John Archdeacon

US Patent:

6962906, Nov 8, 2005

Filed:

Feb 9, 2002

Appl. No.:

10/072975

Inventors:

Vladimir Efimov - Moscow, RU
Joseph Fernandez - Carlsbad CA, US
Dorothy Archdeacon - Carlsbad CA, US
John Archdeacon - Carlsbad CA, US
Oksana Chakhmakhcheva - Moscow, RU
Alla Buryakova - Moscow, RU
Mikhail Choob - Carlsbad CA, US
Kyle Hondorp - Carlsbad CA, US

Assignee:

Active Motif - Carlsbad CA

International Classification:

A01N043/04
A01N061/00
C07H021/00
C12Q001/68

US Classification:

514 44, 514 1, 536 231, 536 243, 435 6

Abstract:

The present invention relates generally to oligonucleotide analogues that include novel protein nucleic acid molecules (PNAs), particularly monomers, dimers, oligomers thereof and methods of making and using these oligonucleotide analogues. The PNAs of the present invention are characterized as including a variety of classes of molecules, such as, for example, hydroxyproline peptide nucleic acids (HypNA), and serine peptide nucleic acids (SerNA). The invention includes monomers, homodimers, heterodimers, homopolymers and heteropolymers of these and other oligonucleotide analogues. The present invention includes methods of using these oligonucleotide analogues in the detection and separating of nucleic acid molecules, including uses that include the utilization of oligonucleotide analogues on a solid support. The present invention also includes methods for purifying or separating nucleic acids, such as mRNA molecules, by hybridization with the oligonucleotides of the present invention. The present invention also includes the use of oligonucleotides of the present invention in antisense and homologous recombination constructs and methods.

US Patent:

7115738, Oct 3, 2006

Filed:

Mar 13, 2001

Appl. No.:

09/805296

Inventors:

Vladimir Efimov - Moscow, RU
Joseph Fernandez - Carlsbad CA, US
Dorothy Archdeacon - Carlsbad CA, US
John Archdeacon - Carlsbad CA, US
Oksana Chakhmakhcheva - Moscow, RU
Alla Buryakova - Moscow, RU
Mikhail Choob - Carlsbad CA, US
Kyle Hondorp - Carlsbad CA, US

Assignee:

Active Motif - Carlsbad CA

International Classification:

C07F 9/40

US Classification:

544243, 544244, 548413

Abstract:

Compounds are described and claimed comprising general formula:.

US Patent:

20030119725, Jun 26, 2003

Filed:

Jul 26, 2001

Appl. No.:

09/915914

Inventors:

Gilles Divita - Paris, FR
May Morris - Paris, FR
Jean Mery - Paris, FR
Frederic Heitz - Paris, FR
Joseph Fernandez - Carlsbad CA, US
John Archdeacon - Carlsbad CA, US
Kyle Hondorp - Carlsbad CA, US

International Classification:

A61K048/00
C07K014/00

US Classification:

514/008000, 514/012000, 514/044000, 530/350000

Abstract:

Peptides that are useful as transfection agents are described. The peptides can facilitate the efficient cellular internalization of a broad range and size of compounds that when non-covalently complexed therewith are efficiently internalized into a cell. Advantages include but are not limited to excellent transfection efficiency, relatively low toxicity, internalization by a broad host cell spectrum, and the simplicity and cost-effectiveness that arise from not having to covalently complex the peptide with a specific molecule to be delivered. Applications include but are not limited to the delivery of diagnostics and therapeutics, as well as drug discovery, gene discovery, and the analysis and/or manipulation of other cellular and molecular biological functions. claims are made for transfection agents, compositions of matter, including pharmaceutical compositions, reagent kits, methods of delivery, and methods of identification of additional peptides for performing and/or including in the same.

US Patent:

20040014644, Jan 22, 2004

Filed:

Feb 7, 2003

Appl. No.:

10/360275

Inventors:

Vladimir Efimov - Moscow, RU
Joseph Fernandez - Carlsbad CA, US
Dorothy Archdeacon - Carlsbad CA, US
John Archdeacon - Carlsbad CA, US
Mikhail Choob - Carlsbad CA, US

International Classification:

A61K048/00

US Classification:

514/008000, 514/044000

Abstract:

The present invention relates generally to oligonucleotide analogues that include novel protein nucleic acid molecules (PNAs), particularly monomers, dimers, oligomers thereof and methods of making and using these oligonucleotide analogues. The PNAs of the present invention are characterized as including a variety of classes of molecules, such as, for example, hydroxyproline peptide nucleic acids (HypNA), and serine peptide nucleic acids (SerNA). The present invention also includes the use of oligonucleotides of the present invention in antisense and homologous recombination constructs and methods.

US Patent:

20180231530, Aug 16, 2018

Filed:

Sep 2, 2016

Appl. No.:

15/751143

Inventors:

- Franklin Lakes NJ, US
Eric Jensen - San Diego CA, US
John Archdeacon - Carlsbad CA, US
Brent S. Gaylord - San Diego CA, US

International Classification:

G01N 33/532
G06F 17/30
G06F 19/00
G06F 7/10
G06Q 90/00

Abstract:

Aspects of the present disclosure include systems for use in preparing a labelled biomolecule reagent. Systems according to certain embodiments include an input manager for receiving a request for a labelled biomolecule reagent, a memory for storing a dataset having a plurality of labelled biomolecule reagent storage identifiers, a processing module communicatively coupled to the memory and configured to identify one or more labelled biomolecule reagent storage identifiers from the dataset that corresponds to the labelled biomolecule reagent request and an output manager for providing the one or more identified labelled biomolecule reagent storage identifiers. A reagent preparatory apparatus for preparing the labelled biomolecule reagent from an activated biomolecule and activated label is also described. Methods for communicating and receiving a labelled biomolecule reagent request and preparing the subject labelled biomolecule reagents are also provided.