John L Caldwell

US Patent:

6561965, May 13, 2003

Filed:

Oct 20, 2000

Appl. No.:

09/693577

Inventors:

Nicholas Corner-Walker - Oesterbro, DK
John W. Caldwell - Glenside PA

Assignee:

Alfa Laval Inc. - Glen Allen VA

International Classification:

B04B 120

US Classification:

494 53

Abstract:

The present invention is directed to a mist pump for a conveyor of a decanter centrifuge. The mist pump is incorporated into the feed chamber and prevents mist from leaving the feed zone and building up a layer of feed in the conveyor hub. The mist pump includes a plurality of vanes attached to, extending radially inward from and spaced about an interior surface of the sidewall of the feed chamber. The mist pump also includes a ring positioned coaxially about the longitudinal axis, attached to each of the pump vanes and spaced radially inward from the sidewall to provide a plurality of return openings defined by the ring and the sidewall.

US Patent:

6572524, Jun 3, 2003

Filed:

Jul 14, 2000

Appl. No.:

09/616443

Inventors:

John W. Caldwell - Glenside PA

Assignee:

Alfa Laval Inc. - Warminster PA

International Classification:

B04B 120

US Classification:

494 53

Abstract:

A decanter centrifuge is defined for separating a heavy phase material from a liquid within a feed mixture. The decanter centrifuge includes a bowl rotatable about its longitudinal axis for separation of the heavy phase material from the liquid feed mixture due to centrifugal force. The bowl typically includes a cylindrical portion and a frusto-conical portion at one end. A solids discharge is provided in the restricted end of the frusto-conical bowl portion. A screw conveyor is coaxially mounted for rotation within the bowl, having a spiraled conveyor flight extending radially outwardly to a position adjacent the inside wall of the bowl. The conveyor is adapted to rotate at a relative speed with respect to the bowl for conveying separated heavy phase material toward the heavy phase discharge. A baffle in the form of a disc extends radially outwardly from the conveyor hub and is adapted to project into the separated heavy phase material being conveyed along the bowl wall. A shelf is positioned between the disc and a forward or conveying portion of the conveyor flight.

US Patent:

6589154, Jul 8, 2003

Filed:

May 30, 2001

Appl. No.:

09/867715

Inventors:

John W. Caldwell - Glenside PA

Assignee:

Alfa Laval Inc. - Glen Allen VA

International Classification:

B04B 120

US Classification:

494 53, 494 84

Abstract:

A decanter centrifuge is disclosed for separating a liquid feed mixture into constituent parts. The decanter centrifuge includes a bowl assembly mounted for rotation about a longitudinal axis. Opposite ends of the bowl assembly are rotatably supported by first and second bearings. A motor is engaged with one end of the bowl assembly for rotating the bowl about the longitudinal axis. A screw conveyor is coaxially mounted within the bowl with a conveyor shaft attached thereto. A gear box is located between the second bearing and the bowl and includes a transmission engaged to the shaft. The transmission rotates the conveyor at a relative speed with respect to the bowl. A plurality of circumferentially spaced posts mount the gear box to the bowl, spacing the gear box apart from the bowl. Effluent discharge ports on the bowl discharge effluent into the space between the bowl and the gear box.

US Patent:

7041666, May 9, 2006

Filed:

Nov 26, 2002

Appl. No.:

10/304504

Inventors:

Julius J. Matasi - Monmouth Junction NJ, US
John P. Caldwell - Ringwood NJ, US
Deen Tulshian - Lebanon NJ, US
Lisa S. Silverman - Edison NJ, US
Bernard R. Neustadt - West Orange NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D 487/04
A61K 31/519
A61P 25/18
A61P 25/16
A61P 25/28

US Classification:

5142342, 544263, 544118, 544244, 5142621, 514 81

Abstract:

Disclosed are compounds having the structural formula or pharmaceutically acceptable salts or solvates thereof, wherein.

US Patent:

7592348, Sep 22, 2009

Filed:

Dec 13, 2004

Appl. No.:

11/010772

Inventors:

Zhaoning Zhu - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan C. Ye - Edison NJ, US
Johannes H. Voigt - Cranford NJ, US
Corey Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham Township NJ, US
William J. Greenlee - Teaneck NJ, US
Robert Mazzola - Stewartsville NJ, US
John Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Tao Guo - Dayton NJ, US
Thuy X. H. Le - Monmouth Junction NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Rachael C. Hunter - Princeton NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/505
C07D 239/02

US Classification:

514272, 544321

Abstract:

Disclosed are compounds of the formula IAlso disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic antagonist.

US Patent:

7700603, Apr 20, 2010

Filed:

Jun 9, 2005

Appl. No.:

11/149027

Inventors:

Zhaoning Zhu - Plainsboro NJ, US
Brian A McKittrick - New Vernon NJ, US
Yuanzan C Ye - Edison NJ, US
Johannes H Voigt - Cranford NJ, US
Corey Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham Township NJ, US
William J. Greenlee - Teaneck NJ, US
Robert Mazzola - Stewartsville NJ, US
John Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Tao Guo - Dayton NJ, US
Thuy X. H. Le - Monmouth Junction NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Rachael C. Hunter - Princeton NJ, US
Michelle L. Morris - Lawrenceville NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - East Windsor NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A01N 43/54
C07D 239/02
C07D 239/42
C07D 401/04

US Classification:

514256, 544320, 544321

Abstract:

Disclosed are compounds of the formula IAlso disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.

US Patent:

7763609, Jul 27, 2010

Filed:

Feb 23, 2007

Appl. No.:

11/710582

Inventors:

Zhaoning Zhu - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan C. Ye - Edison NJ, US
Johannes H. Voigt - Cranford NJ, US
Corey O. Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham Township NJ, US
William J. Greenlee - Teaneck NJ, US
Robert D. Mazzola - Stewartsville NJ, US
John P. Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Xiaoxiang Liu - River Vale NJ, US
Tao Guo - Dayton NJ, US
Thuy X. E. Le - Monmouth Junction NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Plainsboro NJ, US
Rachael C. Hunter - Princeton NJ, US
Michelle L. Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - East Windsor NJ, US
Ying Huang - East Brunswick NJ, US
Guoqing Li - Belle Mead NJ, US
Jianping Pan - Monmouth Junction NJ, US
Jeffrey A. Misiaszek - Kenilworth NJ, US
Gaifa Lai - Monmouth Junction NJ, US
Jingqi Duo - Monmouth Junction NJ, US
Chuanxing Qu - Scotch Plains NJ, US
Yuefei Shao - Princeton NJ, US

Assignee:

Schering Corporation - Kenilworth NJ
Pharmacopeia, LLC - San Diego CA

International Classification:

A61K 31/535
C07D 273/04

US Classification:

5142292, 544 66

Abstract:

Disclosed are compounds of the formula IAlso disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.

US Patent:

7973067, Jul 5, 2011

Filed:

Dec 10, 2008

Appl. No.:

12/331787

Inventors:

Zhaoning Zhu - Plainsboro NJ, US
Brian McKittrick - New Vernon NJ, US
Yuanzan C. Ye - North Brunswick NJ, US
Johannes H. Voigt - Cranford NJ, US
Corey Strickland - Martinsville NJ, US
Elizabeth M. Smith - Verona NJ, US
Andrew Stamford - Chatham Township NJ, US
William J. Greenlee - Teaneck NJ, US
John P. Caldwell - Ringwood NJ, US
Jared N. Cumming - Garwood NJ, US
Lingyan Wang - East Brunswick NJ, US
Yusheng Wu - New York NY, US
Ulrich Iserloh - Hoboken NJ, US
Tao Guo - Dayton NJ, US
Thuy X. H. Le - Monmouth Junction NJ, US
Kurt W. Saionz - Cranford NJ, US
Suresh D. Babu - Pennington NJ, US
Rachel C. Hunter - Wayne PA, US
Michelle L. Morris - Lawrenceville NJ, US
Huizhong Gu - Monmouth Junction NJ, US
Gang Qian - Kendall Park NJ, US
Dawit Tadesse - Avenel NJ, US

Assignee:

Schering Corporation - Rahway NJ

International Classification:

A01N 43/50
A61K 31/415
C07D 233/00

US Classification:

514389, 514391, 5483215

Abstract:

Disclosed are compounds of the formula IAlso disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic magonist or mantagonist.