Jie Chen

US Patent:

6381197, Apr 30, 2002

Filed:

Mar 8, 2000

Appl. No.:

09/521393

Inventors:

Bernard J Savord - Andover MA 01810
William J Ossmann - Acton MA 01720
Jie Chen - North Andover MA 01845
Michael P Anthony - Andover MA 01810
Turuvekere R Gururaja - Parkvale Drive Discovery Bay, HK
Stephen M Grenon - Hillsborough NC 27278

International Classification:

H04R 1700

US Classification:

367178

Abstract:

A micro-machined ultrasonic transducer (MUT) having aperture, elevation and apodization controlled by apparatus located on the same substrate as the transducer, or by bias voltage control applied to MUT elements, allows for an efficient and compact ultrasonic probe. The control apparatus may take the form of field effect transistors (FETs), micro-machined relays, or doped regions on the substrate, or any other apparatus that may be located on the same substrate as that of the transducer, or by bias voltage sources connected to the MUT elements.

US Patent:

6425869, Jul 30, 2002

Filed:

Jul 18, 2000

Appl. No.:

09/618350

Inventors:

Patrick G Rafter - Windham NH
Jodi Lisa Tuck Perry - Methuen MA
Jie Chen - North Andover MA

Assignee:

Koninklijke Philips Electronics, N.V. - Eindhoven

International Classification:

A61B 814

US Classification:

600458

Abstract:

A system and method for ultrasonic harmonic imaging of both tissue and tissue perfused with a contrast agent are disclosed. The ultrasonic harmonic imaging system comprises a wideband phased-array transducer, a transmitter for transmitting waves into the tissue, a receiver for receiving ultrasonic responses from the tissue, a control system electrically coupled to the transmitter and the receiver for controlling operation of the transmitter and receiver, a video processor, and a monitor. In a preferred embodiment, the transducer insonifies tissue at a fundamental frequency of less than approximately 1. 5 MHz. A method for detecting an ultrasonic harmonic response of a contrast agent may be performed by introducing at least one contrast agent into the target object, destroying the contrast agent with an ultrasonic pressure wave and measuring the harmonic response from the destroyed contrast agent. A method for detecting an ultrasonic harmonic tissue response may be performed by insonifying the tissue at a low frequency for increased uniformity in depth and using transmit apodization of a wideband phased-array transducer to improve harmonic generation in the near-field.

US Patent:

6465937, Oct 15, 2002

Filed:

Mar 8, 2000

Appl. No.:

09/521167

Inventors:

Jie Chen - North Andover MA
Rajesh Kumar Panda - Nashua NH
Turuvekere R Gururaja - Discovery Bay, HK
Heather Beck - Clemsford MA

Assignee:

Koninklijke Philips Electronics N.V. - Eindhoven

International Classification:

H01L 4104

US Classification:

310360

Abstract:

This invention is directed to a transducer comprising a lead-based single crystal wherein the crystal is diagonally oriented and has an effective coupling constant of at least 0. 70. In one embodiment, the lead-based crystal has the formula Pb(BâBâ)O âPbTiO wherein Bâ is Mg , Zn , Ni or Sc and Bâ is Nb , Ta or W. Preferably, the lead-based crystal has of the formula Pb(BâBâ)O âPbTiO where Bâ is Mg , Zn , Sc and Bâ is Nb or more specifically Pb(Mg Nb )O âPbTiO (âPMNâPTâ), Pb(Zn Nb )O âPbTiO (âPZNâPTâ), and Pb(Sc Nb )O âPbTiO (âPSNâPTâ). The invention also includes a transducer comprising a plurality of lead-based single crystal transducers. In one embodiment the ultrasonic probe comprising one or more piezoelectric components having surfaces that function as transmitting and/or receiving elements; and electrodes placed upon opposite surfaces of the elements, and wherein each lead based piezoelectric component as described above. In addition, the invention includes improved materials for reduced spurious modes.

US Patent:

6532819, Mar 18, 2003

Filed:

Feb 29, 2000

Appl. No.:

09/515346

Inventors:

Jie Chen - North Andover MA 01845
Rajesh Panda - Nashua NH 03060
Patrick G Rafter - Windham NH 03087
Turuvekere R Gururaja - Discovery Bay, HK

International Classification:

G01N 2900

US Classification:

73606

Abstract:

The present disclosure relates to an imaging system for harmonic imaging of an object in a medium. The system comprises a transducer formed of a single crystal of a piezoelectric material, a transmitter for transmitting waves into the medium, a receiver for receiving echoed waves from the medium, and a control system electrically connected to the transmitter and the receiver which is used control the operation of the transmitter and interpret signals received by the receiver. In a preferred embodiment, the single crystal of piezoelectric material comprises a PMN-PT material or a PZN-PT material. Through use of this material, -6 dB bandwidths of at least approximately 95% are obtainable.

US Patent:

6737431, May 18, 2004

Filed:

Mar 6, 2003

Appl. No.:

10/383131

Inventors:

Katherine S. Takaki - Middletown CT
Li-Qiang Sun - Glastonbury CT
Graham Johnson - Madison CT
Stephen R. Bertenshaw - Cheshire CT
Derek Denhart - Durham CT
Jie Chen - Madison CT

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31423

US Classification:

514375, 548217, 548224

Abstract:

Novel benzoxazole derivatives which have a binding affinity for the human melatonin receptor and, therefore, are useful as melatonergic agents.

US Patent:

6831080, Dec 14, 2004

Filed:

May 31, 2002

Appl. No.:

10/160582

Inventors:

Yong-Jin Wu - Madison CT
Jie Chen - Madison CT
Huan He - Wallingford CT
Alexandre LHeureux - Longueuil, CA
Pierre Dextraze - Laprairie, CA
Jean-Paul Daris - St. Hubert, CA
Gene G. Kinney - Collegeville PA
Steven I. Dworetzky - Middlefield CT
Piyasena Hewawasam - Middletown CT

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07C23720

US Classification:

5142305, 544168, 544146, 544105, 544335, 544336, 544393, 546337, 546175, 546265, 5142378, 5142315, 514357, 514311, 514256, 514332, 5142521, 51425503

Abstract:

There is provided novel cinnamide derivatives of Formula I: wherein R is C alkyl or trifluoromethyl; R is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, chromanyl, indanyl, biphenylyl, phenyl and substituted phenyl in which said substituted phenyl is substituted with one or two substituents each independently selected-from the group consisting of halogen, C alkyl, C alkoxy, trifluoromethyl, trifluoromethoxy and nitro; R and R are each independently selected from the group consisting of hydrogen, C alkyl, and halogen; R is selected from the group consisting of di(C alkyl)amino, trifluoromethoxy and optionally substituted morpholin-4-yl, pyridinyl, pyrimidinyl, piperazinyl, and pyrazinyl with one or two substituents in which said substituent is independently selected from the group consisting of C alkyl, aminomethyl, hydroxymethyl, chloro or fluoro; R is hydrogen, chloro or fluoro; or R and R taken together are âCH CHâCH CHâ or âX(CH ) Yâ in which X and Y are each independently selected from the group consisting of CH , (CH ) N(R )â and O, wherein m is 1 or 2; n is 0 or 1; and R , R , and R are each independently selected from hydrogen, chloro and fluoro; and R is selected from the group consisting of hydrogen, C alkyl, hydroxyethyl, C alkoxyethyl, cyclopropylmethyl, âCO (C alkyl), and âCH CH NR R in which R and R are each independently hydrogen or C alkyl, which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.

US Patent:

6900210, May 31, 2005

Filed:

Nov 21, 2003

Appl. No.:

10/719538

Inventors:

Yong-Jin Wu - Madison CT, US
Li-Qiang Sun - Glastonbury CT, US
Jie Chen - Madison CT, US
Huan He - Wallingford CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D213/643
C07D239/34
C07D241/18
A61K031/4412
A61K031/513

US Classification:

5142521, 514274, 514314, 514336, 514351, 544316, 544408, 546175, 5462804, 5462814, 5462834, 5462847, 546300

Abstract:

The present invention provides novel heterocyclic amides and related derivatives having the general Formula I wherein R, R, R, R, R, R, A, B and Z are as defined in the specification, or a nontoxic pharmaceutically acceptable salt, solvate or hydrate thereof which are openers or activators of KCNQ potassium channels. The present invention also provides pharmaceutical compositions comprising said heterocyclic amides and to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine or a migraine attack, bipolar disorders, epilepsy, acute and chronic pain and anxiety.

US Patent:

7087609, Aug 8, 2006

Filed:

Nov 21, 2003

Appl. No.:

10/719188

Inventors:

Yong-Jin Wu - Madison CT, US
Li-Qiang Sun - Glastonbury CT, US
Jie Chen - Madison CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/496
C07D 401/04
C07D 401/14
C07D 409/14

US Classification:

51425301, 51425306, 544360, 544363, 544364

Abstract:

The present invention provides piperazinyl phenylethyl amides and related derivatives having the general Formula I.