Jinhua Wang

US Patent:

20230058545, Feb 23, 2023

Filed:

Oct 7, 2020

Appl. No.:

17/767413

Inventors:

- Boston MA, US
Nathanael S Gay - Stanford CA, US
Sara Jean Buhriage - Somerville MA, US
Guang Yang - Natick MA, US
Jinhua Wang - Winchester MA, US
Li Tan - Pudong, Shanghai, CN

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

C07D 487/04
C07D 471/04
C07D 403/10

Abstract:

The present disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., HCK, BTK, LYN, BLK, FRK) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating diseases (e.g., proliferative diseases) in a subject in need thereof).