Prashant Saxena - Portland OR, US Vishal Khandelwal - Hillsboro OR, US Pei-Hsin Ho - Portland OR, US Jing C. Lin - Cupertino CA, US Mahesh A. Iyer - Fremont CA, US
A persistence-driven optimization technique is provided in which nets can be ranked based on unpredictability and likely quality of result impact. The top nets in that ranking can be routed and their parasitics extracted. A timing graph can be back-annotated with route-based delays and parasitics for the selected nets. At this point, synthesis can be run using actual route-based delays and parasitics for the selected nets, with their routes being updated incrementally as needed. In one embodiment, the nets can be re-ranked after synthesis. Finally, these routes can be preserved across the subsequent global routing of the remaining nets.
Methods For Characterizing Antibody Binding Affinity And Epitope Diversity In Food Allergy
Hugh A. Sampson - Greenwich CT, US Jing Lin - Philadelphia PA, US Ludmilla Bardina - New York NY, US
Assignee:
Mount Sinai School of Medicine of New York University - New York NY
International Classification:
C40B 30/04 C40B 40/10 C07K 7/08 C07K 14/00
US Classification:
506 9, 506 18, 530326, 530327, 530324, 530350
Abstract:
Methods for performing epitope mapping, and for characterizing the antibody binding affinity and epitope diversity of antibodies in a sample using peptide microarray are provided. In some aspects, methods are provided for the specific characterization of IgE and IgG4. Also disclosed are methods for diagnosing whether a milk-allergic individual will outgrow his or her allergy based on the characterization of the individual's milk allergen-specific IgE antibodies.
Newborn Medicine AssociatesMount Sinai Hospital Newborn Medicine 1184 5 Ave STE 341, New York, NY 10029 2122415446 (phone), 2125345207 (fax)
Education:
Medical School Wenzhou Med Coll, Wenzhou, Zhejiang, China Graduated: 1983
Languages:
English Spanish
Description:
Dr. Lin graduated from the Wenzhou Med Coll, Wenzhou, Zhejiang, China in 1983. He works in New York, NY and specializes in Neonatal-Perinatal Medicine. Dr. Lin is affiliated with Mount Sinai Medical Center.