Brian W. Budzik - King of Prussia PA, US Hilary Schenck Eidam - King of Prussia PA, US Ryan Michael Fox - King of Prussia PA, US Krista B. Goodman - King of Prussia PA, US Dimitar B. Gotchev - King of Prussia PA, US Pamela A. Haile - King of Prussia PA, US Terry Vincent Hughes - King of Prussia PA, US Ronggang Liu - King of Prussia PA, US Nathan A. Miller - King of Prussia PA, US Tamara Ann Miskowski - King of Prussia PA, US Clark A. Sehon - King of Prussia PA, US Andrew Q. Viet - King of Prussia PA, US Gren Z. Wang - King of Prussia PA, US Jing Zhang - King of Prussia PA, US
Assignee:
Glaxo Group Limited - Greenford, Middlesex
International Classification:
C07D 401/04 C07D 401/14 A61K 31/438 A61K 31/4439
US Classification:
514278, 546 18
Abstract:
The present invention relates to a compound of the following formula:.
1-6-Substituted (3R,6R)-3-(2,3-Dihydro-1H-Inden-2-Yl)-2,5-Piperazinedione Derivatives As Oxytocin Receptor Antagonists For The Treatment Of Preterm Labour, Dysmenorrhea And Endometriosis
Colin Andrew Leach - King of Prussia PA, US John Liddle - Hertfordshire, GB Simon Peace - Hertfordshire, GB Joanne Philp - Hertfordshire, GB Ian Edward David Smith - Hertfordshire, GB Lamont Roscoe Terrell - King of Prussia PA, US Jing Zhang - King of Prussia PA, US
John J. Baldwin - Gwynedd Valley PA, US David A. Claremon - Maple Glen PA, US Colin M. Tice - Amber PA, US Salvacion Cacatian - Blue Bell PA, US Lawrence W. Dillard - Yardley PA, US Alexey V. Ishchenko - Somerville MA, US Jing Yuan - Landsdale PA, US Zhenrong Xu - Horsham PA, US Gerard McGeehan - Garnet Valley PA, US Wei Zhao - Eagleville PA, US Robert D. Simpson - Wilmington DE, US Suresh B. Singh - Kendall park NJ, US Patrick T. Flaherty - Pittsburgh PA, US Lara S. Kallander - King of Prussia PA, US Colin A. Leach - King of Prussia PA, US Brian Lawhorn - King of Prussia PA, US Qing Lu - King of Prussia PA, US Lamont R. Terrell - King of Prussia PA, US Jing Zhang - King of Prussia PA, US Damiano Ghirlanda - King of Prussia PA, US Xiaoping Hou - King of Prussia PA, US Simon Semus - King of Prussia PA, US
Disclosed are compounds according to Formula I:wherein the variables are defined herein. Such compounds are can bind aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity.Also described herein are methods of antagonizing aspartic protease inhibitors in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound according to Formula I.
John J. Baldwin - Gwynedd Valley PA, US Salvacion Cacatian - Blue Bell PA, US David Claremon - Maple Glen PA, US Lawrence W. Dillard - Yardley PA, US Patrick T. Flaherty - Pittsburgh PA, US Damiamo Ghirlanda - Legnago, IT Xiaoping Hou - Pennington NJ, US Lara S. Kallander - King of Prussia PA, US Beth A. Knapp-Reed - King of Prussia PA, US Brian Lawhorn - King of Prussia PA, US Qing Lu - King of Prussia PA, US Gerard McGeehan - Garnet Valley PA, US Simon Semus - Collegeville PA, US Robert D. Simpson - Wilmington DE, US Suresh B. Singh - Kendall Park NJ, US Lamont R. Terrell - King of Prussia PA, US Colin Tice - Ambler PA, US Tritin Tran - King of Prussia PA, US Zhenrong Xu - Horsham PA, US Jing Yuan - Lansdale PA, US Jing Zhang - Waltham MA, US Wei Zhao - Eagleville PA, US
Described are compounds which bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compounds described herein in ameliorating or treating aspartic protease related disorders in a subject in need thereof.
John J. Baldwin - Gwynedd Valley PA, US Salvacion Cacatian - Blue Bell PA, US David A. Claremon - Maple Glen PA, US Lawrence W. Dillard - Yardley PA, US Patrick T. Flaherty - Pittsburgh PA, US Lanqi Jia - Horsham PA, US Gerard McGeehan - Garnet Valley PA, US Robert D. Simpson - Wilmington DE, US Suresh B. Singh - Kendall Park NJ, US Colin M. Tice - Ambler PA, US Zhenrong Xu - Horsham PA, US Jing Yuan - Lansdale PA, US Wei Zhao - Eagleville PA, US Linghang Zhuang - Chalfont PA, US Jing Zhang - Waltham MA, US
The present invention is directed to aspartic protease inhibitors. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.
Jonh J. Baldwin - Gwynedd Valley PA, US Salvacion Cacatian - Blue Bell PA, US David Claremon - Maple Glen PA, US Lawrence W. Dillard - Yardley PA, US Patrick T. Flaherty - Pittsburgh PA, US Damiano Ghirlanda - Legnago, IT Alexey V. Ishchenko - Somerville MA, US Lara S. Kallander - King of Prussia PA, US Brian Lawhorn - King of Prussia PA, US Colin A. Leach - Collegeville PA, US Qing Lu - King of Prussia PA, US Gerard McGeehan - Garnet Valley PA, US Jaclyn R. Patterson - King of Prussia PA, US Robert D. Simpson - Wilmington DE, US Suresh B. Singh - Kendall Park NJ, US Patrick Stoy - King of Prussia PA, US Lamont R. Terrell - King of Prussia PA, US Colin Tice - Ambler PA, US Zhenrong Xu - Horsham PA, US Jing Yuan - Lansdale PA, US Catherine C. K. Yuan - King of Prussia PA, US Jing Zhang - Waltham MA, US Wei Zhao - Eagleville PA, US
Disclosed are compounds of Formula (I) wherein the R, R, R, R, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
Spiroindenes And Spiroindanes As Modulators Of Chemokine Receptors
Brian W. Budzik - King of Prussia PA, US Michael Jonathan Bury - King of Prussia PA, US Minghua Gu - Collegeville PA, US Ronggang Liu - King of Prussia PA, US Feng Ren - Shanghai, CN Clark A. Sehon - King of Prussia PA, US Gren Z. Wang - King of Prussia PA, US Jing Zhang - King of Prussia PA, US
The present invention relates to a compound of the following formula:or a pharmaceutically acceptable salt thereof;where R-R, Y, m, n, and p are defined herein. Compounds and compositions of the present invention are useful the treatment of atherosclerosis.
Pyridine N-Oxide Derivatives Useful As Factor Xia Inhibitors
- Beerse, BE Boying Guo - Glenside PA, US Zhijie Liu - Paoli PA, US Jing Zhang - Wilmington DE, US Micheal D. Gaul - Apex NC, US Eugene B. Grant - Flemington NJ, US Mark J. Macielag - Gwynedd Valley PA, US Tianbao Lu - Churchville PA, US Tho V. Thieu - North Wales PA, US
International Classification:
C07D 401/14 C07D 405/14 C07D 413/14 C07D 417/14
Abstract:
The present invention is directed to pyridine N-oxide derivatives, stereoisomers, isotopologues, isotopomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing said compounds and the use of said compounds in the treatment and/or prophylaxis of thromboembolic disorders, inflammatory disorders and diseases or conditions in which plasma kallikrein activity is implicated.
Name / Title
Company / Classification
Phones & Addresses
Jing Zhang
Vesta Holdings Group Holding Companies
4264 Victory St, Burnaby, BC V5J1P7 6044308091, 6044308091
Jing Zhang Xt 66818
Broadcom Corporation Semiconductors and Related Devices
5300 California Ave, Irvine, CA 92617
Jing Zhang President
Fashion Ongoing Inc
14442 Pacific Ave, Duarte, CA 91706
Jing Zhang President
EURO SHINE INTERNATIONAL GROUP Beauty & Day Spas
19049 Colima Rd, Rowland Heights, CA 91748 19049 Colima Rd, Whittier, CA 91748 6268396488
Jing Zhang President
N & J USA INC
763 Arcadia Ave #9, Arcadia, CA 91007 17890 Castleton St, Whittier, CA 91748 1410 Blackstone Rd, Pasadena, CA 91108
Jing Zhang Manager
Sen's Spa LLC
Jing Zhang Manager
Yinong LLC
Jing Zhang Chief Executive Officer
Shine Euro International Group Physical Fitness Facility
19049 Colima Rd, Whittier, CA 91748
Medicine Doctors
Dr. Jing X Zhang, Philadelphia PA - MD (Doctor of Medicine)
Lead author Jing Zhang, who earned a Ph.D. in cognitive sciences at UC Irvine in 2023 and is now a postdoctoral research fellow at Harvard Medical School, added, Our work provides the first empirical support for dreamings active involvement in sleep-dependent emotional memory processing, suggestin