Jie Yu Li

US Patent:

20080214569, Sep 4, 2008

Filed:

Feb 8, 2007

Appl. No.:

11/703401

Inventors:

Zhengping Zhuang - Bethesda MD, US
Edward H. Oldfield - Philmont VA, US
Deric M. Park - Pittsburgh PA, US
Irina Lubensky - Potomac MD, US
Jie Li - Gaithersburg MD, US
John S. Kovach - East Setauket NY, US

International Classification:

A61K 31/496
C12Q 1/02
G01N 33/50
A61P 35/00

US Classification:

51425501, 435 29, 436 86

Abstract:

This invention provides a method of treating a patient suffering from a tumor overexpressing N—CoR comprising administering to the patient a phosphatase ligand, alone or in combination with a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N—CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N—CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N—CoR. This invention also provides a method of assessing the likelihood that a patient is suffering from a tumor overexpressing N—CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N—CoR has suffered a recurrence of a tumor overexpressing N—CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme.