9628 Capricorn Way, San Diego, CA 92126 • 2137494284
9341 Hillery Dr #1630, San Diego, CA 92126
10623 Dabney Dr #37, San Diego, CA 92126
Belmont, CA
San Jose, CA
2667 Orchard Ave #3, Los Angeles, CA 90007 • 3237321824
1146 W 30Th St #5, Los Angeles, CA 90007 • 2137494284
Work
Company:
Dexcom, inc - San Diego, CA
Nov 2010
Position:
Senior scientist
Education
School / High School:
University of Southern California- Los Angeles, CA
1998
Specialities:
PhD in Polymer Chemistry
Skills
Comprehensive experience in medical devi... • biodegradable polymers • polymer drug delivery systems. Han... • in vitro and in vivo evaluation of formu... • drug polymer conjugation. Polymer ch... • glass transition temperature • tensile property • viscosity • etc. Comprehensive knowledge and exp... • such as GPC • NMR • HPLC • UV/Vis • DSC • TLC • flash chromatography. Excellent comm... • interpersonal and organizational skills.
Us Patents
Bis-(Alpha-Amino)-Diol-Diester-Containing Poly (Ester Amide) And Poly (Ester Urethane) Compositions And Methods Of Use
Zaza D. Gomurashvili - La Jolla CA, US Jonathan Macferran Hughes - Carlsbad CA, US Jie Da - San Diego CA, US Huashi Zhang - San Diego CA, US
International Classification:
A61F 2/82 C08G 65/26 A61P 9/00 A61K 47/32
US Classification:
424426, 525410, 5147725
Abstract:
The present invention provides biodegradable, biocompatible bis-(α-amino acyl)-diol-diester-containing poly(ester amide) (PEA) and poly(ester urethane) (PEUR) co-polymer compositions with mechanical properties that can be readily tailored by selection of various combinations and proportions of the building blocks of the co-polymers. The compositions are suitable for use in production of drug-releasing biodegradable particles and implantable surgical devices, such as stents and internal fixation devices. The co-polymer compositions, particles and surgical devices biodegrade in vivo by enzymatic action to release bioactive agents in a controlled manner over time as well as biocompatible breakdown products, including one to multiple different amino acids.
Bis-(Alpha-Amino)-Diol-Diester-Containing Poly (Ester Amide) And Poly (Ester Urethane) Compositions And Methods Of Use
Jonathan Macferran HUGHES - Carlsbad CA, US Jie DA - San Diego CA, US Huashi ZHANG - San Diego CA, US
Assignee:
MEDIVAS, LLC - San Diego CA
International Classification:
C08L 77/12
US Classification:
5147723, 528337
Abstract:
The present invention provides biodegradable, biocompatible bis-(α-amino acyl)-diol-diester-containing poly(ester amide) (PEA) and poly(ester urethane) (PEUR) co-polymer compositions with mechanical properties that can be readily tailored by selection of various combinations and proportions of the building blocks of the co-polymers. The compositions are suitable for use in production of drug-releasing biodegradable particles and implantable surgical devices, such as stents and internal fixation devices. The co-polymer compositions, particles and surgical devices biodegrade in vivo by enzymatic action to release bioactive agents in a controlled manner over time as well as biocompatible breakdown products, including one to multiple different amino acids.
Dexcom - Greater San Diego Area Nov 2010 - Jan 2013
Senior Scientist
MediVas, LLC - Greater San Diego Area Jun 2003 - Nov 2007
Manager of Polymer Research
Education:
University of Southern California 1998 - 2003
Ph.D, Polymer Chemistry
Fudan University 1993 - 1997
B.S, Chemistry
Skills:
Polymer Biomaterials Continuous Glucose Monitoring Drug Delivery Medical Devices Formulation Polymers Sensors Materials R&D Hplc Biotechnology Technology Transfer Chemistry Nmr Organic Synthesis Start Ups Design of Experiments
Dexcom, Inc San Diego, CA Nov 2010 to Jan 2013 Senior ScientistMediVas, LLC San Diego, CA Jun 2003 to Nov 2007 Manager of Polymer Research
Education:
University of Southern California Los Angeles, CA 1998 to 2003 PhD in Polymer Chemistry
Skills:
Comprehensive experience in medical device product design and development within polymer material. Expertise in Continuous Glucose Monitoring (CGM) sensor technology and Intravenous Blood Glucose (IVBG) sensor technology. Profound knowledge of polymer materials; biomaterials, biodegradable polymers, polymer drug delivery systems. Hands on experience in polymer drug delivery systems formulation, in vitro and in vivo evaluation of formulated materials. Synthesis and fabrication of nano and micro-particles for polymer drug delivery system. Hands-on experience in monomer and polymer synthesis and scale up, drug polymer conjugation. Polymer characterization techniques including molecular weight, glass transition temperature, tensile property, viscosity, etc. Comprehensive knowledge and experience in fluorinated amphiphilic polymer. Polycondensation by active ester or interfacial polycondensation polymerization. Uses advanced analysis tools and methods to solve complex technical problems, such as GPC, NMR, HPLC, UV/Vis, DSC, TLC, flash chromatography. Excellent communication, interpersonal and organizational skills.