Jie L Li

US Patent:

6548499, Apr 15, 2003

Filed:

Oct 20, 2000

Appl. No.:

09/622423

Inventors:

Kenneth G. Carson - Needham MA
David Thomas Connor - Ann Arbor MI
Jie Jack Li - Ann Arbor MI
Joseph Edwin Low - Brighton MI
Jay R. Luly - Wellesley MA
Steven Robert Miller - Ann Arbor MI
Bruce David Roth - Plymouth MI
Bharat Kalidas Trivedi - Farmington Hills MI

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31495

US Classification:

514249, 544353, 544356

Abstract:

Quinoxaline compounds are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as interleukin-8 (IL-8) receptor antagonists and can be used in the treatment of a chemokine-mediated disease wherein the chemokine binds to an IL-8a (CXCR1) or b (CXCR2) receptor such as a chemokine-mediated disease selected from psoriasis, or atopic distress syndrome, arthritis, inflammatory bowel disease, Crohns disease, ulcerative colitis, gastric ulcer, septic shock, endotoxic shock, gram-negative sepsis, toxic shock syndrome, stroke, cardiac and renal reperfusion injury, glomerulo-nephritis, or thrombosis, Alzheimers disease, graft versus host reaction, allograft rejections, or allergic diseases.

US Patent:

8586030, Nov 19, 2013

Filed:

Mar 8, 2013

Appl. No.:

13/791313

Inventors:

Niven Rajin Narain - Cambridge MA, US
Jie Li - Miami FL, US
Kathryn J. Russell - New York NY, US
Indushekhar Persaud - Homestead FL, US

Assignee:

University of Miami - Miami FL

International Classification:

A61K 38/43

US Classification:

424 941

Abstract:

Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.

US Patent:

20090318527, Dec 24, 2009

Filed:

Feb 11, 2009

Appl. No.:

12/369659

Inventors:

Howard Sard - Arlington MA, US
Yiliang Zhang - Lowell MA, US
Jie Li - Baltimore MD, US
Louis Shuster - Brookline MA, US
Bryan Roth - Durham NC, US
Niels Jensen - Carrboro NC, US

International Classification:

A61K 31/404
C07D 209/14

US Classification:

514415, 548491

Abstract:

Novel indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.

US Patent:

20100048483, Feb 25, 2010

Filed:

Aug 21, 2009

Appl. No.:

12/545406

Inventors:

Guohan Yang - Mansfield MA, US
Ton T. Hai - Round Lake IL, US
Bennett Melnick - Chicago IL, US
Paul Sanders - Greendale WI, US
Cong Jiang - Gurnee IL, US
Catherine Quinn - Mundelein IL, US
Jie Li - Cary NC, US
Arounaguiry Ambroise - Cary NC, US
Larry R. Brown - Newton MA, US

Assignee:

BAXTER HEALTHCARE S.A. - Glattpark (Opfikon)
BAXTER INTERNATIONAL INC. - Deerfield IL

International Classification:

A61K 38/16
C07D 207/46
C08F 8/00
C08B 37/00
C07H 5/04
C08B 37/08
C08B 37/10
C08B 37/02
C07K 2/00
C07K 14/00
C07K 14/745
C07K 14/505
C07K 14/755
C12N 9/48
A61K 38/02
C07C 69/63
C07C 69/66
A61P 43/00

US Classification:

514 12, 548542, 525 55, 5361231, 536 187, 536102, 536103, 536 54, 536 21, 536 20, 536112, 530300, 530350, 530380, 530381, 530397, 530383, 435212, 514 2, 560226, 560186

Abstract:

The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

US Patent:

20110144090, Jun 16, 2011

Filed:

Aug 10, 2010

Appl. No.:

12/853782

Inventors:

Amy Elder - Arlington MA, US
Geraldine Harriman - Charlestown RI, US
Silvana Leit - Kirkland, CA
Jie Li - Melrose MA, US
Howard Sard - Arlington MA, US
Yiliang Zhang - Stoneham MA, US
Doug Wilson - Ayer MA, US

International Classification:

A61K 31/553
C07D 209/14
C07D 401/12
C07D 409/12
C07D 409/10
C07D 405/10
C07D 401/10
C07D 409/06
C07D 401/06
C07D 413/06
C07D 403/06
A61K 31/4045
A61K 31/4439
A61K 31/5377
A61K 31/496
A61K 31/4184
A61P 3/10
A61P 25/22
A61P 25/24
A61P 25/00
A61P 25/18
A61P 3/04

US Classification:

51421115, 548504, 5462774, 548467, 548466, 544144, 548468, 540544, 514415, 514339, 514414, 5142352, 51425409, 514394

Abstract:

Indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.

US Patent:

20130267146, Oct 10, 2013

Filed:

Mar 8, 2013

Appl. No.:

13/790692

Inventors:

Michael Moskal - Pottstown PA, US
Jie Li - Allentown PA, US
Leena Vadaketh - Doylestown PA, US

Assignee:

Crayola LLC - Easton PA

International Classification:

A63H 33/00
C08L 29/04

US Classification:

446490, 524557

Abstract:

The present invention relates to moldable sand compositions, methods for making the moldable sand compositions, and methods for using the moldable sand compositions. In a particular embodiment, the moldable sand composition comprises between about 70% to about 95% sand, between about 5% to about 30% water, a polar polymeric resin, a crosslinking agent, and a humectant. In an exemplary embodiment, the composition contains no oils, waxes, glycols, or rubbers. The composition is capable of becoming hardened over time in order to maintain the achieved shape, and can be re-wetted and molded again after becoming hardened.

US Patent:

20140023627, Jan 23, 2014

Filed:

Sep 19, 2013

Appl. No.:

14/031706

Inventors:

Niven Rajin Narain - Cambridge MA, US
Jie Li - Miami FL, US
Kathryn J. Russell - New York NY, US
Indushekhar Persaud - Homestead FL, US

Assignee:

University of Miami - Miami FL

International Classification:

A61K 9/00
A61K 45/06
A61K 31/122

US Classification:

424 941, 514690

Abstract:

Topical formulations of CoQ10 reduce the rate of tumor growth in an animcal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.

US Patent:

20220298475, Sep 22, 2022

Filed:

Jun 3, 2020

Appl. No.:

17/616050

Inventors:

- La Jolla CA, US
Zilei Liu - San Diego CA, US
Jie Li - San Diego CA, US
John Teijaro - San Diego CA, US

International Classification:

C12N 5/078
C12N 9/10

Abstract:

The present disclosure provides compositions and methods for monitoring cell to cell (“cell-cell”) interactions in vitro, ex vivo, and in vivo. In some embodiments, the present disclosure provides for the use of these compositions and methods (i) to identify and enrich for tumor-specific antigen (TSA) reactive T cells from tumor infiltrating lymphocytes (TILs) or circulating T cells; (ii) to identify and enrich for T cells that recognize autoantigens in a particular autoimmune disease, and/or (iii) to identify and enrich for antigen specific regulatory T cells that have the potential to be exploited to treat autoimmune disease. In some embodiments, the present disclosure also provides for methods of treating diseases, e.g., cancer with such TSA reactive T cells isolated via the present methods.