Joel L Kaar

US Patent:

8323379, Dec 4, 2012

Filed:

Oct 24, 2011

Appl. No.:

13/280033

Inventors:

William J. Federspiel - Pittsburgh PA, US
Alan J. Russell - Gibsonia PA, US
Joel Kaar - Bryn Mawr PA, US

Assignee:

University of Pittsburgh—of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

B01D 53/22
C12N 11/00
C12N 11/08

US Classification:

95 46, 95 45, 95 51, 95 54, 96 6, 96 8, 96 10, 96 11, 96 12, 210640, 21050021, 21050027, 210506, 604 501, 604 614, 427535, 427569, 435174, 435180

Abstract:

A method of improving the blood compatibility of a blood-contacting surface includes immobilizing carbonic anhydrase on the surface, wherein the surface exhibits carbonic anhydrase activity of at least 20% of maximum theoretical activity of the surface based on monolayer surface coverage of carbonic anhydrase.

US Patent:

8043411, Oct 25, 2011

Filed:

Jun 16, 2010

Appl. No.:

12/816455

Inventors:

William J. Federspiel - Pittsburgh PA, US
Allan J. Russell - Gibsonia PA, US
Joel Kaar - Bryn Mawr PA, US

Assignee:

University of Pittsburgh - of the Commonwealth System of Higher Education - Pittsburgh PA

International Classification:

B01D 53/22

US Classification:

95 46, 95 45, 95 51, 95 54, 96 6, 96 8, 96 10, 96 11, 96 12, 210640, 21050021, 21050027, 210506, 604 501, 604 614, 427535, 427569

Abstract:

A device for removal of at least a portion of carbon dioxide from an aqueous fluid includes at least one membrane through which carbon dioxide can pass to be removed from the fluid and immobilized carbonic anhydrase on or in the vicinity of a first surface of the membrane to be contacted with the fluid such that the immobilized carbonic anhydrase comes into contact with the fluid. The first surface exhibits carbonic anhydrase activity of at least 20% of maximum theoretical activity of the first surface of the membrane based on monolayer surface coverage of carbonic anhydrase in the case that the carbonic anhydrase is immobilize on the first surface.

US Patent:

20080014622, Jan 17, 2008

Filed:

Jun 8, 2007

Appl. No.:

11/811265

Inventors:

William Federspiel - Pittsburgh PA, US
Alan Russell - Gibsonia PA, US
Joel Kaar - Bryn Mawr PA, US

International Classification:

C12N 11/04
C12M 3/00

US Classification:

435182000, 435289100

Abstract:

A device for removal of at least a portion of carbon dioxide from an aqueous fluid includes at least one membrane through which carbon dioxide can pass to be removed from the fluid and immobilized carbonic anhydrase on or in the vicinity of a first surface of the membrane to be contacted with the fluid such that the immobilized carbonic anhydrase comes into contact with the fluid. The first surface exhibits carbonic anhydrase activity of at least 20% of maximum theoretical activity of the first surface of the membrane based on monolayer surface coverage of carbonic anhydrase in the case that the carbonic anhydrase is immobilize on the first surface.