Jim G Stone

US Patent:

20130060017, Mar 7, 2013

Filed:

Jul 16, 2012

Appl. No.:

13/550055

Inventors:

Dennis ESHIMA - Phoenix AZ, US
Mehmet HUSNU - Phoenix AZ, US
Jim STONE - Alpharetta GA, US
Brian C. KELLEY - Pataskala OH, US

Assignee:

CARDINAL HEALTH 414, LLC - Dublin OH

International Classification:

C07H 1/00

US Classification:

536122

Abstract:

The invention relates to methods for synthesizing compounds on solid supports. The invention also relates to synthesizing labeled compounds, such as those used in the field of radiopharmaceuticals. The invention relates to methods for synthesizing halogenated radiopharmaceuticals such as fludeoxyglucose (also known as fluorodeoxyglucose or FDG).

US Patent:

20130060134, Mar 7, 2013

Filed:

Sep 7, 2012

Appl. No.:

13/606591

Inventors:

Dennis ESHIMA - Phoenix AZ, US
Mehmet HUSNU - Phoenix AZ, US
Jim STONE - Alpharetta GA, US

Assignee:

CARDINAL HEALTH 414, LLC - Dublin OH

International Classification:

G01T 1/24
A61B 6/04
A61N 5/10
G01T 1/167

US Classification:

600431, 2503361, 250394, 25037013, 600 1

Abstract:

A tumor treatment apparatus may include an array of collimated CZT detectors configured to intersect a known coordinate and measure gamma radiation activity, for example at 511 keV. A radiation delivery system may be configured to direct radiation through the known coordinate on the basis of the gamma radiation activity. A translatable and rotatable table may be configured to support a tumor host, wherein the tumor is positionable relative to the known coordinate on the basis of the gamma radiation activity emitted by the tumor and measured by the array of collimated CZT detectors. Radiation from the radiation delivery system may be delivered to the tumor at the known coordinate, and may be delivered in an intra-operative surgical environment.

US Patent:

20130102772, Apr 25, 2013

Filed:

Jul 16, 2012

Appl. No.:

13/550425

Inventors:

Dennis ESHIMA - Phoenix AZ, US
Mehmet Husnu - Phoenix AZ, US
Jim Stone - Alpharetta GA, US
Derrick Alcaide - Los Angeles CA, US
Henry Padgett - Dublin OH, US
Joseph E. Zambanini - Delaware OH, US
Thomas A. Klausing - Powell OH, US
Chad E. Bouton - Powell OH, US
Brian C. Kelley - Pataskala OH, US
Scott N. Danhof - Plain City OH, US
David A. Holley - Lancaster OH, US
Jeffrey T. Stroup - Upper Arlington OH, US
James B. Gleeson - Columbus OH, US
Eric Hassenpflug - Westerville OH, US
James A. Prescott - Columbus OH, US
Herman Benecke - Columbus OH, US
Daniel B. Garbark - Blacklick OH, US

Assignee:

CARDINAL HEALTH 414, LLC - Dublin OH

International Classification:

B01J 19/00
B65B 1/00

US Classification:

536 282, 536122, 5483275, 422159, 422119, 422110, 53473

Abstract:

Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.

US Patent:

20130018618, Jan 17, 2013

Filed:

Jul 16, 2012

Appl. No.:

13/550030

Inventors:

Dennis Eshima - Phoenix AZ, US
Mehmet Husnu - Phoenix AZ, US
Jim Stone - Alpharetta GA, US

Assignee:

CARDINAL HEALTH 414, LLC - Dublin OH

International Classification:

G06F 19/00

US Classification:

702 83

Abstract:

A method and system for performing automated quality control analysis of a plurality of radiopharmaceuticals are provided. The method includes uniquely identifying each of the plurality of radiopharmaceuticals, and identifying and implementing a tailored quality control program for each of the radiopharmaceuticals. The method further includes automatically performing a plurality of selected quality control tests for each of the radiopharmaceuticals based on the tailored quality control program, and collecting information produced by the plurality of selected quality control tests.

US Patent:

20160263545, Sep 15, 2016

Filed:

Sep 30, 2015

Appl. No.:

14/871287

Inventors:

- Dublin OH, US
MEHMET HUSNU - PHOENIX AZ, US
JIM STONE - ALPHARETTA GA, US
DERRICK ALCAIDE - LOS ANGELES CA, US
JOSEPH E. ZAMBANINI - DELAWARE OH, US
THOMAS A. KLAUSING - POWELL OH, US
CHAD E. BOUTON - POWELL OH, US
HENRY PADGETT - DUBLIN OH, US
BRIAN C. KELLEY - PATASKALA OH, US
SCOTT N. DANHOF - PLAIN CITY OH, US
DAVID A. HOLLEY - LANCASTER OH, US
JEFFREY T. STROUP - UPPER ARLINGTON OH, US
JAMES B. GLEESON - COLUMBUS OH, US
ERIC HASSENPFLUG - WESTERVILLE OH, US
JAMES A. PRESCOTT - COLUMBUS OH, US
HERMAN BENECKE - COLUMBUS OH, US
DANIEL B. GARBARK - BLACKLICK OH, US

Assignee:

CARDINAL HEALTH 414, LLC - Dublin OH

International Classification:

B01J 19/00

Abstract:

Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.