Jie Wu

US Patent:

6703514, Mar 9, 2004

Filed:

May 13, 2003

Appl. No.:

10/437768

Inventors:

Jie Wu - Ridgewood NJ
Zhen Yang - Ridgewood NJ
Reza Fathi - Hohokus NJ
Qiang Zhu - Ridgewood NJ
Lisha Wang - Ridgewood NJ

Assignee:

Vivo Quest, Inc. - Valley Cottage NY

International Classification:

C07D31102

US Classification:

549284, 549285

Abstract:

4-thio substituted coumarin derivatives and coumarin dimers are provided, as well as processes for their preparation. A synthetic process for the preparation of 4-thio substituted coumarin derivatives is provided using mild reaction conditions, which maintains a high substituent tolerance and is appropriate for use in solid phase syntheses for producing a library of 4-thio substituted coumarin derivatives for biological screening.

US Patent:

7148253, Dec 12, 2006

Filed:

Jan 6, 2004

Appl. No.:

10/752654

Inventors:

Jie Wu - Ridgewood NJ, US
Zhen Yang - Ridgewood NJ, US
Reza Fathi - Hohokus NJ, US
Qiang Zhu - Ridgewood NJ, US

Assignee:

XTL Biopharmaceuticals Ltd. - Rehovet

International Classification:

A61K 31/35

US Classification:

514456, 514457, 549284, 549285

Abstract:

4-Thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers are provided, as well as processes for their preparation. The invention also provides a method and composition for the treatment of hepatitis C virus (HCV) by adiministering 4-thio substituted coumarin derivatives, 4,5-dithio substituted coumarin derivatives, and coumarin dimers.