specifically Pb(Mg Nb )O âPbTiO (âPMNâPTâ), Pb(Zn Nb )O âPbTiO (âPZNâPTâ), and Pb(Sc Nb )O âPbTiO (âPSNâPTâ). The invention also includes a transducer comprising a plurality of lead-based single crystal transducers. In one embodiment the ultrasonic probe comprising one or more piezoelectric components having surfaces that function as transmitting and/or receiving elements; and electrodes placed upon opposite surfaces of the elements, and wherein each lead based piezoelectric component as described above. In addition, the invention includes improved materials for reduced spurious modes.

US Patent:

6532819, Mar 18, 2003

Filed:

Feb 29, 2000

Appl. No.:

09/515346

Inventors:

Jie Chen - North Andover MA 01845
Rajesh Panda - Nashua NH 03060
Patrick G Rafter - Windham NH 03087
Turuvekere R Gururaja - Discovery Bay, HK

International Classification:

G01N 2900

US Classification:

73606

Abstract:

The present disclosure relates to an imaging system for harmonic imaging of an object in a medium. The system comprises a transducer formed of a single crystal of a piezoelectric material, a transmitter for transmitting waves into the medium, a receiver for receiving echoed waves from the medium, and a control system electrically connected to the transmitter and the receiver which is used control the operation of the transmitter and interpret signals received by the receiver. In a preferred embodiment, the single crystal of piezoelectric material comprises a PMN-PT material or a PZN-PT material. Through use of this material, -6 dB bandwidths of at least approximately 95% are obtainable.

US Patent:

7288538, Oct 30, 2007

Filed:

Aug 23, 2004

Appl. No.:

10/924180

Inventors:

Chengde Wu - Pearland TX, US
Daxin Gao - Houston TX, US
Ronald Biediger - Houston TX, US
Jie Chen - Houston TX, US
Robert V. Market - Pearland TX, US

Assignee:

Encysive Pharmaceuticals, Inc. - Houston TX

International Classification:

A61K 31/5375
A61K 31/4523
A61K 31/4025
A61K 31/381
C07D 413/10
C07D 409/10

US Classification:

51421019, 5142315, 514326, 514422, 514444, 544146, 546213, 548527, 548950, 549 59, 549 60

Abstract:

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.

US Patent:

7579340, Aug 25, 2009

Filed:

Aug 22, 2007

Appl. No.:

11/895069

Inventors:

Ronald Biediger - Houston TX, US
Jie Chen - Houston TX, US
Daxin Gao - Houston TX, US
Robert Market - Pearlman TX, US
Chengde Wu - Pearland TX, US

Assignee:

Pfizer Inc - New York NY

International Classification:

A61K 31/5375
A61K 31/4523
A61K 31/4025
A61K 31/381
C07D 413/10
C07D 409/10

US Classification:

51421019, 5142315, 514326, 514422, 514444, 544146, 546213, 548527, 548950, 549 59, 549 60

Abstract:

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.

US Patent:

20080188528, Aug 7, 2008

Filed:

Dec 21, 2007

Appl. No.:

12/004956

Inventors:

Ronald J. Biediger - Houston TX, US
Huong M. Bui - Pearland TX, US
Jie Chen - Houston TX, US
Kevin M. Henry - Pearland TX, US
Thomas Thrash - Houston TX, US

International Classification:

A61K 31/4439
C07D 213/02
A61K 31/44
A61K 31/381
A61K 31/34
A61P 25/00
A61P 31/00
A61P 15/08
A61P 9/00
C07D 307/34
C07D 333/02
A61K 31/19

US Classification:

514341, 546298, 514350, 514557, 562400, 5462747, 549 29, 514438, 549487, 514461

Abstract:

Provided are compounds that are modulators of C3a receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, the compounds are pyridones. In certain embodiments, provided are methods for treatment or amelioration of diseases associated with modulation of C3a receptor activity.

US Patent:

20090149638, Jun 11, 2009

Filed:

Sep 26, 2008

Appl. No.:

12/238797

Inventors:

Arthur C. Ley - Newton MA, US
Jie Chen - Sudbury MA, US

International Classification:

C07K 1/34
C12M 1/00

US Classification:

530412, 4352831

Abstract:

Described herein are novel systems and downstream protein purification (DSP) processes that provide high quality product rapidly, and on a large scale. Many of the processes enable one chromatography step to follow another chromatography step without an intermediate ultrafiltration/diafiltration (UFDF) step. These optimized processes allow for automation on the manufacture plant floor, permitting the use of a multi-cycling strategies that can utilize smaller, less expensive columns. The processes can provide considerable advantage on production efficiency, cost saving and on waste disposal.