John Lewis Carson

US Patent:

6708141, Mar 16, 2004

Filed:

Sep 28, 1999

Appl. No.:

09/407383

Inventors:

James C. Schaff - Cheshire CT
John Carson - West Hartford CT
Leslie Loew - West Hartford CT

Assignee:

The University of Connecticut - Storrs CT

International Classification:

G06G 760

US Classification:

703 2, 703 11, 702 19

Abstract:

A method and apparatus for modeling cellular structure is disclosed. The system incorporates a theoretical hypotheses of cellular physiology into a simulation framework that allows direct comparison of simulation results with experimental data. The description of the biological model is kept independent of the solution by the use of an integrated anatomical and physiological modeling language. This framework allows complex heterogeneous intracellular chemical simulations to be built with little or no knowledge of the underlying numerical methods. Because the simulation results are easily compared to the experimental results, the user can more easily confirm the hypothesis.

US Patent:

62250825, May 1, 2001

Filed:

May 9, 1997

Appl. No.:

8/853980

Inventors:

John Carson - West Hartford CT
Sunjong Kwon - Newington CT
Kevin Ainger - Zurich, CH
Daniela Avossa - Zurich, CH

Assignee:

Research Corporation Technologies, Inc. - Tucson AZ

International Classification:

C12N 1567
C12N 1511
C12N 1563
C12N 510

US Classification:

435 691

Abstract:

The present invention provides isolated nucleic acid molecules which comprise sequences from the 3' UTR of myelin basic protein (MBP) mRNA. The subject isolated nucleic acid molecules confer properties such as localization, transport and increased translational efficiency of a heterologous mRNA transcript when transcribed into such mRNA. The present invention also provides vectors comprising the subject isolated nucleic acids. The vectors are useful for increasing translational efficiency of mRNA transcripts produced by a heterologous gene incorporated therein. Also provided by the present invention are methods for increasing translation of a heterologous gene. The methods comprise transforming a eukaryotic cell with at least one of the subject vectors having coding sequence for a heterologous gene. Methods for enhancing gene therapy are also provided.

US Patent:

62194402, Apr 17, 2001

Filed:

Jan 16, 1998

Appl. No.:

9/008649

Inventors:

James C. Schaff - Cheshire CT
John Carson - West Hartford CT
Leslie Loew - West Hartford CT

Assignee:

The University of Connecticut - Storrs CT

International Classification:

G06K 900

US Classification:

382128

Abstract:

A method of simulating a biological material.

Address:

4608 Oakden Ln, Memphis, TN 38125

VIN:

2G1WB58K279171025

Make:

CHEVROLET

Model:

IMPALA

Year:

2007