John A Coller

US Patent:

20060238855, Oct 26, 2006

Filed:

Jan 6, 2006

Appl. No.:

11/327287

Inventors:

John Coller - Redwood City CA, US
Michael Fero - Portola Valley CA, US
Ian Hsu - 61-1 East Yun, TW
Ching-Lung Huang - Tainan, TW

International Classification:

H01S 3/00

US Classification:

359341100

Abstract:

The present invention provides a method and device for optically extracting discrete features of an object. With this method and device, small regions of interest or features within a relatively large object are optically extracted and collated into a single, condensed image. The condensed image contains all of the features in the original object, but not the parts of the object that are between the features. Thus, the optically extracted features can be viewed at high resolution, but in a limited field of view. Examples of objects that may be optically extracted according to the invention include spots of biomaterial on a biochip, material in wells of a microtiter plate, etc. In addition, this device and method can be used for non-planar objects. In this case, the device and method allow simultaneous visualization of spatially separated features on a surface of a 3-dimensional object.

US Patent:

55335152, Jul 9, 1996

Filed:

Aug 11, 1994

Appl. No.:

8/289083

Inventors:

John A. Coller - Weston MA
Bruce Nappi - Newton MA
Alan J. Lane - Waltham MA

Assignee:

Foster-Miller - Waltham MA
Lahey Clinic Medical Center - Burlington MA

International Classification:

A61B 500

US Classification:

128748

Abstract:

A system for providing real-time measurements of constriction pressure applied by the inner surface of a body lumen, such as a sphincter, includes a probe comprising an elongated core member having a matrix of pressure transducer regions distributed over the surface of the elongated core member. The preferred matrix of pressure transducer regions is addressed by a first inner array of substantially parallel electrically conductive strips substantially conformed circumferentially to at least a portion of the elongated core member, the first array being disposed in overlapping relationship with a second outer array of substantially parallel electrically conductive strips, and substantially conformed axially to at least the same portion of the elongated core member, so as to provide a matrix of intersection regions. Each pressure transducer region is disposed at a corresponding intersection region, and is in electrical contact with both a electrically conductive strip of the first array, and a electrically conductive strip of the second array. In the preferred embodiment the strips of the outer array are mechanically decoupled from one another by axially-directed slits to allow each individual strip to respond independently under hydrostatically applied pressures.

US Patent:

20210324374, Oct 21, 2021

Filed:

Jun 4, 2019

Appl. No.:

15/734512

Inventors:

- San Francisco CA, US
- Stanford CA, US
Peter Mage - Stanford CA, US
John Coller - Stanford CA, US
Hyongsok Tom Soh - San Francisco CA, US

International Classification:

C12N 15/10

Abstract:

The disclosure is directed to methods and compositions for screening a library of aptamers for aptamers having a binding affinity to a target molecule. The methods and compositions described herein utilize a throughput approach that is able to simultaneously measure binding affinity and link the binding affinity to the identity (e.g., sequence) of the aptamer.