Jie Li

US Patent:

20220298475, Sep 22, 2022

Filed:

Jun 3, 2020

Appl. No.:

17/616050

Inventors:

- La Jolla CA, US
Zilei Liu - San Diego CA, US
Jie Li - San Diego CA, US
John Teijaro - San Diego CA, US

International Classification:

C12N 5/078
C12N 9/10

Abstract:

The present disclosure provides compositions and methods for monitoring cell to cell (“cell-cell”) interactions in vitro, ex vivo, and in vivo. In some embodiments, the present disclosure provides for the use of these compositions and methods (i) to identify and enrich for tumor-specific antigen (TSA) reactive T cells from tumor infiltrating lymphocytes (TILs) or circulating T cells; (ii) to identify and enrich for T cells that recognize autoantigens in a particular autoimmune disease, and/or (iii) to identify and enrich for antigen specific regulatory T cells that have the potential to be exploited to treat autoimmune disease. In some embodiments, the present disclosure also provides for methods of treating diseases, e.g., cancer with such TSA reactive T cells isolated via the present methods.

US Patent:

20200010795, Jan 9, 2020

Filed:

Feb 1, 2018

Appl. No.:

16/482497

Inventors:

- La Jolla CA, US
Jie Li - San Diego CA, US
Yiran Zhou - San Diego CA, US
Mingkuan Chen - San Diego CA, US

International Classification:

C12N 5/00
C12N 5/0783
C12N 5/0784
C07K 16/28
C07K 16/32
A61K 47/68
C12N 9/10
A61K 47/69
A61K 47/54
A61P 35/00

Abstract:

Provided herein are engineered cells, comprising: a chemical or biological moiety covalently bound to a cell surface glycan, wherein the chemical or biological moiety is selected from the group consisting of small molecule, polynucleotide, polypeptide, and antibody. Also provided are compositions comprising these engineered cells and methods of making and using the same.

US Patent:

20190314964, Oct 17, 2019

Filed:

Apr 3, 2019

Appl. No.:

16/374384

Inventors:

- Kenosha WI, US
Nathan J. Lee - Escondido CA, US
John L. Reynertson - Geneva IL, US
Stephen M. Bauer - Aurora IL, US
Jie Li - Rancho Santa Margarita CA, US

Assignee:

Snap-on Incorporated - Kenosha WI

International Classification:

B25B 23/147
B60B 29/00

Abstract:

The present invention relates to torque application tools, such as an electronic torque screwdriver, with a multiple axis gyroscope (such as a 3-axis gyroscope or other type of gyroscope) and torque sensor that allows for simultaneous or sequential measurement of torque and angle around the axis of the tool. Targets for torque and angle measurements may be used to create algorithms to detect breakaway torque, residual torque, or to perform error proofing to ensure unique fasteners are tightened.

US Patent:

20160024587, Jan 28, 2016

Filed:

Mar 10, 2014

Appl. No.:

14/774212

Inventors:

Jianwei CHE - San Diego CA, US
Jennifer HARRIS - San Diego CA, US
Hsin-I HSIEH - , US
Jie LI - San Diego CA, US
Jun LIU - San Diego CA, US
Nicholas NG - San Diego CA, US

International Classification:

C12Q 1/68
A61K 31/497

Abstract:

The invention provides methods of monitoring differential gene expression of biomarkers to determine patient sensitivity to Wnt inhibitor, methods of determining the sensitivity of a cell to an Wnt inhibitor by measuring biomarkers, methods of screening for candidate Wnt inhibitor, Wnt inhibitor for use in head and neck squamous cell carcinoma.