Jill M Hemish

US Patent:

20090162848, Jun 25, 2009

Filed:

Aug 7, 2008

Appl. No.:

12/228148

Inventors:

Naoki Nakaya - Rockville MD, US
Jill Hemish - Cold Spring Harbor NY, US
Grigori Enikolopov - Cold Spring Harbor NY, US

Assignee:

COLD SPRING HARBOR LABORATORY - Cold Spring Harbor NY

International Classification:

C12Q 1/68
C12N 15/11
C12N 15/00
A01K 67/027
C12N 5/06
C12N 15/82
C12Q 1/02

US Classification:

435 6, 536 235, 4353201, 800 13, 800 14, 435354, 435455, 435 29

Abstract:

The invention provides for novel noxin polypeptides and nucleic acids from humans, rats, and mice and to related compositions and uses. The invention also provides for the creation of non-human, transgenic mammals which have, incorporated in their genome, DNA that includes a sequence of a mammalian noxin gene that does not produce noxin polypeptides, i.e. a noxin knockout mouse.The invention also provides for methods for protecting a cell from stress damage by enhancing the expression noxin, methods for decreasing cell death by enhancing the expression of noxin, methods for inducing cell death by decreasing noxin activity, methods for inducing cell cycle arrest by increasing noxin, and methods for preventing cell cycle arrest by inhibiting noxin activity.