Jie Yun Wu

US Patent:

6703514, Mar 9, 2004

Filed:

May 13, 2003

Appl. No.:

10/437768

Inventors:

Jie Wu - Ridgewood NJ
Zhen Yang - Ridgewood NJ
Reza Fathi - Hohokus NJ
Qiang Zhu - Ridgewood NJ
Lisha Wang - Ridgewood NJ

Assignee:

Vivo Quest, Inc. - Valley Cottage NY

International Classification:

C07D31102

US Classification:

549284, 549285

Abstract:

4-thio substituted coumarin derivatives and coumarin dimers are provided, as well as processes for their preparation. A synthetic process for the preparation of 4-thio substituted coumarin derivatives is provided using mild reaction conditions, which maintains a high substituent tolerance and is appropriate for use in solid phase syntheses for producing a library of 4-thio substituted coumarin derivatives for biological screening.

US Patent:

7148253, Dec 12, 2006

Filed:

Jan 6, 2004

Appl. No.:

10/752654

Inventors:

Jie Wu - Ridgewood NJ, US
Zhen Yang - Ridgewood NJ, US
Reza Fathi - Hohokus NJ, US
Qiang Zhu - Ridgewood NJ, US

Assignee:

XTL Biopharmaceuticals Ltd. - Rehovet

International Classification:

A61K 31/35

US Classification:

514456, 514457, 549284, 549285

Abstract:

4-Thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers are provided, as well as processes for their preparation. The invention also provides a method and composition for the treatment of hepatitis C virus (HCV) by adiministering 4-thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers.

US Patent:

8476274, Jul 2, 2013

Filed:

Oct 18, 2012

Appl. No.:

13/655176

Inventors:

Li Dong - Lawrenceville NJ, US
Christopher W. Boyce - Flemington NJ, US
Manuel de Lera Ruiz - Branchburg NJ, US
Salem Fevrier - Cranford NJ, US
Jie Wu - Scotch Plains NJ, US
Junying Zheng - New Providence NJ, US
Younong Yu - East Brunswick NJ, US
Jianhua Chao - San Diego CA, US
Walter S. Won - Alpine NJ, US
Ashwin U. Rao - Morganville NJ, US
Rongze Kuang - Green Brook NJ, US
Pauline C. Ting - New Providence NJ, US
Xianhai Huang - Warren NJ, US
Ning Shao - Clark NJ, US
Anandan Palani - Bridgewater NJ, US
Michael Y. Berlin - Flemington NJ, US
Robert G. Aslanian - Rockaway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/501
A61K 31/497
A61K 31/506
A61K 31/4439
A61K 31/427
A61K 31/423
C07D 235/02
C07D 405/02
C07D 409/02
C07D 413/02
C07D 263/52

US Classification:

51425206, 51425505, 514256, 514278, 514365, 514375, 544230, 546 15, 548147, 548216, 548247

Abstract:

In its many embodiments, the present invention provides a novel class of biaryl spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.

US Patent:

8569312, Oct 29, 2013

Filed:

Apr 4, 2013

Appl. No.:

13/857001

Inventors:

Li Dong - Lawrenceville NJ, US
Christopher W. Boyce - Flemington NJ, US
Manuel de Lera Ruiz - Branchburg NJ, US
Salem Fevrier - Cranford NJ, US
Jie Wu - Scotch Plains NJ, US
Junying Zheng - New Providence NJ, US
Younong Yu - East Brunswick NJ, US
Jianhua Chao - San Diego CA, US
Walter S. Won - Alpine NJ, US
Ashwin U. Rao - Morganville NJ, US
Rongze Kuang - Green Brook NJ, US
Pauline C. Ting - New Providence NJ, US
Xianhai Huang - Warren NJ, US
Ning Shao - Clark NJ, US
Anandan Palani - Bridgewater NJ, US
Michael Y. Berlin - Flemington NJ, US
Robert G. Aslanian - Rockaway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

A61K 31/506
A61K 31/501
A61K 31/4439
A61K 31/497
A61K 31/4184
C07D 235/02
C07D 405/10
C07D 409/10
C07D 403/10

US Classification:

514256, 51425206, 514278, 51425505, 514393, 514378, 544230, 546 15, 5483011, 548247, 5483007

Abstract:

In its many embodiments, the present invention provides a novel class of biaryl spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.

US Patent:

20120182182, Jul 19, 2012

Filed:

Dec 14, 2011

Appl. No.:

13/325649

Inventors:

Wyatt Thomas Riley - Chesterbrook PA, US
Lalitaprasad V. Daita - San Jose CA, US
William James Morrison - San Francisco CA, US
Dominic Gerard Farmer - Los Gatos CA, US
Jie Wu - San Diego CA, US

Assignee:

QUALCOMM Incorporated - San Diego CA

International Classification:

G01S 19/20

US Classification:

34235758

Abstract:

A mobile device may use one or more outlier detectors to detect likelihoods that an outlier condition exists for a satellite positioning system (SPS) position fix. In some implementations, an outlier detector may compare a computed position fix to an element of assistance data to generate an outlier likelihood. A decision to perform a recovery operation may be made based, at least in part, on a generated outlier likelihood. In some implementations, a computed reliability of the position fix may also be considered in making a recovery decision.