Joan G Weinstein

US Patent:

20090264377, Oct 22, 2009

Filed:

Oct 21, 2008

Appl. No.:

12/288599

Inventors:

Linda Saxe Einbond - Crestwood NY, US
Morando Soffritti - Bologna, IT
Kyle Louis Kolaja - San Mateo CA, US
Richard John Brennan - San Jose CA, US
I. Bernard Weinstein - New York NY, US
Joan Weinstein - New York NY, US
Tamara Weinstein - Decatur GA, US
Claudia Weinstein - New York City NY, US
Matthew Weinstein - Brooklyn NY, US

International Classification:

A61K 31/7048
A61P 35/00
A61K 31/366
A61K 31/4418
A61K 31/40
A61K 31/404
A61K 31/337

US Classification:

514 26, 514460, 514277, 514423, 514419, 514449

Abstract:

A method is provided for treating, preventing or ameliorating neoplasia in a subject. This method includes administering to the subject an amount of actein or an amount of an extract of black cohosh that contains a triterpene glycoside, which amount of the actein or black cohosh is effective to treat, prevent or ameliorate the neoplasia, in combination with an amount of a statin which is effective to treat, prevent, or ameliorate the neoplasia. Related methods for treating, preventing or ameliorating breast cancer, or liver cell neoplasia are also provided. In addition, methods for modulating a cholesterol biosynthesis pathway and a stress response pathway in a subject are provided. These methods include administering to a subject a composition comprising an anti-neoplastic synergistic amount of a statin and actein. Compositions for carrying out such methods are also provided.

US Patent:

20120208776, Aug 16, 2012

Filed:

Apr 5, 2012

Appl. No.:

13/440655

Inventors:

Linda Saxe Einbond - Crestwood NY, US
Morando Soffritti - Bologna, IT
Kyle Louis Kolaja - San Mateo CA, US
Richard John Brennan - San Jose CA, US
I. Bernard Weinstein - New York NY, US
Joan Weinstein - New York NY, US
Tamara Weinstein - Decatur GA, US
Claudia Weinstein - New York City NY, US
Matthew Weinstein - Brooklyn NY, US

International Classification:

A61K 31/7048
C12N 9/99
A61P 35/00

US Classification:

514 26, 435184

Abstract:

A method is provided for treating, preventing or ameliorating neoplasia in a subject. This method includes administering to the subject an amount of actein or an amount of an extract of black cohosh that contains a triterpene glycoside, which amount of the actein or black cohosh is effective to treat, prevent or ameliorate the neoplasia, in combination with an amount of a statin which is effective to treat, prevent, or ameliorate the neoplasia. Related methods for treating, preventing or ameliorating breast cancer, or liver cell neoplasia are also provided. In addition, methods for modulating a cholesterol biosynthesis pathway and a stress response pathway in a subject are provided. These methods include administering to a subject a composition comprising an anti-neoplastic synergistic amount of a statin and actein. Compositions for carrying out such methods are also provided.

US Patent:

20120219643, Aug 30, 2012

Filed:

Apr 5, 2012

Appl. No.:

13/440496

Inventors:

Linda Saxe Einbond - Crestwood NY, US
Morando Soffritti - Bologna, IT
I. Bernard Weinstein - New York NY, US
Joan Weinstein - New York NY, US
Tamara Weinstein - Decatur GA, US
Claudia Weinstein - New York NY, US
Matthew Weinstein - Brooklyn NY, US

International Classification:

A61K 36/71
C12N 5/09
C12N 5/071
A61P 35/00
A61K 31/7048

US Classification:

424725, 514 26, 435375

Abstract:

A method for treating, preventing or ameliorating breast cancer is provided by administering a synergistic amount of digitoxin and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be paclitaxel. Methods for treating or preventing a neoplasia using a synergistic combination, and compositions of a synergistic combination of a cardiac glycoside and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be a taxane are also provided. The compositions may also be used in a method for modulating NaKATPase activity. In addition, a method for inhibiting the progression or development of breast cancer in vivo by administering either actein or an extract of black cohosh comprising triterpene glycosides and optionally at least one other chemoprotective agent is provided.

US Patent:

20090186837, Jul 23, 2009

Filed:

Aug 13, 2008

Appl. No.:

12/228562

Inventors:

Linda Saxe Einbond - Crestwood NY, US
Morando Soffritti - S. Lazzaro Di Savena, IT
I. Bernard Weinstein - New York NY, US
Joan Weinstein - New York NY, US

International Classification:

A61K 31/7048
A61P 35/00

US Classification:

514 26

Abstract:

A method for treating, preventing or ameliorating breast cancer is provided by administering a synergistic amount of digitoxin and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be paclitaxel. Methods for treating or preventing a neoplasia using a synergistic combination, and compositions of a synergistic combination of a cardiac glycoside and either actein or an extract of black cohosh comprising triterpene glycosides, and optionally another chemopreventive agent which may be a taxane are also provided. The compositions may also be used in a method for modulating NaKATPase activity. In addition, a method for inhibiting the progression or development of breast cancer in vivo by administering either actein or an extract of black cohosh comprising triterpene glycosides and optionally at least one other chemoprotective agent is provided.