David Joseph Bartkovitz - Nutley NJ, US Qingjie Ding - Bridgewater NJ, US Bradford James Graves - Nutley NJ, US Nan Jiang - Pine Brook NJ, US Jing Zhang - Parsippany NJ, US Zhuming Zhang - Hillsborough NJ, US
David Joseph Bartkovitz - Nutley NJ, US Qingjie Ding - Bridgewater NJ, US Nan Jiang - Pine Brook NJ, US Jin-Jun Liu - Warren Township NJ, US Tina Morgan Ross - Royersford PA, US Jing Zhang - Parsippany NJ, US Zhuming Zhang - Hillsborough NJ, US
Assignee:
Hoffmann-La Roche Inc. - Nutley NJ
International Classification:
A61K 31/40 C07D 207/04
US Classification:
514423, 548530, 548537, 514408
Abstract:
There are provided compounds of the formula.
Spiroindolines As Modulators Of Chemokine Receptors
Brian W. Budzik - King of Prussia PA, US Hilary Schenck Eidam - King of Prussia PA, US Ryan Michael Fox - King of Prussia PA, US Krista B. Goodman - King of Prussia PA, US Dimitar B. Gotchev - King of Prussia PA, US Pamela A. Haile - King of Prussia PA, US Terry Vincent Hughes - King of Prussia PA, US Ronggang Liu - King of Prussia PA, US Nathan A. Miller - King of Prussia PA, US Tamara Ann Miskowski - King of Prussia PA, US Clark A. Sehon - King of Prussia PA, US Andrew Q. Viet - King of Prussia PA, US Gren Z. Wang - King of Prussia PA, US Jing Zhang - King of Prussia PA, US
Assignee:
Glaxo Group Limited - Greenford, Middlesex
International Classification:
C07D 401/04 C07D 401/14 A61K 31/438 A61K 31/4439
US Classification:
514278, 546 18
Abstract:
The present invention relates to a compound of the following formula:.
1-6-Substituted (3R,6R)-3-(2,3-Dihydro-1H-Inden-2-Yl)-2,5-Piperazinedione Derivatives As Oxytocin Receptor Antagonists For The Treatment Of Preterm Labour, Dysmenorrhea And Endometriosis
Colin Andrew Leach - King of Prussia PA, US John Liddle - Hertfordshire, GB Simon Peace - Hertfordshire, GB Joanne Philp - Hertfordshire, GB Ian Edward David Smith - Hertfordshire, GB Lamont Roscoe Terrell - King of Prussia PA, US Jing Zhang - King of Prussia PA, US
John J. Baldwin - Gwynedd Valley PA, US David A. Claremon - Maple Glen PA, US Colin M. Tice - Amber PA, US Salvacion Cacatian - Blue Bell PA, US Lawrence W. Dillard - Yardley PA, US Alexey V. Ishchenko - Somerville MA, US Jing Yuan - Landsdale PA, US Zhenrong Xu - Horsham PA, US Gerard McGeehan - Garnet Valley PA, US Wei Zhao - Eagleville PA, US Robert D. Simpson - Wilmington DE, US Suresh B. Singh - Kendall park NJ, US Patrick T. Flaherty - Pittsburgh PA, US Lara S. Kallander - King of Prussia PA, US Colin A. Leach - King of Prussia PA, US Brian Lawhorn - King of Prussia PA, US Qing Lu - King of Prussia PA, US Lamont R. Terrell - King of Prussia PA, US Jing Zhang - King of Prussia PA, US Damiano Ghirlanda - King of Prussia PA, US Xiaoping Hou - King of Prussia PA, US Simon Semus - King of Prussia PA, US
Disclosed are compounds according to Formula I:wherein the variables are defined herein. Such compounds are can bind aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity.Also described herein are methods of antagonizing aspartic protease inhibitors in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound according to Formula I.
John J. Baldwin - Gwynedd Valley PA, US Salvacion Cacatian - Blue Bell PA, US David Claremon - Maple Glen PA, US Lawrence W. Dillard - Yardley PA, US Patrick T. Flaherty - Pittsburgh PA, US Damiamo Ghirlanda - Legnago, IT Xiaoping Hou - Pennington NJ, US Lara S. Kallander - King of Prussia PA, US Beth A. Knapp-Reed - King of Prussia PA, US Brian Lawhorn - King of Prussia PA, US Qing Lu - King of Prussia PA, US Gerard McGeehan - Garnet Valley PA, US Simon Semus - Collegeville PA, US Robert D. Simpson - Wilmington DE, US Suresh B. Singh - Kendall Park NJ, US Lamont R. Terrell - King of Prussia PA, US Colin Tice - Ambler PA, US Tritin Tran - King of Prussia PA, US Zhenrong Xu - Horsham PA, US Jing Yuan - Lansdale PA, US Jing Zhang - Waltham MA, US Wei Zhao - Eagleville PA, US
Described are compounds which bind to aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also described are methods of use of the compounds described herein in ameliorating or treating aspartic protease related disorders in a subject in need thereof.
John J. Baldwin - Gwynedd Valley PA, US Salvacion Cacatian - Blue Bell PA, US David A. Claremon - Maple Glen PA, US Lawrence W. Dillard - Yardley PA, US Patrick T. Flaherty - Pittsburgh PA, US Lanqi Jia - Horsham PA, US Gerard McGeehan - Garnet Valley PA, US Robert D. Simpson - Wilmington DE, US Suresh B. Singh - Kendall Park NJ, US Colin M. Tice - Ambler PA, US Zhenrong Xu - Horsham PA, US Jing Yuan - Lansdale PA, US Wei Zhao - Eagleville PA, US Linghang Zhuang - Chalfont PA, US Jing Zhang - Waltham MA, US
The present invention is directed to aspartic protease inhibitors. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.
Isbn (Books And Publications)
Ren Min Bi Jun Heng Hui Lu Yu Zhongguo Wai Mao: Equilibrium Exchange Rate of RMB and the Foreign Trade of China
Staten Island Medical Group
1050 Clove Rd, Staten Island, NY 10301 Staten Island Physician Practice
4771 Hylan Blvd, Staten Island, NY 10312 Henry Ford Hospital
2799 W Grand Blvd, Detroit, MI 48202
nyu.edu Brooklyn, NY Mar 1973 to May 2013Beijing University of Technology
Jun 2011 to Jun 2011
Education:
Knowledge of data center architecture Sep 2012 to 2000 computing technologyNYU-poly Jan 2012 to Sep 2012 Architecture & ProtocolsNYU-poly Sep 2012 designNYU-poly Jan 2012 Communications
Nov 2011 to Dec 2011 Intern and Media Relations AssistantYoung & Perspective, Aiesec Global Project
Sep 2011 to Oct 2011 Culture Presenter and English Teaching Assistant
Education:
Columbia University in the city of New York New York, NY 2012 to 2013 Master of Arts in SociologySun Yat-sen University Guangzhou, PRC. 2008 to 2012 Bachelor of Management in Event Management
Skills:
Microsoft Office, Java, Basic, Visual Basic, MindManager, SPSS, Stata, Photoshop
Dec 2011 to Present ConsultantLehman Brothers Holdings Inc Jersey City, NJ Jun 2011 to Dec 2011 Financial Service InternBarnes Financial Services, LLC New York, NY Jan 2011 to May 2011 Financial Service InternErnst & Young, LLP New York, NY Jun 2010 to Aug 2010 Financial Tax InternTaishan Investment AG Albany, NY Jun 2009 to May 2010 Venture Capital Extern
Education:
Baruch College, Zicklin School of Business New York, NY Sep 2010 to Dec 2011 Master of Science in TaxationUniversity at Albany, State University of New York Albany, NY Sep 2007 to May 2010 Bachelor of Science in Accounting
Lead author Jing Zhang, who earned a Ph.D. in cognitive sciences at UC Irvine in 2023 and is now a postdoctoral research fellow at Harvard Medical School, added, Our work provides the first empirical support for dreamings active involvement in sleep-dependent emotional memory processing, suggestin