Jie Hua Li

US Patent:

6548499, Apr 15, 2003

Filed:

Oct 20, 2000

Appl. No.:

09/622423

Inventors:

Kenneth G. Carson - Needham MA
David Thomas Connor - Ann Arbor MI
Jie Jack Li - Ann Arbor MI
Joseph Edwin Low - Brighton MI
Jay R. Luly - Wellesley MA
Steven Robert Miller - Ann Arbor MI
Bruce David Roth - Plymouth MI
Bharat Kalidas Trivedi - Farmington Hills MI

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 31495

US Classification:

514249, 544353, 544356

Abstract:

Quinoxaline compounds are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as interleukin-8 (IL-8) receptor antagonists and can be used in the treatment of a chemokine-mediated disease wherein the chemokine binds to an IL-8a (CXCR1) or b (CXCR2) receptor such as a chemokine-mediated disease selected from psoriasis, or atopic distress syndrome, arthritis, inflammatory bowel disease, Crohns disease, ulcerative colitis, gastric ulcer, septic shock, endotoxic shock, gram-negative sepsis, toxic shock syndrome, stroke, cardiac and renal reperfusion injury, glomerulo-nephritis, or thrombosis, Alzheimers disease, graft versus host reaction, allograft rejections, or allergic diseases.

US Patent:

8586030, Nov 19, 2013

Filed:

Mar 8, 2013

Appl. No.:

13/791313

Inventors:

Niven Rajin Narain - Cambridge MA, US
Jie Li - Miami FL, US
Kathryn J. Russell - New York NY, US
Indushekhar Persaud - Homestead FL, US

Assignee:

University of Miami - Miami FL

International Classification:

A61K 38/43

US Classification:

424 941

Abstract:

Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.

US Patent:

20090318527, Dec 24, 2009

Filed:

Feb 11, 2009

Appl. No.:

12/369659

Inventors:

Howard Sard - Arlington MA, US
Yiliang Zhang - Lowell MA, US
Jie Li - Baltimore MD, US
Louis Shuster - Brookline MA, US
Bryan Roth - Durham NC, US
Niels Jensen - Carrboro NC, US

International Classification:

A61K 31/404
C07D 209/14

US Classification:

514415, 548491

Abstract:

Novel indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.

US Patent:

20100048483, Feb 25, 2010

Filed:

Aug 21, 2009

Appl. No.:

12/545406

Inventors:

Guohan Yang - Mansfield MA, US
Ton T. Hai - Round Lake IL, US
Bennett Melnick - Chicago IL, US
Paul Sanders - Greendale WI, US
Cong Jiang - Gurnee IL, US
Catherine Quinn - Mundelein IL, US
Jie Li - Cary NC, US
Arounaguiry Ambroise - Cary NC, US
Larry R. Brown - Newton MA, US

Assignee:

BAXTER HEALTHCARE S.A. - Glattpark (Opfikon)
BAXTER INTERNATIONAL INC. - Deerfield IL

International Classification:

A61K 38/16
C07D 207/46
C08F 8/00
C08B 37/00
C07H 5/04
C08B 37/08
C08B 37/10
C08B 37/02
C07K 2/00
C07K 14/00
C07K 14/745
C07K 14/505
C07K 14/755
C12N 9/48
A61K 38/02
C07C 69/63
C07C 69/66
A61P 43/00

US Classification:

514 12, 548542, 525 55, 5361231, 536 187, 536102, 536103, 536 54, 536 21, 536 20, 536112, 530300, 530350, 530380, 530381, 530397, 530383, 435212, 514 2, 560226, 560186

Abstract:

The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.

US Patent:

20110144090, Jun 16, 2011

Filed:

Aug 10, 2010

Appl. No.:

12/853782

Inventors:

Amy Elder - Arlington MA, US
Geraldine Harriman - Charlestown RI, US
Silvana Leit - Kirkland, CA
Jie Li - Melrose MA, US
Howard Sard - Arlington MA, US
Yiliang Zhang - Stoneham MA, US
Doug Wilson - Ayer MA, US

International Classification:

A61K 31/553
C07D 209/14
C07D 401/12
C07D 409/12
C07D 409/10
C07D 405/10
C07D 401/10
C07D 409/06
C07D 401/06
C07D 413/06
C07D 403/06
A61K 31/4045
A61K 31/4439
A61K 31/5377
A61K 31/496
A61K 31/4184
A61P 3/10
A61P 25/22
A61P 25/24
A61P 25/00
A61P 25/18
A61P 3/04

US Classification:

51421115, 548504, 5462774, 548467, 548466, 544144, 548468, 540544, 514415, 514339, 514414, 5142352, 51425409, 514394

Abstract:

Indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.

US Patent:

20140023627, Jan 23, 2014

Filed:

Sep 19, 2013

Appl. No.:

14/031706

Inventors:

Niven Rajin Narain - Cambridge MA, US
Jie Li - Miami FL, US
Kathryn J. Russell - New York NY, US
Indushekhar Persaud - Homestead FL, US

Assignee:

University of Miami - Miami FL

International Classification:

A61K 9/00
A61K 45/06
A61K 31/122

US Classification:

424 941, 514690

Abstract:

Topical formulations of CoQ10 reduce the rate of tumor growth in an animcal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.

US Patent:

20220300764, Sep 22, 2022

Filed:

May 18, 2021

Appl. No.:

17/323656

Inventors:

- Los Altos CA, US
Simon A.I. Stent - Cambridge MA, US
John H. Gideon - Howell MI, US
Jie Li - Los Altos CA, US

International Classification:

G06K 9/62
G06K 9/32
G06K 9/34
G06N 3/04

Abstract:

Systems and methods for training a model are described herein. In one example, a system for training the model includes a processor and a memory in communication with the processor having a training module. The training module has instructions that cause the processor to determine a contrastive loss using a self-supervised contrastive loss function, adjust, based on the contrastive loss, model weights a visual backbone that generated feature maps and/or a textual backbone that generated feature vectors. The training module also has instructions that cause the processor to determine a localized loss using a supervised loss function that compares an image-caption attention map with visual identifiers and adjust, based on the localized loss, the model weights the visual backbone and/or the textual backbone.

US Patent:

20210128453, May 6, 2021

Filed:

Jun 12, 2020

Appl. No.:

16/900162

Inventors:

- Miami FL, US
Niven Rajin Narain - Cambridge MA, US
Jie Li - Miami FL, US
Kathryn J. Russell - New York NY, US
Karrune V. Woan - Gainesville FL, US
Indushekhar Persaud - Homestead FL, US

Assignee:

University of Miami - Miami FL

International Classification:

A61K 9/00
A61K 47/24
A61K 9/06
A61K 36/53
A61K 31/351
A61K 31/122
A61K 45/06

Abstract:

Topical formulations of CoQ10 reduce the rate of tumor growth in an animcal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing animals with a topical formulation of CoQ10 was shown to dramatically reduce the rate of tumor growth in the animals.